Center for Global Infectious Disease Research

The Center for Global Infectious Disease Research translates basic biology into new ways to diagnose, treat and prevent infectious diseases that impact children and adults worldwide. Learn more about the CGIDR.

Meet Us

Our Vision

We will use scientific discovery to understand, treat, prevent and cure infectious disease, developing solutions that help children grow into healthy adults.

Accelerating Progress Toward Cures

  • Working to Prevent Pediatric HIV

    Dr. Lisa Frenkel is developing affordable ways to prevent HIV, and studying key issues such as mother-to-child HIV transmission.

  • Monitoring Bacteria Outbreaks

    Dr. Scott Weissman studies how antibiotic-resistant bacteria emerge, and develops innovative ways to identify and monitor them.

Key Partnerships

Collaborations and partnerships are integral to the CGIDR’s approach. Our investigators work closely with colleagues at the University of Washington, Fred Hutchinson Cancer Research Center and other institutions.


Developing groundbreaking treatments takes more than just the right ideas. It also takes the right people – and the CGIDR is recruiting new members.

  • If you are looking for a job opportunity, please visit our careers page.
  • If you would like information about potential opportunities, or if you would like to volunteer in our research center, please email us.


Gervassi A, Lejarcegui N, Dross S, Jacobson A, Itaya G, Kidzeru E, Gantt S, Jaspan H, Horton H. Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses. PLoS One 2014;9 (9):e107816. PMID25248150. PMCID: PMC4172591.

Tchakoute CT, Hesseling AC, Kidzeru EB, Gamieldien H, Passmore JA, Jones CE, Gray CM, Sodora DL, Jaspan HB. Delaying BCG vaccination until 8 weeks of age results in robust BCG-specific T-cell responses in HIV-exposed infants. J Infect Dis 2015;211 (3):338-346. PMID25108027. PMCID: PMC4318913.

Gendrin C, Lembo A, Whidbey C, Burnside K, Berry J, Ngo L, Banerjee A, Xue L, Arrington J, Doran KS, Tao WA, Rajagopal L. The Sensor Histidine Kinase RgfC Affects Group B Streptococcal Virulence Factor Expression Independent of Its Response Regulator RgfA. Infect Immun 2015;83 (3):1078-1088. PMID25561709. PMCID: PMC4333453.

Gantt S, Gachelet E, Carlsson J, Barcy S, Casper C, Lagunoff M. Nelfinavir impairs glycosylation of herpes simplex virus 1 envelope proteins and blocks virus maturation. Adv Virol 2015;2015:687162. PMID25709648. PMCID: PMC4325974.

Stockinger DE, Fong DL, Vogel KW, Durning WM, Torrence AE, Rose TM, Staheli JP, Baldessari A, Murnane RD, Hukkannen RR (2014). Oral squamous cell carcinoma in a pigtailed macaque (Macaca nemestrina). Comp Med 64:234-239. PMID:24956217. PMCID: PMC4067589.

Wagner TA, McKernan JL, Tobin NH, Tapia KA, Mullins JI, Frenkel LM. An increasing proportion of monotypic HIV-1 DNA sequences during antiretroviral treatment suggests proliferation of HIV-infected cells. J Virol 2013; 87 (3):1770-1778. PMID: 23175380. PMCID: PMC3554159.

Wagner TA, McLaughlin S, Garg K, Cheung CYK, Larsen BB, Styrchak S, Huang HC, Edlefsen PT, Mullins JI, Frenkel LM. 2014. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science; 2014; 345 (6196):570-3. PMID: 25011556. PMCID: PMC4230336.

Deslouches B, Steckbeck JD, Craigo JK, Doi Y, Burns JL, Montelaro RC. Engineered Cationic Antimicrobial Peptides (eCAPs) to Overcome Multidrug Resistance by ESKAPE Pathogens. Antimicrob Agents Chemother 59 (2):1329-1333, 2015. PMID25421473. PMCID: PMC4335883.

Vanderhoeven JP, Bierle CJ, Kapur RP, McAdams RM, Beyer RP, Bammler TK, Farin FM, Bansal A, Spencer M, Deng M, Gravett MG, Rubens CE, Rajagopal L, Adams Waldorf KM. Group B streptococcal infection of the choriodecidua induces dysfunction of the cytokeratin network in amniotic epithelium: a pathway to membrane weakening. PLoS Pathog 2014;10 (3):e1003920. PMID24603861. PMCID: PMC3946355.

Bull ME, Heath LM, McKernan-Mullin JL, Kraft KM, Acevedo L, Hitti JE, Cohn SE, Tapia KA, Holte SE, Dragavon JA, Coombs RW, Mullins JI, Frenkel LM. Human immunodeficiency viruses appear compartmentalized to the female genital tract in cross-sectional analyses but genital lineages do not persist over time. J Infect Dis 2013;207 (8):1206-1215. PMID23315326. PMCID: PMC3603533.

Winer RL, Huang CE, Cherne S, Stern JE, Butsch Kovacic MS, Mehta PA, Sauter SL, Galloway DA, Katzenellenbogen RA. Detection of human papillomavirus in the oral cavities of persons with Fanconi anemia. Oral Dis 2015;21 (3):349-354. PMID25158861. PMCID: PMC4344428.

Kronman MP, Zerr DM, Qin X, Englund J, Cornell C, Sanders JE, Myers J, Rayar J, Berry JE, Adler AL, Weissman SJ. Intestinal decontamination of multidrug-resistant Klebsiella pneumoniae after recurrent infections in an immunocompromised host. Diagn Microbiol Infect Dis 2014;80 (1):87-89. PMID25041704. PMCID: PMC4162817.

Garrigues HJ, DeMaster LK, Rubinchikova YE, Rose TM. KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate. Virol 2014;464-465C:118-133. PMID25063885. PMCID: PMC4157101.

Wagner TA, McLaughlin S, Garg K, Cheung CY, Larsen BB, Styrchak S, Huang HC, Edlefsen PT, Mullins JI, Frenkel LM. HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science 2014;345 (6196):570-573. PMID25011556. PMCID: PMC4230336.

Cambier CJ, Takaki KK, Larson RP, Hernandez RE, Tobin DM, Urdahl KB, Cosma CL and Ramakrishnan L. Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids. Nature 2014;505 (7482):218-222. PMID24336213. PMCID: PMC3961847.

Latest News

  • Research on Common Bacteria Could Prevent Stillbirths, Premature Births
    03.10.15 – Seattle Children's on the Pulse
    A study led by Seattle Children’s Research Institute and published today in EMBO Molecular Medicine, titled “A Streptococcal Lipid Toxin Induces Membrane Permeabilization and Pyroptosis Leading to Fetal Injury,” reveals new information on the common bacteria Group B Streptococcus (GBS). Researchers hope these discoveries could one day be used to prevent premature births and stillbirths.
  • New Study Helps Scientists Better Understand Why HIV Causes Lifelong Infection
    07.15.14 – Press Release
    HIV, the virus that causes AIDS, has the ability to integrate into the human genome, making it extremely difficult to cure the infection. A new study by scientists at Seattle Children’s Research Institute, the University of Washington and Fred Hutchinson Cancer Research Center found that when HIV integrates into genes involved with cancer, these cells tend to reproduce to a greater extent than other HIV-infected cells. According to study co-lead Dr. Thor Wagner, “This research brings us closer to understanding why HIV is such a long-lasting infection and may lead us to new avenues to cure HIV.”
  • HPV Research Could Decrease Cancer Risk for Millions
    06.25.14 – Seattle Children's On the Pulse
    The National Cancer Institute has awarded Seattle Children’s Research Institute adolescent medicine expert Dr. Rachel Katzenellenbogen more than $2 million to study what happens in the body between the time of human papillomavirus (HPV) infection and cancer development in search of opportunities to intervene and prevent malignant disease.
  • NIAID Awards $5.3 Million to Seattle Children’s Research Institute and Micronics Inc.
    04.15.14 – Press Release
    Tim Rose, PhD, co-director of the Center for Global Infectious Disease Research, in partnership with Micronics, Inc., has been awarded $5.3 million from the National Institute of Allergy and Infectious Diseases to develop a diagnostic tool and surveillance system that will identify and track influenza viruses.

Participate in Research

Help us answer questions about childhood health and illness, and help other children in the future. Learn more.