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Michael A. Portman, MD

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Michael A. Portman, MD

Cardiology

On staff since October 1992

Children's Title: Director, Pediatric Cardiovascular Research

Academic Title: Professor, Pediatrics

Research Center: Center for Developmental Therapeutics

"Unlocking the secrets of heart disease in children both at the bench and at the bedside, and then developing new diagnostic and treatment approaches is most rewarding. In that way, my work extends not only to the children I personally treat but also to those cared for by other physicians."

Overview

Board Certification(s)
Pediatric Cardiology
Pediatrics
Medical/Professional School
University of Cincinnati College of Medicine, Cincinnati
Fellowship
Pediatric Cardiology, Case Western Reserve University, Cleveland
Clinical Interests

Cell metabolism, biomedicine, MRI

Research Description

We also perform research in Kawasaki Disease, which is an inflammatory syndrome attacking coronary arteries in children. Our work includes drug studies in animal models, and pharmacogenomic studies in patients. We are also performing clincial trials in patients.

We study cardiac metabolism and the impact of changing substrate utilization on the heart during development and during pathological states such as heart failure and cardiopulmonary bypass. Thyroid regulation of metabolism is a primary interest. Work is translational and progresses from basic benchtop studies to mice to large animals to the bedside.

Lab URL

http://www.seattlechildrens.org/research/developmental-therapeutics/portman-research-group/

Research Focus Area

Cardiology

Publications

Extracorporeal membrane oxygenation promotes long chain fatty acid oxidation in the immature swine heart in vivo.
Journal of molecular and cellular cardiology , 2013 Sep: 62144-52
Myocardial oxidative metabolism and protein synthesis during mechanical circulatory support by extracorporeal membrane oxygenation.
American journal of physiology. Heart and circulatory physiology , 2013 Feb 1: 304(3)H406-14
C-Myc induced compensated cardiac hypertrophy increases free fatty acid utilization for the citric acid cycle.
Journal of molecular and cellular cardiology , 2013 Feb: 55156-64
Kawasaki disease and soy: potential role for isoflavone interaction with Fc receptors.
Pediatric research , 2013 Feb: 73(2)130-4
Triiodothyronine supplementation and cytokines during cardiopulmonary bypass in infants and children.
The Journal of thoracic and cardiovascular surgery , 2012 Oct: 144(4)938-943.e2
Rare copy number variants in isolated sporadic and syndromic atrioventricular septal defects.
American journal of medical genetics. Part A , 2012 Jun: 158A(6)1279-84
Role of activating FcR gene polymorphisms in Kawasaki disease susceptibility and intravenous immunoglobulin response.
Circulation. Cardiovascular genetics , 2012 Jun: 5(3)309-16
Triiodothyronine increases myocardial function and pyruvate entry into the citric acid cycle after reperfusion in a model of infant cardiopulmonary bypass.
American journal of physiology. Heart and circulatory physiology , 2012 Mar 1: 302(5)H1086-93
The adaptor-related protein complex 2, alpha 2 subunit (AP22) gene is a peroxisome proliferator-activated receptor cardiac target gene.
The protein journal , 2012 Jan: 31(1)75-83
Functional FCGR2B gene variants influence intravenous immunoglobulin response in patients with Kawasaki disease.
The Journal of allergy and clinical immunology , 2011 Sep: 128(3)677-80
Prospective open-label trial of etanercept as adjunctive therapy for kawasaki disease.
The Journal of pediatrics , 2010 Dec: 157(6)960-966.e1
Genetic associations with mountain sickness in Han and Tibetan residents at the Qinghai-Tibetan Plateau.
Clinica chimica acta; international journal of clinical chemistry , 2010 Oct 9: 1466-73
Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin.
Pharmacogenetics and genomics , 2010 Sep 18
Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC): a multicenter placebo-controlled randomized trial: age analysis.
Circulation , 2010 Sep 14: S224-33
Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice.
American journal of physiology. Heart and circulatory physiology , 2010 Sep: H868-75
Prospective Open-Label Trial of Etanercept as Adjunctive Therapy for Kawasaki Disease.
The Journal of pediatrics , 2010 Jul 26
Thyroid hormone regulation of perinatal cardiovascular function.
Seminars in perinatology , 2008 Dec: 419-22
Superior cardiac function via anaplerotic pyruvate in the immature swine heart after cardiopulmonary bypass and reperfusion.
American journal of physiology. Heart and circulatory physiology , 2008 Dec: H2315-20
Cardioselective dominant-negative thyroid hormone receptor (Delta337T) modulates myocardial metabolism and contractile efficiency.
American journal of physiology. Endocrinology and metabolism , 2008 Aug: E420-7
Rapid progressive central cooling to 29 degrees C by extracorporeal circuit preserves cardiac function and hemodynamics in immature swine.
Resuscitation , 2008 Mar: 443-8
Thyroid hormone regulation of heart metabolism.
Thyroid : official journal of the American Thyroid Association , 2008 Feb: 217-25
Moderate hypothermia (30 degrees C) maintains myocardial integrity and modifies response of cell survival proteins after reperfusion.
American journal of physiology. Heart and circulatory physiology , 2007 Oct: H2119-28
The dominant negative thyroid hormone receptor beta-mutant {Delta}337T alters PPAR{alpha} signaling in heart.
American journal of physiology. Endocrinology and metabolism , 2007 Feb: E453-60
Short-cycle hypoxia in the intact heart: hypoxia-inducible factor 1alpha signaling and the relationship to injury threshold.
American journal of physiology. Heart and circulatory physiology , 2007 Jan: H333-41
Molecular mechanisms of cross-talk between thyroid hormone and peroxisome proliferator activated receptors: focus on the heart.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy , 2006 Dec: 463-9
Thyroid hormone receptor isoforms localize to cardiac mitochondrial matrix with potential for binding to receptor elements on mtDNA.
Mitochondrion , 2006 Jun: 143-8
Thyroid hormone controls myocardial substrate metabolism through nuclear receptor-mediated and rapid posttranscriptional mechanisms.
American journal of physiology. Endocrinology and metabolism , 2006 Feb: E372-9
Thyroid hormone interacts with PPARalpha and PGC-1 during mitochondrial maturation in sheep heart.
American journal of physiology. Heart and circulatory physiology , 2005 Nov: H2258-64
Direct action of T3 on phosphorylation potential in the sheep heart in vivo.
American journal of physiology. Heart and circulatory physiology , 2005 May: H2484-90
Effect of triiodothyronine on gene transcription during cardiopulmonary bypass in infants with ventricular septal defect.
The American journal of cardiology , 2005 Mar 15: 787-9
The Triiodothyronine for Infants and Children Undergoing Cardiopulmonary Bypass (TRICC) study: design and rationale.
American heart journal , 2004 Sep: 393-8
Hypothermia preserves myocardial function and mitochondrial protein gene expression during hypoxia.
American journal of physiology. Heart and circulatory physiology , 2003 Jul: H212-9
Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysis.
Journal of applied physiology (Bethesda, Md. : 1985) , 2002 May: 2200-7
The adenine nucleotide translocator: regulation and function during myocardial development and hypertrophy.
Clinical and experimental pharmacology & physiology , 2002 Apr: 334-8

Presentations

Presentations TitleEventLocationDate
Etanercept for Kawasaki DiseaseAnnual Meeting of the Western Society of Pediatric CardiologyYosemite CAJan. 1, 2009
Cardiology Grand RoundsUniversity of IllinoisChicago, ILJan. 1, 2009

Research Funding

Grant TitleGrantorAmountAward Date
Thyroid Control of Myocardial Metabolism in AgingNIH/NIA $439,000.00April 1, 2010
Metabolism During Mechanical Circulatory Support in the Developing HeartNIH/NHLBI $1,559,000.00July 1, 2009
Triostat in Children during Cardiopulmonary Bypass: Orphan Products Development Grant FDAApril 1, 2009
Etanercept for Acute Kawasaki DiseaseFDA $1,600,000.00Feb. 15, 2009
Role of Fc-gamma Receptor Polymorphisms in Determining IVIG Response in Kawasaki DiseaseThrasher Foundation $388,000.00Jan. 1, 2008
Fcr Mutations in Kawasaki Disease NIH/NHLBI $439,000.00June 1, 2007
Cell Metabolism & Myc Induced Growth, Death, & NeoplasiaNIH/NCI April 1, 2005
UW Stipends for Training Aspiring Researchers NIH/NHLBIApril 1, 2004

Primary Office

Seattle Children's
RC.2.820 - Cardiology Administration
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2266

Additional Offices

Seattle Children's
RC.2.820 - Cardiology-Heart Ctr
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2015
Seattle Children's Bellevue Clinic and Surgery Center
CB-11
1500 - 116th Ave NE
Bellevue, WA 98004
425-454-4644
Seattle Children's Everett
CE - Suite 100
900 Pacific Ave
Everett, WA 98201
425-304-6080

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