Danielle M Zerr, MD, MPH

Danielle M Zerr, MD, MPH

Infectious Disease and Virology, Infectious Disease Research

On staff since July 1999

Children's Title: Division Chief

Academic Title: Professor, Pediatrics

Foundation Title: Children's Hospital Guild Association Endowed Chair in Pediatric Infectious Disease Research

Research Center: Center for Clinical and Translational Research

"The best part of my work is helping patients with serious infections (and their families) understand their infection and the treatment options."

  • Biography

    Danielle M. Zerr, MD, MPH; Professor and Division Chief of Pediatric Infectious Disease and Adjunct Professor of Epidemiology, University of Washington; Affiliate Investigator at the Fred Hutchinson Cancer Center; and the Medical Director of Infection Prevention at Seattle Childrens Hospital.

    Dr. Zerr's research has focused on two main areas:(1) defining the epidemiology of viral pathogens in healthy children and immunocompromised hosts and (2) describing the epidemiology and defining prevention strategies for healthcare-associated infections. Recent work includes studies aimed at defining the epidemiology of human herpesvirus 6 (HHV-6) in hematopoietic stem cell transplant recipients. In addition, Dr. Zerr collaborates with Dr. Weissman and Dr. Qin in investigating the molecular epidemiology of broad-spectrum beta-lactam resistance in pediatric Enterobacteriaceae infections. Dr. Zerr also leads a multicenter trial aimed at reducing healthcare-associated infections in children with cancer.

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  • Awards and Honors

    Award Name Award Description Awarded By Award Date
    SEATTLE TOP DOCTOR - 2022 Seattle Magazine 2022
    Seattle Top Doctor - 2019 Seattle Magazine 2019
    SEATTLE'S TOP DOCTOR - 2018 Seattle Magazine 2018
    SEATTLE'S TOP DOCTOR - 2017 Seattle Magazine 2017
    SEATTLE MAGAZINE TOP DOCTOR - 2015 Seattle Magazine 2015
    SEATTLE'S TOP DOCTOR - 2015 Seattle Met Magazine 2015
    Society of Healthcare Epidemiology of America (SHEA) Pediatric Investigator Award Society of Healthcare Epidemiology of America 2014
    SEATTLE MAGAZINE TOP DOCTOR - 2014 Seattle Magazine 2014
    SEATTLE'S TOP DOCTOR - 2014 Seattle Metropolitan Magazine 2014
    Seattle's Top Doc Seattle Met Magazine 2013
    Richard A. Molteni Award Medical Staff Award for Professionalism and Quality Seatle Children's Hospital 2013
    Seattle Magazine Top Doctor - 2013 Seattle Magazine 2013
    U.S. News Top Doctor U.S. News and World Report 2012

  • Publications

    Manuscripts in Refereed Journals

    • Komaroff AL, Zerr DM, Flamand L
      Summary of the 11th International Conference on Human Herpesviruses-6A, -6B, and -7.
      31456237 Journal of medical virology, 2020 Jan. : 92(1)4-10
    • Fisher BT, Zaoutis T, Dvorak CC, Nieder M, Zerr D, Wingard JR, Callahan C, Villaluna D, Chen L, Dang H, Esbenshade AJ, Alexander S, Wiley JM, Sung L
      Effect of Caspofungin vs Fluconazole Prophylaxis on Invasive Fungal Disease Among Children and Young Adults With Acute Myeloid Leukemia: A Randomized Clinical Trial.
      31688884 JAMA, 2019 Nov 5 : 322(17)1673-1681
    • Weschke DP, Leisenring WM, Lawler RL, Stevens-Ayers T, Huang ML, Jerome KR, Zerr DM, Hansen JA, Boeckh M, Hill JA
      Inflammatory Cytokine Profile in Individuals with Inherited Chromosomally Integrated Human Herpesvirus 6.
      31678540 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2019 Oct 31
    • Hill JA, Vande Vusse LK, Xie H, Chung EL, Yeung CCS, Seo S, Stevens-Ayers T, Fisher CE, Huang ML, Stewart FM, Jerome KR, Zerr DM, Corey L, Leisenring WM, Boeckh M
      Human Herpesvirus 6B and Lower Respiratory Tract Disease After Hematopoietic Cell Transplantation.
      31449472 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019 Oct 10 : 37(29)2670-2681
    • Casto AM, Adler AL, Makhsous N, Crawford K, Qin X, Kuypers JM, Huang ML, Zerr DM, Greninger AL
      Prospective, Real-time Metagenomic Sequencing During Norovirus Outbreak Reveals Discrete Transmission Clusters.
      30576430 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019 Aug 30 : 69(6)941-948 PMCID:PMC6735836
    • Addetia A, Greninger AL, Adler A, Yuan S, Makhsous N, Qin X, Zerr DM
      A Novel, Widespread qacA Allele Results in Reduced Chlorhexidine Susceptibility in Staphylococcus epidermidis.
      30988144 Antimicrobial agents and chemotherapy, 2019 June : 63(6) PMCID:PMC6535555
    • Hill JA, Ikoma M, Zerr DM, Basom RS, Peddu V, Huang ML, Hall Sedlak R, Jerome KR, Boeckh M, Barcy S
      RNA Sequencing of the In Vivo Human Herpesvirus 6B Transcriptome To Identify Targets for Clinical Assays Distinguishing between Latent and Active Infections.
      30429336 Journal of virology, 2019 Feb 1 : 93(3) PMCID:PMC6340040
    • Tchesnokova VL, Rechkina E, Larson L, Ferrier K, Weaver JL, Schroeder DW, She R, Butler-Wu SM, Aguero-Rosenfeld ME, Zerr D, Fang FC, Ralston J, Riddell K, Scholes D, Weissman S, Parker K, Spellberg B, Johnson JR, Sokurenko EV
      Rapid and Extensive Expansion in the United States of a New Multidrug-resistant Escherichia coli Clonal Group, Sequence Type 1193.
      29961843 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019 Jan 7 : 68(2)334-337 PMCID:PMC6321845
    • Zerr DM
      Human Herpesvirus 6B in the Transplant Recipient: When to Worry, When to Act.
      30590622 Journal of the Pediatric Infectious Diseases Society, 2018 Dec 26 : 7(suppl_2)S75-S78
    • Danziger-Isakov L, Englund J, Green M, Posfay-Barbe KM, Zerr DM
      Cytomegalovirus in Pediatric Hematopoietic Stem Cell Transplantation: A Case-Based Panel Discussion of Current Challenges.
      30590625 Journal of the Pediatric Infectious Diseases Society, 2018 Dec 26 : 7(suppl_2)S72-S74
    • Phan TL, Pritchett JC, Leifer C, Zerr DM, Koelle DM, Di Luca D, Lusso P
      HHV-6B infection, T-cell reconstitution, and graft-vs-host disease after hematopoietic stem cell transplantation.
      29795424 Bone marrow transplantation, 2018 Dec. : 53(12)1508-1517
    • Phan TL, Carlin K, Ljungman P, Politikos I, Boussiotis V, Boeckh M, Shaffer ML, Zerr DM
      Human Herpesvirus-6B Reactivation Is a Risk Factor for Grades II to IV Acute Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.
      29684567 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2018 Nov. : 24(11)2324-2336
    • Phan T, Zerr DM, Boussiotis V, Lusso P, Di Luca D
      Considerations on human Herpesvirus 6 reactivation after cord blood transplantation.
      29985546 American journal of hematology, 2018 Sept. : 93(9)E249-E250
    • Greninger AL, Knudsen GM, Roychoudhury P, Hanson DJ, Sedlak RH, Xie H, Guan J, Nguyen T, Peddu V, Boeckh M, Huang ML, Cook L, Depledge DP, Zerr DM, Koelle DM, Gantt S, Yoshikawa T, Caserta M, Hill JA, Jerome KR
      Comparative genomic, transcriptomic, and proteomic reannotation of human herpesvirus 6.
      29554870 BMC genomics, 2018 Mar 20 : 19(1)204 PMCID:PMC5859498
    • Qin X, Zhou C, Zerr DM, Adler A, Addetia A, Yuan S, Greninger AL
      Heterogeneous Antimicrobial Susceptibility Characteristics in Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients.
      29564400 mSphere, 2018 March : 3(2) PMCID:PMC5853491
    • Hill JA, Mayer BT, Xie H, Leisenring WM, Huang ML, Stevens-Ayers T, Milano F, Delaney C, Jerome KR, Zerr DM, Nichols G, Boeckh M, Schiffer JT
      Kinetics of Double-Stranded DNA Viremia After Allogeneic Hematopoietic Cell Transplantation.
      29020348 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018 Jan 18 : 66(3)368-375 PMCID:PMC5850428
    • Miles-Jay A, Weissman SJ, Adler AL, Tchesnokova V, Sokurenko EV, Baseman JG, Zerr DM
      Epidemiology and Antimicrobial Resistance Characteristics of the Sequence Type 131-H30 Subclone Among Extraintestinal Escherichia coli Collected From US Children.
      29020219 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018 Jan 18 : 66(3)411-419 PMCID:PMC5848265
    • Poole NM, Kronman MP, Rutman L, Weissman SJ, Migita RT, Caglar D, Zerr DM
      Improving Antibiotic Prescribing for Children With Urinary Tract Infection in Emergency and Urgent Care Settings.
      29298246 Pediatric emergency care, 2018 Jan 2
    • Zerr DM, Weissman SJ, Zhou C, Kronman MP, Adler AL, Berry JE, Rayar J, Myers J, Haaland WL, Burnham CD, Elward A, Newland J, Selvarangan R, Sullivan KV, Zaoutis T, Qin X
      The Molecular and Clinical Epidemiology of Extended-Spectrum Cephalosporin- and Carbapenem-Resistant Enterobacteriaceae at 4 US Pediatric Hospitals.
      28339623 Journal of the Pediatric Infectious Diseases Society, 2017 Nov 24 : 6(4)366-375 PMCID:PMC5907845
    • Martin LD, Kallile M, Kanmanthreddy S, Zerr DM
      Infection prevention in pediatric anesthesia practice.
      29030929 Paediatric anaesthesia, 2017 Nov. : 27(11)1077-1083
    • Hill JA, Magaret AS, Hall-Sedlak R, Mikhaylova A, Huang ML, Sandmaier BM, Hansen JA, Jerome KR, Zerr DM, Boeckh M
      Outcomes of hematopoietic cell transplantation using donors or recipients with inherited chromosomally integrated HHV-6.
      28596425 Blood, 2017 Aug 24 : 130(8)1062-1069 PMCID:PMC5570681
    • Greninger AL, Waghmare A, Adler A, Qin X, Crowley JL, Englund JA, Kuypers JM, Jerome KR, Zerr DM
      Rule-Out Outbreak: 24-Hour Metagenomic Next-Generation Sequencing for Characterizing Respiratory Virus Source for Infection Prevention.
      28379561 Journal of the Pediatric Infectious Diseases Society, 2017 Jun 1 : 6(2)168-172 PMCID:PMC5907853
    • Das S, Adler AL, Miles-Jay A, Kronman MP, Qin X, Weissman SJ, Burnham CA, Elward A, Newland JG, Selvarangan R, Sullivan KV, Zaoutis T, Zerr DM
      Antibiotic Prophylaxis Is Associated with Subsequent Resistant Infections in Children with an Initial Extended-Spectrum-Cephalosporin-Resistant Enterobacteriaceae Infection.
      28289030 Antimicrobial agents and chemotherapy, 2017 May : 61(5) PMCID:PMC5404513
    • Hill JA, Mayer BT, Xie H, Leisenring WM, Huang ML, Stevens-Ayers T, Milano F, Delaney C, Sorror ML, Sandmaier BM, Nichols G, Zerr DM, Jerome KR, Schiffer JT, Boeckh M
      The cumulative burden of double-stranded DNA virus detection after allogeneic HCT is associated with increased mortality.
      28209721 Blood, 2017 Apr 20 : 129(16)2316-2325 PMCID:PMC5399484
    • Greninger AL, Zerr DM, Qin X, Adler AL, Sampoleo R, Kuypers JM, Englund JA, Jerome KR
      Rapid Metagenomic Next-Generation Sequencing during an Investigation of Hospital-Acquired Human Parainfluenza Virus 3 Infections.
      27795347 Journal of clinical microbiology, 2017 Jan. : 55(1)177-182 PMCID:PMC5228228
    • Jelic M, Adler AL, Miles-Jay A, Weissman SJ, Kronman MP, Zerr DM
      Use of antibiotics reserved for resistant Gram-negative infections at free-standing U.S. children’s hospitals from 2004 to 2014
      27139575 Infect Contr Hosp Epidemiol, 2016 : 37(8)967-970
    • Kronman MP, Oron AP, Ross RK, Hersh AL, Newland JG, Goldin A, Rangel SJ, Weissman SJ, Zerr DM, Gerber JS
      Extended- versus Narrower-Spectrum Antibiotics for Appendicitis
      27354453 Pediatrics, 2016 : 138(1)
    • Bryant KA, Harris AD, Gould CV, Humphreys E, Lundstrom T, Murphy DM, Olmsted R, Oriola S, Zerr D
      Necessary infrastructure of infection prevention and healthcare epidemiology programsA: a review
      2683207 Control Hosp Epidemiol, 2016 : 37(4)371-80
    • Chu HY, Chin J, Pollard J, Zerr DM, Englund JA
      Clinical Outcomes in outpatient respiratory syncytial virus infection in immunocompromised children
      26859306 Influenza and Other Respiratory Viruses, 2016 : 10(3)205-10
    • Kronman MP, Hersh AL, Gerber JS, Ross RK, Newland JG, Goldin A, Rangel SJ, Oron AP, Zerr DM.
      Identifying Antimicrobial Stewardship Targets for Pediatric Surgical Patients
      26407258 J Pediatric Infect Dis Soc, 2016 : 4(4)e100-8
    • Zerr DM, Miles-Jay A, Kronman MP, Zhou C, Adler AL, Haaland W, Weissman SJ, Elward A, Newland J, Selvarangan R, Sullivan KV, Zaoutis T, Qin X
      Previous antibiotic exposure increases risk of infection with extended spectrum beta lactam- and AmpC-producing E. coli and Klebsiella pneumoniae in pediatric patients
      27139486 Antimicrobial Agents and Chemotherapy, 2016 : 60(7)4237-43
    • Sedlak RH, Hill J, Nguyen T, Cho M, Levin G, Cook L, Huang M-L, Flamand L, Zerr DM, Boeckh M, and Jerome K
      Detection of HHV-6B reactivation in hematopoietic cell transplant recipients with inherited chromosomally integrated HHV-6A by droplet digital PCR
      26888901 J Clin Microbiol, 2016 : 54(5)1223-7
    • Hill JA, Hall-Sedlak R, Magaret A, Huang M-L, Zerr DM, Jerome KR, Boeckh M
      Efficient Identification of Inherited Chromosomally Integrated Human Herpesvirus 6 Using Specimen Pooling.
      26921738 J Clin Virol., 2016 : 20(77)71-76
    • Qin X, PhD, Zerr DM, Kronman MP, Adler AL, Berry JE, Rich S, Buccat AM, Xu M, Englund JA
      Comparison of Molecular Detection Methods for Pertussis in Children during a State-wide Outbreak
      27121506 Ann of Clin Microbiol and Antimicrob, 2016 : 27(15)28
    • Hill JA, Boeckh M, Leisenring WM, Xie H, Adler AL, Huang M-L, Fann JR, Delaney C, Zerr DM
      Human herpesvirus 6B reactivation and delirium are frequent and associated events after cord blood transplantation
      26121112 Bone Marrow Transplant, 2015 Jun 29 : PMCID:PMC4486349
    • Hill J, Hall Sedlak K, Zerr DM, Huang M-L, Yeung C, Myerson D, Jerome KR, Boeckh MJ
      Prevalence of Chromosomally integrated human herpesvirus 6 in patients with herpesvirus 6-central nervous system dysfunction.
      25255164 Biology of Blood and Marrow Transplantation, 2015 Feb. : 21(2)371-3
    • Martin E.T, Kuypers J, McRoberts JP, Englund JA, Zerr DM
      Human Bocavirus 1 Primary Infection and Shedding in Infants.
      25632039 Journal of Infectious Diseases, 2015 Jan 28 : PMCID:PMC4539892
    • Strelitz G, Gritton J, Klein EJ, Bradford MC, Follmer K, Zerr DM, Englund JA, Opel DJ
      Parental vaccine hesitancy and acceptance of seasonal influenza vaccine in the pediatric emergency department
      25744225 Vaccine, 2015 : 8(33)1802-7
    • Boyle N, Magaret A, Stednick Z, Morrison A, Butler-Wu S, Zerr D, Rogers K, Podczervinski S, Cheng A, Wald A, Pergam S
      Evaluating risk factors for Clostridium difficile infection in adult and pediatric hematopoietic cell transplant recipients
      26473030 Antimicrobial Resistance and Infection Control, 2015 : 14(4)41 PMCID:PMC4606905
    • Kronman MP, Nielson HJ, Adler AL, Giefer MJ, Wahbeh G, Singh N, Zerr DM, Suskind DL
      Fecal microbiota transplantation via nasogastric tube for recurrent Clostridium difficile infection in pediatric patients.
      25162365 Journal of Pediatric Gastroenterology and Nutrition, 2015 Jan. : 60(1)23-6
    • Hill JA, Zerr DM
      Roseoloviruses in transplant recipients: clinical consequences and prospects for treatment and prevention trials.
      25285614 Current Opinion in Virology, 2014 Dec. : 953-60
    • Coffin SE, Blieger SB, Duggan C, Huskins WC, Milstone AM, Potter-Bynoe G, Bram R, Sandora TJ, Song X, Zerr DM, Lee GM
      Central Line-associated bloodstream infections in neonates with gastrointestinal conditions: developing a candidate definition for mucosal barrier injury bloodstream infections.
      25333434 Infection Control and Hospital Epidemiology, 2014 Nov. : 35(11)1391-9
    • Hill JA, Boeckh MJ, Sedlak RH, Jerome KR, Zerr DM
      Human herpesvirus 6 can be detected in cerebrospinal fluid without associated symptoms after allogeneic hematopoietic cell transplantation.
      25066883 Journal of Clinical Virology, 2014 Oct. : 61(2)289-92
    • Kronman MP, Zerr DM, Qin X, Englund J, Cornell C, Sanders JE, Myers J, Rayar J, Berry JE, Adler AL, Weissman SJ
      Intestinal Decontamination of Multidrug-resistant Klebsiella pneumoniae After Recurrent Infections in an Immunocompromised Host.
      25041704 Diagnostic Microbiology and Infectious Diseases, 2014 Sept. : 80(1)87-9
    • Purev E, Winkler T, Danner RL, Fahle GA, Cook L, Zerr DM, Jerome KR, Childs RW
      Engraftment of donor cells with germ-line integration of HHV6 mimics HHV6 reactivation following cord blood/haplo transplantation.
      25124787 Blood, 2014 Aug 14 : 124(7)1198-9
    • Adler AL, Smith J, Permut LC, McMullan DM, Zerr DM
      Significance of Positive Mediastinal Cultures in Pediatric Cardiovascular surgical procedure Patients Undergoing Delayed Sternal Closure.
      24881862 Annals of Thoracic Surgery, 2014 Aug. : 98(2)685-90
    • Zerr DM, Qin X, Oron AP, Adler AL, Wolter DJ, Berry JE, Hoffman L, Weissman SJ
      Pediatric Infection and Intestinal Carriage due to Extended-Spectrum-Cephalosporin-Resistant Enterobacteriaceae.
      24798269 Antimicrobial Agents and Chemotherapy, 2014 July : 58(7)3997-4004
    • Hill JA, Myerson D, Sedlak RH, Jerome KR, Zerr DM
      Hepatitis due to human herpesvirus 6B after hematopoietic cell transplantation and a review of the literature.
      24703390 Transplant Infectious Disease, 2014 June : 16(3)477-83
    • Safdar N, Anderson DJ, Braun BI, Carling P, Cohen S, Donskey C, Drees M, Harris A, Henderson DK, Huang SS, Juthani-Mehta M, Lautenbach E, Linkin DR, Meddings J, Miller LG, Milstone A, Morgan D, Sengupta S, Varman M, Yokoe D, Zerr DM
      The Evolving Landscape of Healthcare-Associated Infections: Recent Advances in Prevention and a Road map for Research.
      24709716 Infection Control and Hospital Epidemiology, 2014 May : 35(5)480-93
    • Sedlak RH, Cook L, Huang M-L, Magaret A, Zerr DM, Boeckh M, Jerome KR
      Identification of Chromosomally Integrated Human Herpesvirus 6 by Droplet Digital PCR.
      24594780 Clinical Chemistry, 2014 May : 60(5)765-72
    • Little ML, Qin X, Zerr DM, Scott J Weissman SJ
      Molecular epidemiology of colonizing and disease-causing Klebsiella pneumoniae in pediatric patients.
      24464691 Journal of Medical Microbiology, 2014 April : 63(Pt 4)610-6
    • Pollack AH, Kronman MP, Zhou C, Zerr DM
      Automated Screening of Hospitalized Children for Influenza Vaccination.
      24567840 Journal of Pediatric Infectious Disease Society, 2014 March : 3(1)7-14
    • Simon TD., Pope CE., Browd SR., Ojemann JG., Riva-Cambrin J, Mayer-Hamblett N, Rosenfeld M, Zerr DM, Hoffman L
      Evaluation of microbial bacterial and fungal diversity in cerebrospinal fluid shunt infection.
      24421877 PLoSOne, 2014 Jan 8 : 9(1)e83229 PMCID:PMC3885436
    • Payne DC, Baggs J, Zerr DM, Klein NP, Yih K, Glanz J, Curns AT, Weintraub E, Parashar UD
      Protective Association Between Rotavirus Vaccination and Childhood Seizures in the Year Following Vaccination in US Children.
      24265355 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013 Nov 20 : 58(2)173-7
    • Guzman-Cottrill JA, Ravin KA, Bryant KA, Zerr DM, Kociolek L, Siegel JD
      Infection prevention and control in residential facilities for pediatric patients and their families.
      24018919 Infection Control and Hospital Epidemiology, 2013 Oct. : 34(10)1003-41
    • Martin LD, Rampersad SE, Geiduschek J, Zerr DM, Weiss GK, Martin L
      Modification of Anesthesia Practice Reduces Catheter-Associated Bloodstream Infections: A Quality Improvement Initiative.
      23565609 Pediatr Anaesthesia, 2013 July : 23(7)588-96
    • Weissman SJ, Adler A, Qin X, Zerr DM
      Emergence of extended-spectrum -lactam resistance among Escherichia coli at a US academic childrens hospital is clonal at the sequence type level for CTX-M-15, but not for CMY-2.
      23434250 International journal of antimicrobial agents, 2013 May : 41(5)414-20 PMCID:PMC3627824
    • Milstone AM, Elward A, Song X, Zerr DM, Orscheln R, Speck K, Obeng D, Reich NG, Coffin SE, Perl TM, Pediatric SCRUB Trial Study Group
      Daily chlorhexidine bathing to reduce bacteraemia in critically ill children: a multicentre, cluster-randomised, crossover trial.
      23363666 Lancet, 2013 Mar 30 : 381(9872)1099-106
    • Xu M, Qin X, Astion ML, Rutledge JC, Simpson J, Jerome KR, Englund JA, Zerr DM, Migita RT, Rich S, Childs JC, Cent A, and Del Beccaro MA
      Implementation of Filmarray respiratory viral panel in a core laboratory improves testing turnaround time and patient care.
      23270907 American Journal of Clinical Pathology, 2013 Jan. : 139(1)118-23
    • Kronman MP, Gerber JS, Prasad PA, Adler A, Bass JA, Newland JG, Shah K, Zerr DM, Feng R, Coffin SE, Zaoutis TE
      Variation in Antibiotic Use in Children Hospitalized with Inflammatory Bowel Disease Exacerbation: a Multicenter Validation Study.
      23687581 Journal of the Pediatric Infectious Diseases Society, 2012 Dec. : 1(4)306-13
    • Qin X, Zerr DM, McNutt MA, Berry JE , Burns JL, and Kapur, RP
      Pseudomonas aeruginosa syntrophy in chronically colonized airways of cystic fibrosis patients.
      22964251 Antimicrobial Agents Chemotherapy, 2012 Nov. : 56(11)5971-81
    • Zerr DM, Boeckh M, Delaney C, Martin PJ, Xie H, Adler AL, Huang ML, Corey L, Leisenring WM
      HHV-6 reactivation and associated sequelae after hematopoietic cell transplantation.
      22641196 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2012 Nov. : 18(11)1700-8 PMCID:PMC3439599
    • Zerr DM
      Human herpesvirus 6 (HHV-6) disease in the setting of transplantation.
      22710317 Current opinion in infectious diseases, 2012 Aug. : 25(4)438-44
    • Alexander S, Nieder M, Zerr DM, Fisher BT, Dvorak CC, Sung L
      Prevention of bacterial infection in pediatric oncology: What do we know, what can we learn?
      22102612 Pediatric Blood Cancer, 2012 Jul 15 : 59(1)16-20
    • Fisher BT, Alexander S, Dvorak CC, Zaoutis TE, Zerr DM, Sung L
      Epidemiology and potential preventative measures for viral infections in children with malignancy and those undergoing hematopoietic cell transplantation.
      22102619 Pediatric Blood Cancer, 2012 Jul 15 : 59(1)11-5
    • Qin X, Galanakis E, Zerr DM, Weissman SJ
      Antibiotic options for treatment of pediatric infections with Enterobacteriaceae producing broad spectrum beta-lactamases.
      Anti-Infective Agents, 2012 July : 10130-5
    • Lundgren IS, Zhou C, Malone FR, McAfee NG, Gantt S, Zerr DM
      Central venous catheter repair is associated with an increased risk of bacteremia and central line-associated bloodstream infection in pediatric patients.
      22146741 The Pediatric infectious disease journal, 2012 April : 31(4)337-40 PMCID:PMC3305844
    • Guzman-Cottrill JA, Bryant KA, Zerr DM, Harris AA, Alexander ER, Boone Z, Siegel JD
      Infection Prevention and Control Guidance for Ronald McDonald Houses: A Needs Assessment.
      22314069 Infection Control and Hospital Epidemiology, 2012 March : 33299-301
    • Adler AL, Martin ET, Cohen G, Jeffries H, Gilbert M, Smith J, Zerr DM
      A comprehensive intervention associated with reduced surgical site infections among pediatric cardiovascular surgery patients, including those with delayed closure.
      Journal of the Pediatric Infectious Diseases Society, 2012 : 135-43
    • Little ML, Qin X, Zerr DM, Weissman SJ
      Molecular diversity in mechanisms of carbapenem resistance in paediatric Enterobacteriaceae.
      22055532 International Journal of Antimicrobial Agents, 2012 Jan. : 3952-7
    • Feemster KA, Leckerman K, Middleton M, Zerr DM, Elward A, Newland J, Asti L, Guth R, Selvarangan R, Zaoutis T, Coffin S
      Use of administrative data for the identification of laboratory-confirmed influenza infection: the validity of influenza-specific ICD-9 codes.
      Journal of the Pediatric Infectious Diseases Society, 2012
    • Zerr, DM
      Human herpesvirus 6 infection in hematopoietic cell transplant recipients.
      UpToDate, 2012 - 2014 : In: B. Ros
      http://www.uptodateonline.com
    • Soma VL, Qin X, Zhou C, Adler A, Berry JE, Zerr DM
      The effects of daily chlorhexidine bathing on cutaneous bacterial isolates: a pilot study.
      22573939 Infection and drug resistance, 2012 : 575-8 PMCID:PMC3346208
    • Martin ET, Qin X, Baden H, Migita R, Zerr DM
      Randomized double-blind crossover trial of Ultraviolet light-sanitized keyboards in a pediatric hospital.
      21624637 American Journal of infection Control, 2011 June : 39(5)433-35
    • Zerr DM, Fann JR, Breiger D, Boeckh M, Adler AL, Xie H, Delaney C, Huang ML, Corey L, Leisenring WM
      HHV-6 reactivation and its effect on delirium and cognitive functioning in hematopoietic cell transplantation recipients.
      21389320 Blood, 2011 May 12 : 117(19)5243-9 PMCID:PMC3109545
    • Kay M, Zerr DM, Englund JA, Cadwell B, Kuypers J, Swenson P, Kwan-Gett TS, Bell S, Duchin J
      Shedding of Pandemic (H1N1) 2009 virus among health care personnel, Seattle, Washington, USA.
      21470453 Emergency Infectious Disease, 2011 April : 17(4)639-44
    • Shaklee J, Zerr DM, Elward A, Newland J, Leckerman K, Asti L, Guth R, Bass J, Selvarangan R, Coffin S, Zaoutis T
      Improving Surveillance for Pediatric Clostridium difficile Infection: Derivation and Validation of an Accurate Case-finding Tool.
      21079527 Pediatric Infectious Disease Journal, 2011 March : 30(3)e38-40
    • Martin ET, Kerin T, Christakis DA, Blume HK, Gospe SM Jr, Vinje J, Bowen MD, Gentsch J, Zerr DM
      Redefining outcome of first seizures by acute illness.
      21098153 Pediatrics, 2010 Dec. : 126(6)e1477-84 PMCID:PMC3040576
    • Martin ET, Fairchok MP, Kuypers J, Magaret A, Zerr DM, Wald A, Englund JA
      Frequent and prolonged shedding of bocavirus in young children attending daycare.
      20415535 The Journal of infectious diseases, 2010 Jun 1 : 1625-32
    • Milstone AM, Bryant K, Huskins WC, Zerr DM
      The Past, Present, and Future of HAI Prevention in Pediatrics: Multidrug Resistant Organisms.
      Infection Control and Hospital Epidemiology, 2010 : 3118-21
    • Zerr DM
      Common Viral Infections of Childhood. In: Jerome K eds.
      Lennettes Laboratory Diagnosis of Viral Infections, 2010 : 4th ed(New York:)
    • Bryant K, Zerr DM, Huskins WC, Milstone AM
      The Past, Present, and Future of HAI Prevention in Pediatrics: Catheter-associated Bloodstream Infections.
      Infection Control and Hospital Epidemiology, 2010 : 3127-31
    • Martin ET, Taylor J, Kuypers J, Magaret A, Wald A, Zerr DM, Englund JA
      Detection of bocavirus in saliva of children with and without respiratory illness.
      Journal of Clinical Microbiology, 2009 Dec. : 47(12)4131-32 PMCID:PMC2786661
    • Razonable RR and Zerr DM
      AST Infectious Diseases Community of Practice. HHV-6, HHV-7, and HHV-8 in solid organ transplant recipients.
      American Journal of Transplantation, 2009 : 9(Suppl 4)S97-100
    • Stempel HE, Martin ET, Kuypers J, Englund JA, Zerr DM
      Multiple viral respiratory pathogens in children with bronchiolitis.
      18785966 Acta paediatrica (Oslo, Norway : 1992), 2009 Jan. : 123-6
    • Qin X, Zerr DM, Weissman SJ, Englund JA, Denno DM, Klein EJ, Tarr PI, Kwong J, Stapp JR, Tulloch LG, Galanakis E
      Prevalence and mechanisms of broad-spectrum beta-lactam resistance in Enterobacteriaceae: a children's hospital experience.
      18765688 Antimicrobial agents and chemotherapy, 2008 Nov. : 3909-14
    • Adler AL, Casper C, Boeckh M, Heath J, Zerr DM
      An outbreak of varicella with likely breakthrough disease in a population of pediatric cancer patients.
      18681813 Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America, 2008 Sept. : 866-70
    • Zerr DM, Englund JA, Robertson AS, Marcuse EK, Garrison MM, Christakis DA
      Hospital-based influenza vaccination of children: an opportunity to prevent subsequent hospitalization.
      18245426 Pediatrics, 2008 Feb. : 345-8
    • Posfay-Barbe KM, Zerr DM, Pittet D
      Infection control in paediatrics.
      18156087 The Lancet infectious diseases, 2008 Jan. : 19-31
    • Limaye S, Mastrangelo C, Zerr DM
      Monitoring Hospital-Associated Infections with Count Control Charts.
      Quality Engineering, 2008 : 20(4)404-413
    • Limaye S, Mastrangelo C, Zerr DM, Howard Jeffries
      A Statistical Approach to Reduce Hospital-Associated Infections.
      Quality Engineering, 2008 : 20(4)414-425
    • Gray GC, McCarthy T, Lebeck MG, Schnurr DP, Russell KL, Kajon AE, Landry ML, Leland DS, Storch GA, Ginocchio CC, Robinson CC, Demmler GJ, Saubolle MA, Kehl SC, Selvarangan R, Miller MB, Chappell JD, Zerr DM, Kiska DL, Halstead DC, Capuano AW, Setterquist SF, Chorazy ML, Dawson JD, Erdman DD
      Genotype prevalence and risk factors for severe clinical adenovirus infection, United States 2004-2006.
      17918073 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2007 Nov 1 : 1120-31
    • Rhoads MP, Magaret AS, Zerr DM
      Family saliva sharing behaviors and age of human herpesvirus-6B infection.
      17196254 The Journal of infection, 2007 June : 623-6
    • Kronman MP, Baden HP, Jeffries HE, Heath J, Cohen GA, Zerr DM
      An investigation of Aspergillus cardiac surgical site infections in 3 pediatric patients.
      17577481 American journal of infection control, 2007 June : 332-7
    • Baggett HC, Duchin JS, Shelton W, Zerr DM, Heath J, Ortega-Sanchez IR, Tiwari T
      Two nosocomial pertussis outbreaks and their associated costs - King County, Washington, 2004.
      17464912 Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America, 2007 May : 537-43
    • Goldin AB, Sawin RS, Garrison MM, Zerr DM, Christakis DA
      Aminoglycoside-based triple-antibiotic therapy versus monotherapy for children with ruptured appendicitis.
      17473090 Pediatrics, 2007 May : 905-11
    • Zerr DM
      Human herpesvirus 6 and central nervous system disease in hematopoietic cell transplantation.
      17276370 Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2006 Dec. : S52-6
    • Zerr DM, Frenkel LM, Huang ML, Rhoads M, Nguy L, Del Beccaro MA, Corey L
      Polymerase chain reaction diagnosis of primary human herpesvirus-6 infection in the acute care setting.
      17011318 The Journal of pediatrics, 2006 Oct. : 480-5
    • Zerr DM
      Human herpesvirus 6: a clinical update.
      16732999 Herpes : the journal of the IHMF, 2006 May : 20-4
    • Heath J, Zerr DM
      Infection Acquired in the Nursery: Epidemiology and Control. In: Remington JS, Klein JO, Wilson CB, Baker CJ, eds.
      Infectious Diseases of the Fetus and Newborn Infant, 2006 : 6th ed(Philadelph)
    • Zerr DM, Blume HK, Berg AT, Del Beccaro MA, Gospe SM Jr, Allpress AL, Christakis DA
      Nonfebrile illness seizures: a unique seizure category?
      15946338 Epilepsia, 2005 June : 952-5
    • Zerr DM, Allpress AL, Heath J, Bornemann R, Bennett E
      Decreasing hospital-associated rotavirus infection: a multidisciplinary hand hygiene campaign in a children's hospital.
      15876937 The Pediatric infectious disease journal, 2005 May : 397-403
    • Zerr DM
      Alcohol hand rub: a simple solution in search of champions.
      15867129 Archives of pediatrics and adolescent medicine, 2005 May : 502-3
    • Yeung LC, Cunningham ML, Allpress AL, Gruss JS, Ellenbogen RG, Zerr DM
      Surgical site infections after pediatric intracranial surgery for craniofacial malformations: frequency and risk factors.
      15792512 Neurosurgery, 2005 April : 733-9; discussion 733-9
    • Zerr DM, Garrison MM, Allpress AL, Heath J, Christakis DA
      Infection control policies and hospital-associated infections among surgical patients: variability and associations in a multicenter pediatric setting.
      15805339 Pediatrics, 2005 April : e387-92
    • Zerr DM, Corey L, Kim HW, Huang ML, Nguy L, Boeckh M
      Clinical outcomes of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation.
      15824982 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005 Apr 1 : 932-40
    • Christakis DA, Cowan CA, Garrison MM, Molteni R, Marcuse E, Zerr DM
      Variation in inpatient diagnostic testing and management of bronchiolitis.
      15805359 Pediatrics, 2005 April : 878-84
    • Benson C, Gantt S, Zerr DM, Qin X, Abe P
      Use of 16S ribosomal DNA polymerase chain reaction to identify Haemophilus influenzae type b as the etiology of pericarditis in an infant.
      15750478 The Pediatric infectious disease journal, 2005 March : 287-8
    • Zerr DM, Meier AS, Selke SS, Frenkel LM, Huang ML, Wald A, Rhoads MP, Nguy L, Bornemann R, Morrow RA, Corey L
      A population-based study of primary human herpesvirus 6 infection.
      15728809 The New England journal of medicine, 2005 Feb 24 : 768-76
    • Boeckh M, Erard V, Zerr D, Englund J
      Emerging viral infections after hematopoietic cell transplantation.
      Pediatric Transplantation, 2005 : 9(Suppl 7)48-50
    • Zerr, DM
      Effect of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation
      Contagion, 2005 : 2352-7
    • Allpress AL, Rosenthal GL, Goodrich KM, Lupinetti FM, Zerr DM
      Risk factors for surgical site infections after pediatric cardiovascular surgery.
      15014298 The Pediatric infectious disease journal, 2004 March : 231-4
    • Bornemann R, Zerr DM, Heath J, Koehler J, Grandjean M, Pallipamu R, Duchin J
      An outbreak of Salmonella serotype Saintpaul in a children's hospital.
      12452295 Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America, 2002 Nov. : 671-6
    • Byington CL, Zerr DM, Taggart EW, Nguy L, Hillyard DR, Carroll KC, Corey L
      Human herpesvirus 6 infection in febrile infants ninety days of age and younger.
      12442018 The Pediatric infectious disease journal, 2002 Nov. : 996-9
    • Zerr DM, Garrison M, Marr KA, Christakis DA
      A metaanalysis of amphotericin B versus fluconazole for treatment of invasive Candida infections.
      Journal of Clinical Outcomes Management, 2002 April : 9191-6
    • Zerr DM, Yeung LC, Obrigewitch RM, Huang ML, Frenkel LM, Corey L
      Case report: primary human herpesvirus-6 associated with an afebrile seizure in a 3-week-old infant.
      11793391 Journal of medical virology, 2002 March : 66(3)384-7
    • Zerr DM, Gupta D, Huang ML, Carter R, Corey L
      Effect of antivirals on human herpesvirus 6 replication in hematopoietic stem cell transplant recipients.
      11774077 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2002 Feb 1 : 34(3)309-17
    • Zerr DM, Gooley TA, Yeung L, Huang M-L, Carpenter P, Wade J, Corey L, Anasetti C
      Human Herpesvirus 6 reactivation and encephalitis in allogeneic bone marrow transplant recipients.
      11512080 Clinical Infectious Diseases, 2001 Sept. : 33(6)763-771
    • Zerr DM, Heath J, Riggert D, Marcuse E
      Congenital Rubella: Infection Control Problem
      Pediatrics, 2001 : 1081389
    • Zerr DM, Huang M-L, Corey L, Erickson M, Parker HL, Frenkel LM
      Sensitive method for detection of human herpesviruses 6 and 7 in saliva collected in field studies.
      10790134 Journal of Clinical Microbiology, 2000 May : 38(5)1981-3
    • Davis RL, Hasselquist MB, Cardenas V, Zerr DM, Kramer J, Zavitkovsky A, Schuchat A
      Introduction of the new Centers for Disease Control and prevention group B streptococcal prevention guideline at a large west coast health maintenance organization.
      11262460 American Journal of Obstetrics and Gynecology, 2000 March : 184(4)603-10
    • Zerr DM, Alexander ER, Duchin JS, Koutsky LA, Rubens CE
      Necrotizing fasciitis during primary varicella
      Pediatrics, 2000 : 1051373-75
    • Christakis DA, Harvey E, Zerr DM, Feudtner C, Wright JA, Connell FA.
      A Trade-off analysis of routine newborn circumcision.
      10617731 Pediatrics, 2000 Jan. : 105246-9
    • Christakis DA, Stewart L, Bibus D, Stout J, Zerr DM, MacDonald J, Gale J
      Providers' perceptions of an immunization registry.
      10490059 American Journal of Preventative Medication, 1999 Aug. : 17(2)147-50
    • Zerr DM, Alexander ER, Duchin JS, Koutsky LA, Rubens CE
      A case-control study of necrotizing fasciitis during primary varicella.
      10103303 Pediatrics, 1999 April : 103783-90
    • Zerr DM, Cummings P, DelBeccaro MA.
      Predictors of physician compliance with a published guideline on the management of febrile infants.
      10093943 Pediatric Infectious Diseases, 1999 March : 18(3)232-8
    • Zerr DM, Frenkel LM
      Advances in antiviral therapy
      Current Opinion in Pediatrics, 1999 : 1121-7
    • Zerr DM, Rubens CE
      NSAIDs and necrotizing fasciitis
      Pediatric Infectious Diseases (concise reviews), 1999 : 18724-5
    • Zerr DM, Corey L
      Exploring Epstein-Barr virus
      Herpes, 1998 : 5(3)
    • Zerr D, Hall JC, Roshbash M, Siwicki KK
      Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila.
      2117644 Journal of Neuroscience, 1990 Aug. : 10(8)2749-2762
    • Tobin NH, Campbell AJP , Zerr DM, Melvin AJ
      Life-Threatening Viral Disease and Its Treatment. In: Fuhrman BP, Zimmerman JJ, eds.
      Pediatric Critical Care. 4th ed, St Louis:

    Book Chapters

    • Zerr DM, Razonable RR
      Human Herpesvirus 6. In: Singh N, ed.
      Transplant Infections, 2012 : ESun Techn
      www.antimicrobe.org
    • Zerr DM, Tobin NH, Melvin AJ
      Life-Threatening Viral Disease and Its Treatment. In: Fuhrman BP, Zimmerman JJ, eds.
      Pediatric Critical Care, 2006 : 3rd ed(St Louis:)

  • Presentations

    Presentation Title Event Location Date
    Implementing Infection Prevention Practices in Diverse Settings IDWeek San Diego, CA Oct. 2015
    Improving Outcomes in Hospitalized Children IDWeek San Diego, CA Oct. 2015
    Roseoloviruses in Immune Compromised Patients: Impacts and Prospects for Clinical Trials NIAID (NIH) Grand Rounds NIH Nov 14, 2014
    Prevention and Management of Cardiovascular Device Infections IDWeek Symposium title: Surgical Device Infections in Children Philadelphia, PA Oct. 2014
    Prevention and Treatment of Cardiovascular Device Infections Ron Lemire Symposium on Sepsis Seattle, WA Oct. 2014
    Thorny Issues in Infection Prevention IDWeek Philadelphia, PA Oct. 2014
    Roseoloviruses in Immune Compromised Patients NIH Roseolovirus Workshop NIH June 2014
    HHV6 encephalitis in immunocompetent and in immunocompromised hosts Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 2012 San Francisco, CA Sept. 2012
    HHV-6 Disease in Transplantation: Viral Integration, Disease Manifestations and Management 49th Annual Meeting of Infectious Disease Society of America (IDSA) Boston, MA Oct. 2011
    Viral Respiratory Infections Fifth Decennial International Conference on Healthcare-Associated Infections Atlanta, GA March 2010
    Evidence-Based Monitoring for Viral Infections in Transplant Recipients: Who, When, What Specimen, What Assay?: HHV-6 Joint meeting of ICAAC/IDSA Washington DC Oct. 2008
    Protecting children from healthcare-associated infection: How are we doing? Grand Rounds, Department of Pediatrics, Childrens Hospital Seattle, WA Nov. 2007
    Human Herpesvirus 6 Infection: A System to Identify Primary Infection Institute of Translational Health Sciences Symposia: Utilizing Saliva in Translational Research University of Washington Sep 11, 2007
    HHV-6: What Does a Positive PCR Mean? Stem Cell Transplantation in Children: Current Results and Controversies San Diego, CA Jan. 2007
    Human herpesvirus 6: Cradle to Transplant Recipient General Clinical Research Center: Second Annual Symposium University of Washington Sept. 2006
    The clinical impact of HHV-6: beyond roseola 31st International Herpesvirus Workshop Seattle, WA July 2006
    Human Herpesvirus 6 Infection in Infancy and Childhood Not All Roseola and Febrile Seizures 44th Annual Meeting of Infectious Disease Society of America (IDSA) Toronto, Ontario, Canada 2006
    HHV-6, 7, and 8: From Cradle to Transplant Recipient 45th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Washington DC Dec. 2005
    HHV-6 Associated CNS Dysfunction Following HSCT Grand Rounds, Department of Neurology University of Washington March 2005
    HHV-6, the HCT Recipient, and Protocol 1831 Grand Rounds, Seattle Cancer Care Alliance FHCRC Dec. 2004
    HHV-6 Infections in Immunocompromised Patients Pediatric Academic Societies annual national meeting San Francisco, CA 2004
    HHV-6 and Central Nervous System Dysfunction in the HSCT Recipient Grand Rounds, Seattle Cancer Care Alliance FHCRC Nov. 2003
    Improving Patient Safety: The Infection Control Perspective Grand Rounds, Department of Pediatrics, Childrens Hospital Seattle, WA Nov. 2002
    HHV-6 Reactivation and Disease in BMT Recipients Grand Rounds, Seattle Cancer Care Alliance FHCRC Dec. 2000
    Human Herpesvirus 6 and Human Herpesvirus 7 Grand Rounds, Department of Laboratory Medicine University of Washington Nov. 1999

  • Research Funding

    Grant Title Grantor Amount Award Date
    Impact of Daily Bathing with Chlorhexidine Impregnated Cloths on Nosocomial Infections in the Pediatric Intensive Care Unit Sage Products, Inc. $100,000.00 Sep 1, 2009 - Jul 31, 2012
    HHV-6 and CNS disease following stem cell transplant NIH/NIAID $278,321.00 Sep 1, 2009 - Jun 30, 2010
    National surveillance of emerging MDR in pediatric Enterobacteriaceae infections NIH/NIAID $378,005.00 Aug 11, 2009
    Infection Control of Keyboards (ICK) Study: A Randomized, Blinded, Multi-Center Study of Ultraviolet Light Decontamination Vioguard LLC $114,000.00 Jun 1, 2009 - Jan 31, 2011
    Emerging MDR in pediatric Enterobacteriaceae infections CCTR Pediatric Pilot Award $20,000.00 Dec 1, 2008 - Nov 30, 2009
    HHV-6 and CNS disease following stem cell transplant NIH/NIAID $250,000.00 Jul 1, 2004 - Jun 30, 2011
    Viral Pathogens and First Time Seizures in the Setting of Illness Private Donation $60,000.00 Jun 30, 2003 - Jul 1, 2010

Overview

Board Certification(s)

Pediatric Infectious Diseases

Medical/Professional School

Temple University School of Medicine, Philadelphia, PA
University of Washington School of Public Health, Seattle, WA

Fellowship

University of Washington, Seattle, WA

Clinical Interests

Viral infections in healthy children and immunocompromised hosts and healthcare associated infections

Research Description

My research focuses on the epidemiology of infectious diseases in healthy and immunocompromised hosts. A particular focus areas include human herpesvirus 6 (HHV-6) infections in immunocompromised populations. I am also interested in studying the epidemiology and prevention of healthcare-associated infections in pediatrics.

Research Focus Area

Epidemiology, Host: Pathogen Interaction