The Allenspach Lab is focused on translational work to understand immune dysregulation disorders – those with overlapping immunodeficiency and autoimmune features. The lab combines genetic and deep immunophenotyping techniques to identify novel pathogenic variants and use human samples and animal models to probe the mechanism of dysregulation.
The Acharya Lab studies how immune cells integrate signals from pathogens and their environment to produce effective immunity against pathogens while maintaining tolerance to self-derived antigens.
The Debley Lab is engaged in an array of translational work investigating the role of the airway epithelium in childhood asthma.
The Jackson Lab studies the immune mechanisms underlying the development of systemic autoimmune diseases, focusing in particular on the role of B cells in systemic lupus erythematosus (SLE). The lab uses various chimeric and genetic knock-in murine strains to model the biology of human autoimmune diseases.
The James Lab is interested in understanding how genetic variation and pharmacological treatments alter cellular signaling. The lab uses quantitative proteomics to understand which signaling pathways are up-regulated during disease and in response to these therapies.
The Miao Lab pursues safer, more effective treatments for hemophilia. The lab focuses on developing innovative gene therapy and immunotherapy approaches.
The Piliponsky Lab studies inflammatory responses involving mast cells and myeloid cells. Its goal is to understand how the body controls the immune system’s response to bacterial infections – and how this process becomes dysregulated.
The Stevens Lab is working to understand what causes autoimmune diseases, and is pursuing innovative treatments for scleroderma, lupus and juvenile idiopathic arthritis. The lab currently investigates how T cells are regulated, how that process goes awry in patients with autoimmune disease, and how it can be corrected through potential new treatments.
The Torgerson Lab uses a translational approach to understand the molecular and cellular basis of immune dysregulation in humans through the study of congenital immune syndromes characterized by defects in effector and regulatory T cells. The lab develops diagnostic tools, interrogates the molecular and cellular basis of disease, and designs novel therapeutic approaches for these disorders.
The Zheng Lab is dedicated towards understanding the pathways of disease in pediatric gastrointestinal autoimmune conditions such as Crohn’s Disease and Ulcerative Colitis.