Debley Lab

Selected Publications

  1. Debley JS, Barrow KA, Rich LM, Singh P, McKone EF, Nichols DP. Correlation between Ivacaftor-induced CFTR Activation in Airway Epithelial Cells and Improved Lung Function: A Proof-of-Concept.  Ann Am Thorac Soc. 2020 May 18. doi: 10.1513/AnnalsATS.202001-082RL. Online ahead of print. PMID: 32421352
  2. Shubin NJ, Clauson M, Niino K, Kasprzak V, Tsuha A, Guga E, Bhise G, Acharya M, Snyder JM, Debley JS, Ziegler SF, Piliponsky AM.  Thymic stromal lymphopoietin protects in a model of airway damage and inflammation via regulation of caspase-1 activity and apoptosis inhibition.  Mucosal Immunol. 2020. doi: 10.1038/s41385-020-0271-0. PMID: 32103153
  3. Reeves SR, Barrow KA, Rich LM, White MP, Shubin NJ, Chan CK, Kang I, Ziegler SF, Piliponsky AM, Wight TN, Debley JS.  Respiratory Syncytial Virus Infection of Human Lung Fibroblasts Induces a Hyaluronan-Enriched Extracellular Matrix That Binds Mast Cells and Enhances Expression of Mast Cell Proteases.  Front Immunol. 2020 28;10:3159. doi: 10.3389/fimmu.2019.03159. PMID: 32047499
  4. White MP, Kolstad TK, Elliott M, Cochrane ES, Stamey DC, Debley JS.  Exhaled Nitric Oxide in Wheezy Infants Predicts Persistent Atopic Asthma and Exacerbations at School Age.  J Asthma Allergy. 2020 Jan 7;13:11-22. doi: 10.2147/JAA.S227732. PMID: 32021309
  5. Altman MC, Lai Y, Nolin JD, Long S, Chen CC, Piliponsky AM, Altemeier WA, Larmore M, Frevert CW, Mulligan MS, Ziegler SF, Debley JS, Peters MC, Hallstrand TS.  Airway Epithelium-Shifted Mast Cell Infiltration Regulates Asthmatic Inflammation via IL-33 Signaling.  J Clin Invest. 2019 Nov 1;129(11):4979-4991. doi: 10.1172/JCI126402. PMID: 31437129
  6. Reeves SR, Barrow KA, Kolstad TK, White MP, Rich LM, Wight TN, Debley JS. Fibroblast gene expression following asthmatic bronchial epithelial cell conditioning correlates with epithelial donor lung function and exacerbation history. Scientific reports. 2018; 8(1):15768.
  7. Reeves SR, Barrow KA, White MP, Naushab M, Debley JS.  Stability of Gene Expression by Primary Bronchial Epithelial Cells Over Increasing Passage Number. BMC Pulmonary Medicine.  BMC Pulmonary Medicine. 2018; 18(1):91.
  8. Altman MC, Reeves SR, Parker AR, Whalen E, Misura KMS, Barrow KA, James RG, Hallstrand TS, Ziegler SF, Debley JS. Interferon response by bronchial epithelial cells from children with asthma to RSV is inversely correlated with pulmonary function. J Allergy Clin Immunol, 2018;142(2):451-459. PMID: 29106997 PMCID: PMC5951761
  9. James RG, Reeves SR, Barrow KA, White MP, Glukhova VA, Haghighi C, Seyoum D, Debley JS. Deficient Follistatin-like 3 Secretion by Asthmatic Airway Epithelium Impairs Fibroblast Regulation and Fibroblast-to-myofibroblast Transition. Am J Respir Cell Mol Biol. 2018; 59(1):104-113. PMID: 29394092
  10. Reeves SR, Kolstad T, Lien TY, Herrington-Shaner SN, Debley JS. Fibroblast-Myofibroblast Transition is Differentially Regulated by Bronchial Epithelial Cells from Asthmatic Children. Respiratory Research, Respiratory Research, 2015;16(1):21.
  11. Reeves SR, Kolstad T, Lien TY, Elliott M, Ziegler SF, Wight TN, Debley JS. Asthmatic Airway Epithelial Cells Differentially Regulate Fibroblast Expression of Extracellular Marix Components. J Allergy Clin Immunol, 2014; 134(3):663-70.
  12. Lee HC, Headley MB, Loo Y, Berlin A, Gale M, Debley JS, Lukacs NW, Ziegler SF. Thymic Stromal Lymphopoietin is induced by Respiratory Syncytial Virus-infected Airway Epithelial Cells and Promotes a Type 2 Response to Infection.  J Allergy Clin Immunol. 2012 Nov;130(5):1187-1196. PMID: 2981788
  13. Miazgowicz MM, Elliott MS, Debley JS, Ziegler SF. Respiratory Syncytial Virus Induces Functional Thymic Stromal Lymphopoietin Receptor in Airway Epithelial Cells. J Inflamm Res. 2013;6:53-61. PMCID: PMC3617816
  14. Iwanaga K, Elliott MS, Vedal S, Debley JS. Urban Particulate Matter Induces Pro-Remodeling Factors by Airway Epithelial Cells from Healthy and Asthmatic Children. Inhalation Toxicology. 2013;25(12):653-60. PMID:24102466
  15. Lopez-Guisa JM, Powers C, File D, Cochrane E, Jimenez N, Debley JS.  Airway Epithelial Cells from Asthmatic Children Differentially Express Proremodeling Factors.  J Allergy Clin Immunol  2012;129(4):990-7. PMCID: PMC3604976