Wayne Leslie Chandler, MD

Wayne Leslie Chandler, MD

Laboratory Medicine

On staff since March 2015

Children's Title: Division Chief, Clinical Pathology

  • Wayne L. Chandler, MD is currently Division Chief for Laboratory Medicine, Department of Laboratories at Seattle Childrens hospital.

    Previously he was a Professor of Pathology and Laboratory Medicine at the Weill Cornell Medical College of Cornell University and worked in the Department of Pathology and Genomic Medicine at the Methodist Hospital in Houston, Texas. Prior to that he was a Professor of Laboratory Medicine at the University of Washington working at UWMC and Harborview Medical Center. He received his undergraduate degree from the University of Utah, his medical degree from St. Louis University School of Medicine, and completed a residency in Clinical Pathology at the University of Washington. His clinical practice and research focuses on diagnostic testing for hemostatic and thrombotic disorders.

  • Manuscripts in Refereed Journals

    • Aldea GS, Soltow LO, Chandler WL, Triggs CM, Vocelka CR, Crockett GI, Shin YT, Curtis WE, Verrier ED
      Limitation of thrombin generation, platelet activation, and inflammation by elimination of cardiotomy suction in patients undergoing coronary artery bypass grafting treated with heparin-bonded circuits.
      11986603 The Journal of thoracic and cardiovascular surgery, 2002 April : 123(4)742-55

    Other Publications

    • Chandler WL
      Measurement of microvesicle levels in human blood using flow cytometry.
      26606416 Cytometry. Part B, Clinical cytometry, 2015 Nov. 25
    • Thompson-Moore NR, Wanat MA, Putney DR, Liebl PH, Chandler WL, Muntz JE
      Evaluation and Pharmacokinetics of Treatment Dose Enoxaparin in Hospitalized Patients With Morbid Obesity.
      25601898 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2015 Jan. 19
    • Chandler WL, Dawson KL, Ruegger MC, Teruya M, Liebl PH, Monsour HP
      Patients with cirrhosis show a relative increase in thrombin generation that is correlated with lower antithrombin levels.
      25402190 Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2014 Nov. 14
    • Shu I, Wright AM, Chandler WL, Bernard DW, Wang P
      Analytical performance of QMS everolimus assay on ortho Vitros 5,1 FS fusion analyzer: measuring everolimus trough levels for solid organ transplant recipients.
      24232125 Therapeutic drug monitoring, 2014 April : 36(2)264-8
    • Wanat MA, Hart SR, Putney D, Liebl MG, Chandler W
      Alternative monitoring of argatroban using plasma-diluted thrombin time.
      23482736 The Annals of pharmacotherapy, 2013 April : 47(4)e18
    • Avecilla ST, Ferrell C, Chandler WL, Reyes M
      Plasma-diluted thrombin time to measure dabigatran concentrations during dabigatran etexilate therapy.
      22431533 American journal of clinical pathology, 2012 April : 137(4)572-4
    • Bohling SD, Pagano MB, Stitzel MR, Ferrell C, Yeung W, Chandler WL
      comparison of clot-based vs chromogenic factor Xa procoagulant phospholipid activity assays.
      22261442 American journal of clinical pathology, 2012 Feb. : 137(2)185-92
    • Sniecinski RM, Chandler WL
      Activation of the hemostatic system during cardiopulmonary bypass.
      22003219 Anesthesia and analgesia, 2011 Dec. : 113(6)1319-33
    • Chandler WL, Ferrell C, Trimble S, Moody S
      Development of a rapid emergency hemorrhage panel.
      20573070 Transfusion, 2010 Dec. : 50(12)2547-52
    • Dunbar NM, Chandler WL
      Thrombin generation in trauma patients.
      19682336 Transfusion, 2009 Dec. : 49(12)2652-60
    • Baird GS, Rainey PM, Wener M, Chandler W
      Reducing routine ionized calcium measurement.
      19168556 Clinical chemistry, 2009 March : 55(3)533-40
    • Eisses MJ, Richards M, Joffe D, Geiduschek JM, Chandler WL
      The Response of Hemostatic Marker Levels to Activated Factor VII in a Neonate following Cardiopulmonary Bypass.
      19730751 Case reports in medicine, 2009 : 2009420152 PMCID:PMC2735071
    • Olson JD, Brandt JT, Chandler WL, Van Cott EM, Cunningham MT, Hayes TE, Kottke-Marchant KK, Makar RS, Uy AB, Wang EC
      Laboratory reporting of the international normalized ratio: progress and problems.
      17979481 Archives of pathology & laboratory medicine, 2007 Nov. : 131(11)1641-7
    • Takayama H, Soltow LO, Chandler WL, Vocelka CR, Aldea GS
      Does the type of surgery effect systemic response following cardiopulmonary bypass?
      17661772 Journal of cardiac surgery, 2007 July : 22(4)307-13
    • Eisses MJ, Geiduschek JM, Jonmarker C, Cohen GA, Chandler WL
      Effect of polymer coating (poly 2-methoxyethylacrylate) of the oxygenator on hemostatic markers during cardiopulmonary bypass in children.
      17289476 Journal of cardiothoracic and vascular anesthesia, 2007 Feb. : 28-34
    • Rinder CS, Rinder HM, Smith MJ, Fitch JC, Tracey JB, Chandler WL, Rollins SA, Smith BR
      Antithrombin reduces monocyte and neutrophil CD11b up regulation in addition to blocking platelet activation during extracorporeal circulation.
      16836559 Transfusion, 2006 July : 46(7)1130-7
    • Doherty MJ, Watson NF, Hallam DK, Chandler WL, Longstreth WT Jr
      Ventricular cerebrospinal fluid hypocretin-1 inversely correlates with glucose levels in cerebrospinal fluid and serum from patients with neurological injuries.
      16377834 Neurocritical care, 2005 : 3(3)230-3
    • Chandler WL, Velan T
      Plasmin generation and D-dimer formation during cardiopulmonary bypass.
      15389126 Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2004 Oct. : 15(7)583-91
    • Fras Z, Keber D, Chandler WL
      The effect of submaximal exercise on fibrinolysis.
      15060418 Blood coagulation and fibrinolysis : an international journal in haemostasis and thrombosis, 2004 April : 15(3)227-34
    • Poliachik SL, Chandler WL, Ollos RJ, Bailey MR, Crum LA
      The relation between cavitation and platelet aggregation during exposure to high-intensity focused ultrasound.
      14998678 Ultrasound in medicine & biology, 2004 Feb. : 30(2)261-9
    • Velan T, Chandler WL
      Effects of surgical trauma and cardiopulmonary bypass on active thrombin concentrations and the rate of thrombin inhibition in vivo.
      15170395 Pathophysiology of haemostasis and thrombosis, 2003 May : 33(3)144-56
    • Morgan EN, Pohlman TH, Vocelka C, Farr A, Lindley G, Chandler W, Griscavage-Ennis JM, Verrier ED
      Nuclear factor kappaB mediates a procoagulant response in monocytes during extracorporeal circulation.
      12539000 The Journal of thoracic and cardiovascular surgery, 2003 Jan. : 125(1)165-71
    • Tarr PI, Tsai HM, Chandler WL
      Thrombotic microangiopathies.
      12501862 The New England journal of medicine, 2002 Dec. 26 : 347(26)2171-3; author reply 2171-3
    • Tarr PI, Gordon CA, Chandler WL
      Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome.
      15781103 Lancet, 365(9464)1073-86


Board Certification(s)

Pathology - Clinical

Medical/Professional School

St. Louis University, St. Louis


Pathology - Anatomic, University of Washington, Seattle

Clinical Interests

Laboratory medicine, hemostasis and thrombosis, clinical chemistry

Research Description

Regulation of hemostasis and thrombosis