K Scott Baker, MD, MS

K Scott Baker, MD, MS

Cancer and Blood Disorders Center, Non-Malignant Transplant Program, Pediatric Blood and Marrow Transplant Program

On staff since April 2009

Children's Title: Section Chief, Blood and Marrow Transplantation

Academic Title: Professor, Department of Pediatrics, University of Washington School of Medicine

Research Title: Professor, Clinical Research Division, Fred Hutch Cancer Center

Foundation Title: Gerald and Gloria Swanson Family Endowed Chair in Pediatric Bone Marrow Transplantation Research

Research Center: Ben Towne Center for Childhood Cancer Research

"As a physician involved in the field of blood and marrow transplantation, I have the opportunity to offer patients and parents hope for the cure of many potentially life-threatening diseases both malignant and nonmalignant. That fact, along with the intensity of transplant as a treatment, creates a strong bond between physician and patient. The reward for doing this comes many years later, when I receive a high-school or college graduation announcement and realize that what I did gave that person a chance for life."

  • Biography

    K. Scott Baker, MD, MS is a member in the Clinical Research Division of the Fred Hutchinson Cancer Center, professor in the Department of Pediatrics at the University of Washington in Seattle, Washington, and director of the Pediatric Blood and Marrow Transplant Program and Cancer Survivorship Program at Seattle Children's Hospital and Fred Hutchinson.

    This program is one of only eight centers in the US designated by the Lance Armstrong Foundation as a LIVESTRONG Survivorship Center of Excellence. He is a nationally recognized expert in the field of hematopoietic cell transplantation (HCT) and in cancer survivorship and serves on the Cancer Control and Late Effects steering committee of the Childrens Oncology Group and is a member of the Late Effects and Health Policy Committees for the Center for International Blood and Marrow Transplant Research.

    Dr. Baker's research interests are in the acute and long term-effects of HCT and are focused on the study of treatment related acute and long-term complications in survivors after transplant. This research forms the basis for his current grant support in which the incidence, risk factors, and characteristics of cardiac, pulmonary, renal, endocrine, reproductive late effects and quality of life outcomes in survivors are being studied. Additional studies are examining the "metabolic syndrome" and the early development of cardiovascular risk factors and diabetes in HCT survivors.

    Dr. Baker is the principal investigator for Fred Hutchinson and Seattle Children's Hospital for participation in the multi-institutional Childhood Cancer Survivor Study, which follows nearly 20,000 childhood cancer survivors. This study has made a tremendous number of scientific discoveries regarding the long-term outcomes in survivors after childhood cancer.

    Dr. Baker also serves as the principal investigator for several HCT clinical trials, particularly for treatment of children with hemophagoytic lymphohistiocytosis (HLH), Langerhans Cell Histiocytosis (LCH) and other primary immune deficiencies. For these patients, a novel type of transplantation designed to make HCT for patients with these disorders safer by utilizing a reduced intensity transplant preparative regimen is being investigated.

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  • Awards and Honors

    Award Name Award Description Awarded By Award Date
    SEATTLE TOP DOCTOR - 2022 Seattle Magazine 2022
    SEATTLE'S TOP DOCTOR - 2017 Seattle Magazine 2017
    SEATTLE MAGAZINE TOP DOCTOR - 2016 Seattle Magazine 2016

  • Publications

    Other Publications

    • McAvoy S, Baker KS, Mulrooney D, Blaes A, Arora M, Burns LJ, Majhail NS
      Corticosteroid dose as a risk factor for avascular necrosis of the bone after hematopoietic cell transplantation.
      20302963 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2010 Sept. : 1231-6
    • Armenian SH, Sun CL, Teh JB, Arora M, Baker KS, Francisco L, Forman SJ, Bhatia S
      Ethnic differences in chronic health conditions after hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study.
      20564108 Cancer, 2010 Sep 1 : 4152-9
    • Sun CL, Francisco L, Kawashima T, Leisenring W, Robison LL, Baker KS, Weisdorf DJ, Forman SJ, Bhatia S
      Prevalence and predictors of chronic health conditions after hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study.
      20656930 Blood, 2010 Jul 23
    • Chow EJ, Simmons JH, Roth CL, Baker KS, Hoffmeister PA, Sanders JE, Friedman DL
      Increased cardiometabolic traits in pediatric survivors of acute lymphoblastic leukemia treated with total body irradiation.
      20685399 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2010 May 31
    • Hoffmeister PA, Hingorani SR, Storer BE, Baker KS, Sanders JE
      Hypertension in long-term survivors of pediatric hematopoietic cell transplantation.
      19961945 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2010 April : 515-24
    • Baker KS, Bresters D, Sande JE
      The burden of cure: long-term side effects following hematopoietic stem cell transplantation (HSCT) in children.
      20307723 Pediatric clinics of North America, 2010 Feb. : 323-42
    • Baker KS, Armenian S, Bhatia S
      Long-term consequences of hematopoietic stem cell transplantation: current state of the science.
      19782145 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2010 Jan. : S90-6
    • Smith AR, Gross TG, Baker KS
      Transplant outcomes for primary immunodeficiency disease.
      20109615 Seminars in hematology, 2010 Jan. : 79-85
    • Kaste SC, Goodman P, Leisenring W, Stovall M, Hayashi RJ, Yeazel M, Beiraghi S, Hudson MM, Sklar CA, Robison LL, Baker KS
      Impact of radiation and chemotherapy on risk of dental abnormalities: a report from the Childhood Cancer Survivor Study.
      19834960 Cancer, 2009 Dec 15 : 5817-27
    • Baker KS, Davies SM, Majhail NS, Hassebroek A, Klein JP, Ballen KK, Bigelow CL, Frangoul HA, Hardy CL, Bredeson C, Dehn J, Friedman D, Hahn T, Hale G, Lazarus HM, LeMaistre CF, Loberiza F, Maharaj D, McCarthy P, Setterholm M, Spellman S, Trigg M, Maziarz RT, Switzer G, Lee SJ, Rizzo JD
      Race and socioeconomic status influence outcomes of unrelated donor hematopoietic cell transplantation.
      19896078 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2009 Dec. : 1543-54
    • Majhail NS, Challa TR, Mulrooney DA, Baker KS, Burns LJ
      Hypertension and diabetes mellitus in adult and pediatric survivors of allogeneic hematopoietic cell transplantation.
      19660723 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2009 Sept. : 1100-7
    • Tomblyn MB, Arora M, Baker KS, Blazar BR, Brunstein CG, Burns LJ, DeFor TE, Dusenbery KE, Kaufman DS, Kersey JH, MacMillan ML, McGlave PB, Miller JS, Orchard PJ, Slungaard A, Tomblyn MR, Vercellotti GM, Verneris MR, Wagner JE, Weisdorf DJ
      Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcome.
      19581540 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009 Aug 1 : 3634-41
    • Yi JS, Moertel CL, Baker KS
      Homozygous alpha-thalassemia treated with intrauterine transfusions and unrelated donor hematopoietic cell transplantation.
      19364562 The Journal of pediatrics, 2009 May : 766-8
    • Hunger SP, Loh KM, Baker KS, Schultz KR
      Controversies of and unique issues in hematopoietic cell transplantation for infant leukemia.
      19147083 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2009 Jan. : 79-83
    • Thomas IH, Donohue JE, Ness KK, Dengel DR, Baker KS, Gurney JG
      Bone mineral density in young adult survivors of acute lymphoblastic leukemia.
      18932250 Cancer, 2008 Dec 1 : 3248-56
    • Prasad PK, Sun CL, Baker KS, Francisco L, Forman S, Bhatia S, Shankar SM
      Health care utilization by adult Hispanic long-term survivors of hematopoietic stem cell transplantation: report from the Bone Marrow Transplant Survivor Study.
      18831512 Cancer, 2008 Nov 15 : 2724-33
    • Robien K, Ness KK, Klesges LM, Baker KS, Gurney JG
      Poor adherence to dietary guidelines among adult survivors of childhood acute lymphoblastic leukemia.
      18989158 Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology, 2008 Nov. : 815-22
    • Krishnamurti L, Kharbanda S, Biernacki MA, Zhang W, Baker KS, Wagner JE, Wu CJ
      Stable long-term donor engraftment following reduced-intensity hematopoietic cell transplantation for sickle cell disease.
      18940682 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2008 Nov. : 1270-8
    • Johnson L, Orchard PJ, Baker KS, Brundage R, Cao Q, Wang X, Langer E, Farag-El Maasah S, Ross JA, Remmel R, Jacobson PA
      Glutathione S-transferase A1 genetic variants reduce busulfan clearance in children undergoing hematopoietic cell transplantation.
      18635758 Journal of clinical pharmacology, 2008 Sept. : 1052-62
    • Harker-Murray PD, Thomas AJ, Wagner JE, Weisdorf D, Luo X, DeFor TE, Verneris MR, Dusenbery KE, MacMillan ML, Tolar J, Baker KS, Orchard PJ
      Allogeneic hematopoietic cell transplantation in children with relapsed acute lymphoblastic leukemia isolated to the central nervous system.
      18489994 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2008 June : 685-92
    • Baker KS, Fraser CJ
      Quality of life and recovery after graft-versus-host disease.
      18503996 Best practice & research. Clinical haematology, 2008 June : 333-41
    • Perez-Albuerne ED, Eapen M, Klein J, Gross TJ, Lipton JM, Baker KS, Woolfrey A, Kamani N
      Outcome of unrelated donor stem cell transplantation for children with severe aplastic anemia.
      18307564 British journal of haematology, 2008 April : 216-23
    • Dengel DR, Ness KK, Glasser SP, Williamson EB, Baker KS, Gurney JG
      Endothelial function in young adult survivors of childhood acute lymphoblastic leukemia.
      18176175 Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology, 2008 Jan. : 20-5
    • Ness KK, Baker KS, Dengel DR, Youngren N, Sibley S, Mertens AC, Gurney JG
      Body composition, muscle strength deficits and mobility limitations in adult survivors of childhood acute lymphoblastic leukemia.
      17091482 Pediatric blood & cancer, 2007 Dec. : 975-81
    • Perkins JL, Kunin-Batson AS, Youngren NM, Ness KK, Ulrich KJ, Hansen MJ, Petryk A, Steinberger J, Anderson FS, Baker KS
      Long-term follow-up of children who underwent hematopoeitic cell transplant (HCT) for AML or ALL at less than 3 years of age.
      17474113 Pediatric blood & cancer, 2007 Dec. : 958-63
    • Bhatia S, Francisco L, Carter A, Sun CL, Baker KS, Gurney JG, McGlave PB, Nademanee A, O'Donnell M, Ramsay NK, Robison LL, Snyder D, Stein A, Forman SJ, Weisdorf DJ
      Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study.
      17671231 Blood, 2007 Nov 15 : 3784-92
    • Gurney JG, Donohue JE, Ness KK, O'Leary M, Glasser SP, Baker KS
      Health knowledge about symptoms of heart attack and stroke in adult survivors of childhood acute lymphoblastic leukemia.
      17662616 Annals of epidemiology, 2007 Oct. : 778-81
    • Majhail NS, Ness KK, Burns LJ, Sun CL, Carter A, Francisco L, Forman SJ, Bhatia S, Baker KS
      Late effects in survivors of Hodgkin and non-Hodgkin lymphoma treated with autologous hematopoietic cell transplantation: a report from the bone marrow transplant survivor study.
      17889351 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2007 Oct. : 1153-9
    • Adamkiewicz TV, Szabolcs P, Haight A, Baker KS, Staba S, Kedar A, Chiang KY, Krishnamurti L, Boyer MW, Kurtzberg J, Wagner JE, Wingard JR, Yeager AM
      Unrelated cord blood transplantation in children with sickle cell disease: review of four-center experience.
      17663687 Pediatric transplantation, 2007 Sept. : 641-4
    • Shankar SM, Carter A, Sun CL, Francisco L, Baker KS, Gurney JG, Weisdorf DG, Forman SJ, Robison LL, Grant M, Bhatia S
      Health care utilization by adult long-term survivors of hematopoietic cell transplant: report from the Bone Marrow Transplant Survivor Study.
      17416780 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007 April : 834-9
    • Brunstein CG, Baker KS, Wagner JE
      Umbilical cord blood transplantation for myeloid malignancies.
      17255794 Current opinion in hematology, 2007 March : 162-9
    • Baker KS, Ness KK, Steinberger J, Carter A, Francisco L, Burns LJ, Sklar C, Forman S, Weisdorf D, Gurney JG, Bhatia S
      Diabetes, hypertension, and cardiovascular events in survivors of hematopoietic cell transplantation: a report from the bone marrow transplantation survivor study.
      17047152 Blood, 2007 Feb 15 : 1765-72
    • Fraser CJ, Bhatia S, Ness K, Carter A, Francisco L, Arora M, Parker P, Forman S, Weisdorf D, Gurney JG, Baker KS
      Impact of chronic graft-versus-host disease on the health status of hematopoietic cell transplantation survivors: a report from the Bone Marrow Transplant Survivor Study.
      16788100 Blood, 2006 Oct 15 : 2867-73
    • Gurney JG, Ness KK, Sibley SD, O'Leary M, Dengel DR, Lee JM, Youngren NM, Glasser SP, Baker KS
      Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemia.
      16894525 Cancer, 2006 Sep 15 : 1303-12
    • Kharbanda S, Panoskaltsis-Mortari A, Haddad IY, Blazar BR, Orchard PJ, Cornfield DN, Grewal SS, Peters C, Regelmann WE, Milla CE, Baker KS
      Inflammatory cytokines and the development of pulmonary complications after allogeneic hematopoietic cell transplantation in patients with inherited metabolic storage disorders.
      16545727 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2006 April : 430-7
    • Gurney JG, Ness KK, Rosenthal J, Forman SJ, Bhatia S, Baker KS
      Visual, auditory, sensory, and motor impairments in long-term survivors of hematopoietic stem cell transplantation performed in childhood: results from the Bone Marrow Transplant Survivor study.
      16453335 Cancer, 2006 Mar 15 : 1402-8
    • Petryk A, Bergemann TL, Polga KM, Ulrich KJ, Raatz SK, Brown DM, Robison LL, Baker KS
      Prospective study of changes in bone mineral density and turnover in children after hematopoietic cell transplantation.
      16352681 The Journal of clinical endocrinology and metabolism, 2006 March : 899-905
    • Fraser CJ, Hirsch BA, Dayton V, Creer MH, Neglia JP, Wagner JE, Baker KS
      First report of donor cell-derived acute leukemia as a complication of umbilical cord blood transplantation.
      16118319 Blood, 2005 Dec 15 : 4377-80
    • Baker KS, Loberiza FR Jr, Yu H, Cairo MS, Bolwell BJ, Bujan-Boza WA, Camitta BM, Garcia JJ, Ho WG, Liesveld JL, Maharaj D, Marks DI, Schultz KR, Wiernik P, Zander AR, Horowitz MM, Keating A, Weisdorf DJ
      Outcome of ethnic minorities with acute or chronic leukemia treated with hematopoietic stem-cell transplantation in the United States.
      16145067 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005 Oct 1 : 7032-42
    • Ness KK, Bhatia S, Baker KS, Francisco L, Carter A, Forman SJ, Robison LL, Rosenthal J, Gurney JG
      Performance limitations and participation restrictions among childhood cancer survivors treated with hematopoietic stem cell transplantation: the bone marrow transplant survivor study.
      16061776 Archives of pediatrics & adolescent medicine, 2005 Aug. : 706-13
    • Punyko JA, Mertens AC, Gurney JG, Yasui Y, Donaldson SS, Rodeberg DA, Raney RB, Stovall M, Sklar CA, Robison LL, Baker KS
      Long-term medical effects of childhood and adolescent rhabdomyosarcoma: a report from the childhood cancer survivor study.
      15700252 Pediatric blood & cancer, 2005 Jun 15 : 643-53
    • Peters A, Manivel JC, Dolan M, Gulbahce HE, Baker KS, Verneris MR
      Pulmonary cytolytic thrombi after allogeneic hematopoietic cell transplantation: a further histologic description.
      15931637 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2005 June : 484-5
    • Bhatia S, Robison LL, Francisco L, Carter A, Liu Y, Grant M, Baker KS, Fung H, Gurney JG, McGlave PB, Nademanee A, Ramsay NK, Stein A, Weisdorf DJ, Forman SJ
      Late mortality in survivors of autologous hematopoietic-cell transplantation: report from the Bone Marrow Transplant Survivor Study.
      15701723 Blood, 2005 Jun 1 : 4215-22
    • Punyko JA, Mertens AC, Baker KS, Ness KK, Robison LL, Gurney JG
      Long-term survival probabilities for childhood rhabdomyosarcoma. A population-based evaluation.
      15712283 Cancer, 2005 Apr 1 : 1475-83
    • Ness KK, Oakes JM, Punyko JA, Baker KS, Gurney JG
      Prevalence of the metabolic syndrome in relation to self-reported cancer history.
      15723765 Annals of epidemiology, 2005 March : 202-6
    • Kumar A, Saltzman D, Shukula M, Lewis V, Wendorf R, Sauer M, Neglia J, Baker KS, Macmillan M, Steiner ME
      Diagnostic peritoneal lavage for assessing acute abdomen in pediatric oncology and stem cell transplantation patients.
      15591904 Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology, 2004 Dec. : 824-6
    • Baker KS, Gurney JG, Ness KK, Bhatia R, Forman SJ, Francisco L, McGlave PB, Robison LL, Snyder DS, Weisdorf DJ, Bhatia S
      Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation: results from the Bone Marrow Transplant Survivor Study.
      15172972 Blood, 2004 Sep 15 : 1898-906
    • Barnett SJ, Weisdorf-Schindle S, Baker KS, Saltzman DA
      Spontaneous liver rupture in a child with graft-versus-host disease.
      15359415 Journal of pediatric surgery, 2004 Sept. : e1-3
    • Gulbahce HE, Pambuccian SE, Jessurun J, Woodard P, Steiner ME, Manivel JC, Hite S, Ramsay NK, Baker KS
      Pulmonary nodular lesions in bone marrow transplant recipients: impact of histologic diagnosis on patient management and prognosis.
      14983933 American journal of clinical pathology, 2004 Feb. : 205-10
    • Serna DS, Lee SJ, Zhang MJ, Baker S, Eapen M, Horowitz MM, Klein JP, Rizzo JD, Loberiza FR Jr
      Trends in survival rates after allogeneic hematopoietic stem-cell transplantation for acute and chronic leukemia by ethnicity in the United States and Canada.
      14551294 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003 Oct 15 : 3754-60
    • Gulbahce HE, Baker KS, Kumar P, Kjeldahl K, Pambuccian SE
      Atypical cells in bronchoalveolar lavage specimens from bone marrow transplant recipients. A potential pitfall.
      12866379 American journal of clinical pathology, 2003 July : 101-6
    • Baker KS, DeFor TE, Burns LJ, Ramsay NK, Neglia JP, Robison LL
      New malignancies after blood or marrow stem-cell transplantation in children and adults: incidence and risk factors.
      12663726 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003 Apr 1 : 1352-8
    • Breneman JC, Lyden E, Pappo AS, Link MP, Anderson JR, Parham DM, Qualman SJ, Wharam MD, Donaldson SS, Maurer HM, Meyer WH, Baker KS, Paidas CN, Crist WM
      Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma--a report from the Intergroup Rhabdomyosarcoma Study IV.
      12506174 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003 Jan 1 : 78-84
    • Baker KS, Anderson JR, Lobe TE, Wharam MD, Qualman SJ, Raney RB, Ruymann FB, Womer RB, Meyer WH, Link MP, Crist WM
      Children from ethnic minorities have benefited equally as other children from contemporary therapy for rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Study Group.
      12431964 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002 Nov 15 : 4428-33
    • Bridge JA, Liu J, Qualman SJ, Suijkerbuijk R, Wenger G, Zhang J, Wan X, Baker KS, Sorensen P, Barr FG
      Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes.
      11807989 Genes, chromosomes & cancer, 2002 March : 310-21
    • Baker KS, Wagner JE
      Novel conditioning regimens and nonmyeloablative stem cell transplants.
      11880729 Current opinion in pediatrics, 2002 Feb. : 17-22

  • Presentations

    Presentation Title Event Location Date
    Cancer Survivorship and Implementing Care Plans Montana Cancer Control Coalition Helena, MT Nov 5, 2009
    Models of Survivorship Care 1st Annual Survivorship Symposium: Cancer Survivorship and Health Disparities George Washington Cancer Institute - Washington, DC Oct 15, 2009
    Special Considerations and Complications Related to Long-Term Outcomes in Infants after HCT American Society Blood and Marrow Transplant San Diego, CA Feb 12, 2009

  • Research Funding

    Grant Title Grantor Amount Award Date
    Abdominal aorta intima-media thickness: a measure of early subclinical atherosclerosis Minnesota Medical Foundation $12,000.00 Aug 15, 2008
    Gene Therapy for Purine Nucleoside Phosphorylase Deficiency (PNP) NIAID $75,000.00 May 1, 2007
    Metabolic Syndrome Following Transplant for Leukemia NIH/NCI $1,497,680.00 Aug 15, 2006
    Metabolic Syndrome in Childhood Cancer Survivors NIH/NCI $2,317,865.00 Apr 1, 2006
    FHCRC Survivorship Program Lance Armstrong Foundation $1,700,054.00 Jan 1, 2006
    Pediatric Cancer Epidemiology Training Grant National Institutes of Health $1,115,934.00 Sep 30, 2004

Overview

Board Certification(s)

Pediatric Hematology-Oncology

Medical/Professional School

University of Nebraska College of Medicine, Omaha, NE

Clinical Interests

Hematopoietic cell transplantation for non-malignant hematologic diseases
Immune deficiencies
Histiocytic disorders
Cord blood transplantation
Long-term complications of cancer therapy
Etiology and risk factors for late effects in survivors after hematopoietic cell transplantation
Metabolic syndrome
Cardiovascular risk in cancer survivors

Research Focus Area

Translational Research