Philip G. Morgan, MD

Anesthesia, Mitochondrial Medicine

On staff since June 2008

Academic Title: Professor in the Department of Anesthesiology and Pain Medicine, University of Washington

Research Center: Center for Integrative Brain Research

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  • Awards and Honors

    Award Name Award Description Awarded By Award Date
    Best Research Poster United Mitochondrial Disease Foundation (UMDF) Conference 2017
    Best of Science Abstract ASA 2016
    E I "Ted" Eger Lecture Western Anesthesia Residents Conference, Seattle, WA March 2015
    Best Abstract United Mitochondrial Disease Foundation July 2014
    Best Abstracts, 2012 ASA 2012
    Best Abstracts 2011 ASA Meeting 2011

  • Publications

    Manuscripts in Refereed Journals

    • Carspecken CW, Chanprasert S, Kalume F, Sedensky MM, Morgan PG
      Anesthetics have different effects on the electrocorticographic spectra of wildtype and mitochondrial mutant mice
      Anesth , 2018 : 129(4)744-755
    • Zimin PI, Woods CB, Kayser EB, Ramirez J-N, Morgan PG, Sedensky MM
      Isoflurane disrupts excitatory neurotransmitter dynamics via inhibition of mitochondrial complex I
      Br J Anaesth, 2018 : 120(5)1019-1032
    • Steele LM, Morgan PG
      General Genetic Strategies
      Methods Enzymol , 2018 : 602113-132
    • Bennett CF, Kwon JJ, Chen C, Russell J, Acosta K, Burnaevskiy N, Crane MM, Bitto A, Vander Wende H, Simko M, Pineda V, Rossner R, Wasko BM, Choi H, Chen S, Park S, Jafari G, Sands B, Perez Olsen C, Mendenhall AR, Morgan PG, Kaeberlein M.
      Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans
      PLoS Genet, 2017 : 13(3)e1006695
    • van der Bliek AM, Sedensky MM, Morgan PG
      Cell Biology of the Mitochondrion
      Genetics, 2017 : 207(3)843-871
    • Ramadasan-Nair R, Hui J, Zimin PI, Itsara LS, Morgan PG, Sedensky MM
      Regional knockdown of NDUFS4 implicates a thalamocortical circuit mediating anesthetic sensitivity
      PLoS One , 2017 : 12(11)e0188087
    • Hyo-Seok Na, Brockway NL, Gentry KR, Opheim E, Sedensky MM, Morgan PG
      The Genetics of Isoflurane-induced Developmental Neurotoxicity
      PMC5367966 Neurotox Teratol, 2017 : 6040-49
    • Hsieh VC, Krane EJ, Morgan PG
      Mitochondrial disease and anesthesia
      J Inb Err Metab & Screen, 2017 : 51-5
    • Kayser EB, Sedensky MM, Morgan PG
      Region-Specific Defects of Respiratory Capacities in the Ndufs4(KO) Mouse Brain
      PMC4732614 PLoS One, 2016 Jan. 29 : 11((1))e0148219
    • Morgan PG, Sedensky MM, Kayser EB
      Ketamine and mitochondrial function
      Anesth Analg, 2016 : 122917-18
    • Dancy BM, Brockway N, Ramadasan-Nair R, Yang Y, Sedensky MM, Morgan PG
      Glutathione S-transferase mediates an ageing response to mitochondrial dysfunction
      Mech Ageing Dev, 2016 Jan. : 15314-21
    • Zimin PI, Woods CB, Quintana A, Ramirez JM, Morgan PG, Sedensky MM
      Glutamatergic neurotransmission links sensitivity to volatile anesthetics with mitochondrial function
      PMC5007115 Curr Biol, 2016 : 26((16))2194-201
    • Higdon R, Kolker N, Bauman AT, Ilkayeva O, Newgard CB, Kolker E, Steele LM, Sedensky MM
      Comparison of proteomic and metabolomic profiles of mutants of the mitochondrial respiratory chain in Caenorhabditis elegans
      Mitochondrion, 2015 : 2095-102
    • Dancy BM, Sedensky MM
      Mitochondrial bioenergetics and disease in Caenorhabditis elegans
      Front Biosci, 2015 : 20198-228
    • D’Almeida RE, Alberto MR, Sedensky MM, Isla MI
      Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans
      Acta Parasitologica, 2015 : 60164-172
    • Kajimoto M, Atkinson DB, Ledee DR, Kayser, EB, Morgan PG, Sedensky MM, Isern NG, Des Rosiers C, Portman MA
      Propofol compared to isoflurane inhibits mitochondrial metabolism in immature swine cerebral cortex
      J Cereb Blood Flow Metab, 2014 : 34(3)514-21
    • Philip G. Morgan, MD, Sedensky, M., Suthammarak, W., Opheim, E., Somerlot, B
      Novel Interactions between Mitochondrial Superoxide Dismutases and the Electron Transport Chain
      Aging Cell, 2013 : 12(6)239-50
    • Philip G. Morgan, MD, Gentry, K., Steele, L. M., Sedensky, M
      Early developmental exposure to volatile anesthetics causes behavioral defects in C. elegans
      Anesthesia and Analgesia, 2013 : 116185-189
    • Johnson SC, Yanos ME, Kayser EB, Quintana A, Sangesland M, Castanza A, Uhde L, Hui J, Wall VZ, Gagnidze A, Oh K, Wasko B, Ramos FJ, Palmiter R, Rabinovitch P, Morgan PG, Sedensky MM, Kaeberlein M
      mTOR Inhibition by Rapamycin Alleviates Mitochondrial Disease 1! in the Ndufs4 -/- Mouse Model of Leigh Syndrome
      Science, 2013 : epub ahead
    • Morgan, P., Quintana, A., Kruse, S. E., Palmiter, R. D., Sedensky, M.
      Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I
      PLoS One, 7e42904
    • Philip G. Morgan, MD, Niezgoda, J
      Anesthetic considerations in patients with mitochondrial defects
      Pediatric Anesthesia, 23785-793
    • Philip G. Morgan, MD, Sedensky, M., Williams, M. A
      Mitochondrial DNA copy number and oxidative DNA damage in placental tissues from gestational diabetes and control pregnancies: A Pilot Study
      Clinicial Laboratory, 59655-60

    Book Chapters

    • Hsieh V, Morgan PG
      Myopathies of the Newborn
      Essentials of Anesthesia for Infants and Neonates, eds. Mary Ellen McCann, Kai Matthes & Christine Greco, Cambridge University Press, 2018
    • Morgan PG, Sedensky MM
      Respiratory Disease and Anesthetic Considerations
      Clinical Mitochondrial Medicine. Eds. Patrick F Chinnery, Michael J Keogh, Cambridge University Press, 2018
    • Sedensky MM, Morgan PG
      Using Caenorhabditis elegans to study neurotoxicity
      Handbook of Develop Neurotox, eds. Slikker W, Paule MG, Wang C, Academic Press, 2017 : 153-162

    Manuscripts Submitted

    • Hyo-Seok Na, Brockway NL, Gentry KR, Opheim E, Sedensky MM, Morgan PG
      The Genetics of Isoflurane-induced Developmental Neurotoxicity
      Neurotox Teratol, 2016 : In press
    • Morgan, P., Gentry, K. R., Steele, L. M., Sedensky, M.
      Early developmental exposure to volatile anesthetics causes behavioral defects in C. elegans
      Anesthesia and Analgesia

    Published Abstracts

    • Carspeken CW, Sedensky MM, Kalume F, Morgan PG
      Ketamine resistance in mic with neuronal type specific KO of a mitochondrial protein
      AUA abstract TRSL/BS , 2017 : 691402
    • Ramadasan-Nair R, Hui J, Morgan PG, Sedensky MM
      Astrocyte Specific knockout of a mitochondria protein in mice increases neural intertia
      AUA abstract NR , 2017 : 461735
    • Ramadasan-Nair R, Hui J, Morgan PG, Sedensky MM
      Astrocyte Specific knockout of a mitochondria protein in mice increases neural intertia
      AUA abstract NR 46(1735), 2017
    • Carspeken CW, Sedensky MM, Kalume F, Morgan PG
      Ketamine resistance in mic with neuronal type specific KO of a mitochondrial protein
      AUA abstract TRSL/BS 69 (1402), 2017
    • 4. Na H-S, Brockway NL, Opheim E, Sedensky MM, Morgan PG
      Genetics of Isoflurane induced Neurotoxicity in C. elegans
      Abstract #1278; IARS Meeting. San Francisco, 2016 May 21
    • Na H-S, Brockway NL, Opheim E, Sedensky MM, Morgan PG
      Genetics of Isoflurane induced Neurotoxicity
      Abstract #121; AUA Meeting. San Francisco, 2016 May 20
    • Zimin PI, Woods CB, Ramirez JM, Morgan PG, Sedensky MM
      Isoflurane inhibits excitatory neurotransmission in the anesthetic hypersensitive mouse mutant, Ndufs4(KO).
      AUA Meeting. Abstract #149; San Francisco, 2016 May 19
    • Na H-S, Brockway NL, Opheim E, Sedensky MM, Morgan PG
      Genetics of Isoflurane induced Neurotoxicity
      Abstract #121; SPA Meeting. Colorado Springs, 2016 April 2
    • Ramadasan-Nair R, Hui J , Itsara J, Morgan PG, Sedensky, MM
      Effects of region-specific knock out of Ndufs4 on Volatile Anesthetic Response
      ASA meeting: Abstract # BOS05, 2016
    • Ramadasan-Nair R, Hui J, Morgan PG, Sedensky, MM
      Effects of Astrocytic Knock Out of the Mitochondrial Protein, NDUFS4, on Volatile Anesthetic Response
      ASA meeting: Abstract # A1153, 2016
    • Chanprasert S, Morgan PG, Sedensky, MM
      Anesthetics Have Differential Effects on the Spectral EEGs of Wildtype and Mitochondrial Mutant Mice
      ASA meeting: Abstract # A4018, 2016
    • Zimin PI; Woods CB, Ramirez JM, Morgan PG; Sedensky MM
      Isoflurane Inhibits Excitatory Neurotransmission in the Anesthetic Hypersensitive Mouse Mutant, Ndufs4(KO).
      ASA meeting: Abstract # A1156, 2016
    • Dancy B, Sedensky MM
      A maladaptive glutathione S-transferase in mitochondrial dysfunction
      UMDF, 2014
    • Kayser EB, Sedensky MM
      Brain regions prone to neurodegeneration in the Ndufs4 KO mouse yield synaptosomes with low capacity to respire
      UMDF, 2014
    • Jung S, Sedensky MM
      Molecular mechanisms of ketamine resistance in Ndufs4-KO mice
      ASA meeting, 2014
    • Gentry KR, Na H-S, Brockway NL, Sedensky MM
      Inhibition of isoflurane-induced neurotoxicity
      ASA meeting, 2014
    • Sedensky MM, Kayser EB, Morgan PG
      Region specific differences in oxidative phosphorylation in mitochondria from Ndufs4 knockout mice
      2013
    • Kayser EB, Sedensky MM, Morgan PG
      Capacity for oxidative phosphorylation does not decline with age in mitochondria from Ndufs4 knockout mice
      2013
    • Sedensky MM, Morgan PG
      Excitatory Synaptic Transmission is Depressed in a Mutant Mouse With Anesthetic Hypersensitivity
      2013
    • Morgan PG, Kayser EB, Sedensky MM
      Capacity for oxidative phosphorylation does not decline with age in mitochondria from Ndufs4 knockout mice
      2013
    • Morgan PG, Kayser EB, Sedensky MM
      Region specific differences in oxidative phosphorylation in mitochondria from Ndufs4 knockout mice
      2013
    • Sedensky MM, Morgan PG
      Glutamatergic Cell-Specific Mutations in Complex I Control Volatile Anesthetic Sensitivity
      2013

    Other Publications

    • Hsieh V, Morgan PG
      Myopathies of the Newborn
      Essentials of Anesthesia for Infants and Neonates, eds. Mary Ellen McCann, Kai Matthes and Christine Greco, Cambridge University Press, 2016
    • Hsieh V
      Muscle Disorders
      Smith’s Anesthesia for Infants and Children, ed. Peter Davis, Mosby, 2015
    • Eckenhoff RG
      Forward to the Past. Editorial
      Anesth Analg, 2015 : 120259-60
    • 2. Parikh S, Goldstein A, Koenig MK, Scaglia F, Enns GM, Saneto R, Anselm I, Cohen BH, Falk MJ, Greene C, Gropman AL, Haas R, Hirano M, Sims K, Tarnopolsky M, Van Hove JL, Wolfe L, DiMauro S
      Diagnosis and management of mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society
      doi: 10.1038/gim.2014.177 Genet Med, 2014 Dec. 11 : [Epub ahea
    • Sedensky MM, Morgan PG
      Genetics and the evolution of the anesthetic response.
      18713894 Anesthesia and analgesia, 2008 Sept. : 855-8
    • Falk MJ, Kayser EB, Morgan PG, Sedensky MM
      Mitochondrial complex I function modulates volatile anesthetic sensitivity in C. elegans.
      16920626 Current biology : CB, 2006 Aug. 22 : 1641-5
    • Sedensky MM, Morgan PG
      Mitochondrial respiration and reactive oxygen species in mitochondrial aging mutants.
      16497463 Experimental gerontology, 2006 March : 237-45
    • Morgan, P., Singaram, V. K., Sedensky, M.
      Anesthetic Mechanisms: The worm sheds light on anesthetic mechanisms
      Worm, 1(3)1-6
    • Karamanlidis, G., Tian, R., Sedensky, M., Kolwicz, S., Wang, W., Suthammarak, W., Lee, C. F., Garcia-Menendez, L., Gong, G
      Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure
      Cell Metabolism, 18239-250
    • Morgan, P., Qui, C., Havner, K., Abetew, D., Sedensky, M., Enquobahrie, D. A., Williams, M. A.
      Mitochondrial DNA copy number and oxidative DNA damage in placental tissues from gestational diabetes and control pregnancies: A Pilot Study
      Clinicial Laboratory

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  • Presentations

    Presentations Title Event Location Date
    Clinical Significance of Mouse Anesthesia Induced Neurotoxicity Experimental Paradigms 4th PANDA Symposium on Anesthetic Neurotoxicity Columbia University New York, NY April 13, 2018
    Mitochondrial Effects on Anesthetic Sensitivity and Anesthetic Induced Neurotoxicity Bioenergetics Subcommittee Biophysical Society Platform Talk San Francisco, CA Feb. 17, 2018
    Mitochondria, Anesthetics and the Glutamatergic Synapse ASA Meeting, 2017 Panel Talk Boston, MA Oct. 21, 2017
    Pediatric Anesthetic Neurotoxicity: an Update New Mexico Society of Anesthesiologists Annual Meeting Albuquerque, NM Feb. 25, 2017
    Effects of region-specific knock out of Ndufs4 on Volatile Anesthetic Response Best of Science Abstract, ASA meeting Oct. 22, 2016
    Mitochondrial Disease and Anesthesia Stanford University, Department of Anesthesiology and Perioperative Medicine, Grand Rounds Oct. 10, 2016
    The roles of mTOR and ER-stress in isoflurane induced neurotoxicity International Conference on Neuroprotective Agents Biobao, Spain Sept. 20, 2016
    The Genetics of Isoflurane induced Neurotoxicity in C. elegans. 3rd PANDA Symposium on Anesthetic Neurotoxicity , Columbia University New York, NY April 16, 2016
    Anesthetic Sensitivity and Mitochondria 9th International Conference on Anesthetic Mechanisms Bonn, Germany June 18, 2015
    Anesthetics and Mitochondria University of Washington, Mitochondrial Interest Group Seattle, WA May 1, 2015
    Anesthetic Effects on Mitochondria University of Pennsylvania, Dept. Anesthesiology, Research in Progress Philadelphia, PA April 15, 2015
    The role of mitochondrial dysfunction in aging and anesthetic behavior Pathology Presents Symposium Series, University of Washington Seattle, WA Nov. 19, 2014
    The interactions of anesthetics and perioperative medications with mitochondrial disease. United Mitochondrial Disease Foundation Newport Beach, CA June 11, 2013
    Anesthetic care of patients with myotonia vs. mitochondrial disease International Anesthesia Research Society San Diego, CA May 5, 2013

  • Research Funding

    Grant Title Grantor Amount Award Date
    A mouse model linking anesthetic sensitivity to mitochondrial function National Institute of Health Grant 2018 - 2022
    Isoflurane Inhibition of Synaptic Endocytosis National Institute of Health Grant 2018 - 2022
    Anesthetic neurotoxicity is controlled by ER stress. National Institute of Health Grant 2017 - 2021
    A mouse model linking mitochondrial function to anesthetic sensitivity. National Institute of Health Grant 2014 - 2018

Overview

Board Certification(s)

Anesthesiology

Medical/Professional School

University of Colorado School of Medicine, Aurora
University of Colorado at Boulder, Boulder

Residency

Anesthesiology, University Hospitals of Cleveland Attn: Faculty Affairs, Cleveland

Fellowship

Pediatrics, University Hospitals of Cleveland Attn: Faculty Affairs, Cleveland
Anesthesiology, University of Washington, Seattle
Anesthesiology, University of Washington, Seattle

Research Description

We study the effects of genetic changes on mitochondrial function. Our primary work is in the nematode C. elegans. However, we are extending our studies to the effects of anesthetics on mitochondrial function in humans. We are also studying the mechanism of action of volatile anesthetics. These studies also focus on the genetic control of anesthetic sensitivity using the nematode C. elegans.

About My Work

https://www.seattlechildrens.org/research/integrative-brain-research/our-labs/morgan-laboratory/

Research Focus Area

Pharmacology, Neuroscience / Neurodevelopment, Genetics and Developmental Biology, Mitochondrial disease