Kevin B. Urdahl, MD, PhD

Kevin B. Urdahl, MD, PhD

Infectious Disease, Infectious Disease Research

Children's Title: Professor

Academic Title: Affiliate Professor, University of Washington

Research Center: Center for Global Infectious Disease Research

  • Award Name Award Description Awarded By Award Date
    Member, Society for Pediatric Research 2009
    Research Royalty Fund Pilot Award University of Washington 2007
    Puget Sound Partners in Global Health Pilot Project Award 2006
    Burroughs Wellcome Career Award in the Biological Sciences 2003
    Child Health Research Center Scholar 2003
    Pediatric Immunology Training Grant Fellowship 2002
    Pediatric Scientist Development Program Fellowship 1999
    Bacaner Graduate Medical Research Award, Microbiology (annual award to top Ph.D. graduate) 1993
    J. Thomas Livermore Award, Medical Student Research Award, Hematology 1992
    Graduate School Dissertation Fellowship University of Minnesota 1992
    N.I.H. Immunology Training Grant Fellowship 1991
  • Presentations Title Event Location Date
    TGFß restricts T cell-mediated immunity in the TB granuloma InterCenter Discovery Lunch Seattle Children's Research Institute, Seattle WA 2019
    T cell mediated immunity in the tuberculous granuloma Cambridge Immunology Network Seminar MRC Laboratory of Molecular Biology, University of Cambridge 2017
    Basic Immunology and Developing an Effective TB Vaccine 3rd Annual Collaboration for TB Vaccine Discovery Meeting Bill and Melinda Gates Foundation, Seattle WA 2017
    Of Mice and Men: Tuberculosis Fiction or a Model of Human Disease? Microbiology and Immunobiology Seminar Harvard University 2017
    Of Mice and Men: Tuberculosis Fiction or a Model of Human Disease? Microbiology and Immunology Seminar University of California, Berkeley 2017
    Of Mice and Men: Tuberculosis Fiction or a Model of Human Disease? Microbiology and Immunology Seminar Albert Einstein College of Medicine, Bronx NY 2016
    Of Mice and Men: Tuberculosis Fiction or a Model of Human Disease? Division of Immunology and Pathogenesis, University of California, Berkeley 2016
    Of Mice and Men: Tuberculosis Fiction or a Model of Human Disease? Microbiology and Immunology Seminar Albert Einstein College of Medicine, Bronx NY 2016
    Update on our understanding of conventional T cells and immunity against TB 2nd Annual Collaboration for TB Vaccine Discovery Meeting Bill and Melinda Gates Foundation, Seattle WA 2016
    Mucosal immunity to bacterial pathogens Block Symposium, 103st Annual Meeting American Association of Immunologists, Seattle WA 2016
    The complex relationship between effector T cell specificity, localization, and function during pulmonary tuberculosis Copenhagen, Denmark 2015
    Understanding and overcoming the barriers to T cell mediated immunity against tuberculosis Seminar Series University of Iowa, Iowa City IA 2015
    Understanding and overcoming the barriers to T cell mediated immunity against tuberculosis Seminar Series Seattle Biomedical Research Institute, Seattle WA 2014
    Regulatory T cells in tuberculosis Seminar Series University of Iowa, Iowa City IA 2014
    The complex relationship between effector T cell specificity, location, and function during pulmonary TB Seminar Series Trudeau Institute, Saranac Lake NY 2014
    Immunology of the Airway Block Symposium, 101st Annual Meeting American Association of Immunologists, Pittsburgh PA 2014
  • Grant Title Grantor Amount Award Date
    Characterization of Recent Thymic Emigrants - R01AI064318 (PI: Urdahl) NIH/NIAID $470,750/year March 2019 - Feb. 2020
    TOLLIP Deficiency, Immune Dysregulation, and Tuberculosis Susceptibility - 1R01AI136921-01 (PI: Shah) Role: Co-Investigator NIH/NIAID $50,000/year March 2018 - Feb. 2023
    Omics for TB: Response to Infection and Treatment - 1U19AI35976-01 (PI: Aderem/Sherman) Role: Co-Investigator NIH/NIAID $285,652/year Feb. 2018 - Jan. 2023
    A dual function TB subunit vaccine designed for non-interference with BCG and post-exposure activity - 1R01AI135721-01 (PI: Andersen) Role: Co-Investigator NIH/NIAID $15,355/year Dec. 2017 - Nov. 2022
    Eliciting lung-localized CD4 T cell responses against Mycobacterium tuberculosis - 1R01AI134246-01 (PI: Urdahl) NIH/NIAID $206,932/year Aug. 2017 - 2022
    HIV Integration-Mediated Modulation of Immune Regulation in HPV-Associated Cancers - 5R01CA206466-02 (PI: Frenkel) Role: Co-Investigator NIH/NCI $2007/year Sept. 2016 - Aug. 2021

Overview

Medical/Professional School

University of Minnesota, Minneapolis

Residency

Pediatrics, University of Washington, Seattle

Fellowship

Pediatric Infectious Disease, University of Washington, Seattle

Clinical Interests

Tuberculosis; Protective immunity against tuberculosis; Tuberculosis vaccines

Research Description

My laboratory is applying recently-developed immunologic tools to the study of tuberculosis in order to gain a better understanding of T lymphocyte-mediated mechanisms that promote protection against tuberculosis and also mechanisms that suppress immunity and help facilitate persistence of the pathogen. The overall goal of this research is to identify strategies that could contribute to the development of an effective vaccine. 

Recently, my laboratory defined a role for a suppressive subset of T lymphocytes that dampens immunity and prevents the immune system from effectively eradicating the bacteria that causes tuberculosis.

Research Focus Area

Host-Pathogen Interaction, Tuberculosis, Infectious Disease, Host: Pathogen Interaction