Center for Immunity and Immunotherapies


The latest publications from researchers at the Center for Immunity and Immunotherapies include:

  1. Sather BD, Romano Ibarra G, Sommer K, Curinga G, Hale M , Khan I, Singh S, Song Y, Gwiazda KS, Sahni J, Jarjour J, Astrakhan A, Wagner T, Scharenberg AMRawlings DJEfficient Modification of CCR5 in Primary Human Hematopoietic Cells using a megaTAL Nuclease and AAV Donor Template. (2015) Sci Trans Med
  2. Gendrin C, Vornhagen J, Ngo L, Whidbey C, Boldenow E, Santana-Ufret V, Clauson M, Burnside K, Galloway D, Adams Waldorf KM, Piliponsky AM*, Rajagopal L*. Mast cell degranulation by a hemolytic lipid toxin decreases GBS colonization and infection. (2015) Science Advances. 1,e140025 (*co-corresponding authors)
  3. Corrigan-Curay J, O'Reilly M, Kohn DB, Cannon PM, Bao G, Bushman FD, Carroll D, Cathomen T, Joung JK, Roth D, Sadelain M, Scharenberg AM, von Kalle C, Zhang F, Jambou R, Rosenthal E, Hassani M, Singh A, Porteus MH. Genome editing technologies: defining a path to clinic. Mol Ther. 2015 May;23(5):796-806. doi: 10.1038/mt.2015.54. PMID: 25943494
  4. Wang X, Chiang AF, Khan I, Pan D, Rawlings DJMiao CHIntraosseous Delivery of Lentiviral Vectors Targeting Factor VIII Expression in Platelets Corrects Murine Hemophilia A. (2015) Mol Ther. 23(4): 617-26. PMCID: PMC4395783
  5. Olszko ME, Adair JE, Linde I, Rae DT, Trobridge P, Hocum JD, Rawlings DJ, Kiem HP, Trobridge GD. Foamy Viral Vector Integration Sites in SCID-repopulating Cells After MGMTP140K-mediated in Vivo Selection. (2015) Gene Therapy. [Epub ahead of print]. PMID: 25786870
  6. Tampella G, Kerns HM, Niu D, Singh S, Khim S, Bosch KA, Garrett ME, Moguche A, Evans E, Browning B, Jahan TA, Nacht M, Wolf-Yadlin A, Plebani A, Hamerman JA, Rawlings DJJames RGThe Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages. (2015) J Immunol. [Epub ahead of print]. PMID: 26026062
  7. Treosulfan-Based Conditioning and Hematopoietic Cell Transplantation for Nonmalignant Diseases: A Prospective Multi-Center Trial. Burroughs LM, Nemecek ER, Torgerson TR, Storer BE, Talano JA, Domm J, Giller RH, Shimamura A, Delaney C, Skoda-Smith S, Thakar MS, Baker KS, Rawlings DJ, Englund JA, Flowers ME, Deeg HJ, Storb R, Woolfrey AE. Biol Blood Marrow Transplant. 2014 Sep 4. pii: S1083-8791(14)00536-9. doi: 10.1016/j.bbmt.2014.08.020
  8. CD4+ T Cells and CD40 Participate in Selection and Homeostasis of Peripheral B Cells. Schwartz MA, Kolhatkar NS, Thouvenel C, Khim S, Rawlings DJ. J Immunol. 2014 Aug 29. pii: 1400798.
  9. DOCK8 regulates protective immunity by controlling the function and survival of RORγt+ ILCsAkhilesh K. Singh,Ahmet Eken, Mallory Fry, Estelle Bettelli & Mohamed Oukka. Nature Communications, Article number: 4603 doi:10.1038/ncomms5603 Received 06 May 2014 Accepted 07 July 2014 Published 05 August 2014
  10. IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt. Li H, Hsu HC, Wu Q, Yang P, Li J, Luo B, Oukka M, Steele CH 3rd, Cua DJ, Grizzle WE, Mountz JD. Nature Communications. 2014 Jul 8;5:4259. doi: 10.1038/ncomms5259. PMID:25001511
  11. Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells. Wang CX, Sather BD, Wang X, Adair J, Khan I, Singh S, Lang S, Adams A, Curinga G, Kiem HP, Miao CH, Rawlings DJ, Torbett BE. Blood. 2014 Jun 9. pii: blood-2013-12-546218. [Epub ahead of print] PMID: 24914132
  12. Asthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix componentsReeves SR, Kolstad T, Lien TY, Elliott M, Ziegler SF, Wight TN, Debley JS. Journal J Allergy Clin Immunol. 2014 May 26. pii: S0091-6749(14)00568-5. doi: 10.1016/j.jaci.2014.04.007. [Epub ahead of print]
  13. Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation. Jackson SW, Scharping NE, Kolhatkar NS, Khim S, Schwartz MA, Li QZ, Hudkins KL, Alpers CE, Liggitt D, Rawlings DJ. Journal of Immunology. 2014 May 15;192(10):4525-32. doi: 10.4049/jimmunol.1400098. Epub 2014 Apr 7. PMID:24711620
  14. IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1. Heinemann C, Heink S, Petermann F, Vasanthakumar A, Rothhammer V, Doorduijn E, Mitsdoerffer M, Sie C, Prazeres da Costa O, Buch T, Hemmer B, Oukka M, Kallies A, Korn T. Nature Communications. 2014 May 6;5:3770. doi: 10.1038/ncomms4770. PMID:24796719
  15. Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33. Lai Y, Altemeier WA, Vandree J, Piliponsky AM, Johnson B, Appel CL, Frevert CW, Hyde DM, Ziegler SF, Smith DE, Henderson WR Jr, Gelb MH, Hallstrand TS. Journal of Allergy and Clinical Immunology. 2014 May;133(5):1448-55. doi: 10.1016/j.jaci.2013.08.052. Epub 2013 Nov 9. PMID:24220317
  16. Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus. Wang Y, Khan IF, Boissel S, Jarjour J, Pangallo J, Thyme S, Baker D, Scharenberg AM, Rawlings DJ. Nucleic Acids Research. 2014;42(10):6463-75. doi: 10.1093/nar/gku224. Epub 2014 Mar 25. PMID: 24682825
  17. Intravenous injection of a foamy virus vector to correct canine SCID-X1. Burtner CR, Beard BC, Kennedy DR, Wohlfahrt ME, Adair JE, Trobridge GD, Scharenberg AM, Torgerson TR, Rawlings DJ, Felsburg PJ, Kiem HP. Blood. 2014 Jun 5;123(23):3578-84. doi: 10.1182/blood-2013-11-538926. Epub 2014 Mar 18. PMID:24642749
  18. Development of therapeutic microbubbles for enhancing ultrasound-mediated gene delivery. Sun RR, Noble ML, Sun SS, Song S, Miao CH. Journal of Controlled Release. 2014 May 28;182:111-20. doi: 10.1016/j.jconrel.2014.03.002. Epub 2014 Mar 18. PMID:24650644
  19. Interleukin 23 in Crohn's disease. Eken A, Singh AK, Oukka M. Inflammatory Bowel Disease. 2014 Mar;20(3):587-95. doi: 10.1097/01.MIB.0000442014.52661.20. PMID:24481050
  20. In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease. Aubert M, Boyle NM, Stone D, Stensland L, Huang ML, Magaret AS, Galetto R, Rawlings DJ, Scharenberg AM, Jerome KR. Molecular Therapy – Nucleic Acids. 2014 Feb 4;3:e146. doi: 10.1038/mtna.2013.75. PMID:24496438 
  21. Simvastatin promotes adult hippocampal neurogenesis by enhancing Wnt/β-catenin signaling. Robin NC, Agoston Z, Biechele TL, James RG, Berndt JD, Moon RT. (2014) Stem Cell Reports 2(1):9-17. PMCID: PMC3916759
  22. Colitogenic effector T cells: roles of gut-homing integrin, gut antigen specificity and γδ T cells. Do JS, Visperas A, Freeman ML, Iwakura Y, Oukka M, Min B. Immunology & Cell Biology. 2014 Jan;92(1):90-8. doi: 10.1038/icb.2013.70. Epub 2013 Nov 5.
  23. Anti-CD20 as the B-Cell Targeting Agent in a Combined Therapy to Modulate Anti-Factor VIII Immune Responses in Hemophilia a Inhibitor Mice. Liu CL, Ye P, Lin J, Butts CL, Miao CH. Frontiers in Immunology. 2014 Jan 6;4:502. doi: 10.3389/fimmu.2013.00502. eCollection 2014 Jan 6. PMID:24432019