Kevin B. Urdahl, MD, PhD
Award Name Award Description Awarded By Award Date Member, Society for Pediatric Research 2009 Research Royalty Fund Pilot Award University of Washington 2007 Puget Sound Partners in Global Health Pilot Project Award 2006 Burroughs Wellcome Career Award in the Biological Sciences 2003 Child Health Research Center Scholar 2003 Pediatric Immunology Training Grant Fellowship 2002 Pediatric Scientist Development Program Fellowship 1999 Bacaner Graduate Medical Research Award, Microbiology (annual award to top Ph.D. graduate) 1993 J. Thomas Livermore Award, Medical Student Research Award, Hematology 1992 Graduate School Dissertation Fellowship University of Minnesota 1992 N.I.H. Immunology Training Grant Fellowship 1991
Presentations Title Event Location Date TGFß restricts T cell-mediated immunity in the TB granuloma InterCenter Discovery Lunch Seattle Children's Research Institute, Seattle WA 2019 T cell mediated immunity in the tuberculous granuloma Cambridge Immunology Network Seminar MRC Laboratory of Molecular Biology, University of Cambridge 2017 Basic Immunology and Developing an Effective TB Vaccine 3rd Annual Collaboration for TB Vaccine Discovery Meeting Bill and Melinda Gates Foundation, Seattle WA 2017 Of Mice and Men: Tuberculosis Fiction or a Model of Human Disease? Microbiology and Immunobiology Seminar Harvard University 2017 Of Mice and Men: Tuberculosis Fiction or a Model of Human Disease? Microbiology and Immunology Seminar University of California, Berkeley 2017 Of Mice and Men: Tuberculosis Fiction or a Model of Human Disease? Microbiology and Immunology Seminar Albert Einstein College of Medicine, Bronx NY 2016 Of Mice and Men: Tuberculosis Fiction or a Model of Human Disease? Division of Immunology and Pathogenesis, University of California, Berkeley 2016 Of Mice and Men: Tuberculosis Fiction or a Model of Human Disease? Microbiology and Immunology Seminar Albert Einstein College of Medicine, Bronx NY 2016 Update on our understanding of conventional T cells and immunity against TB 2nd Annual Collaboration for TB Vaccine Discovery Meeting Bill and Melinda Gates Foundation, Seattle WA 2016 Mucosal immunity to bacterial pathogens Block Symposium, 103st Annual Meeting American Association of Immunologists, Seattle WA 2016 The complex relationship between effector T cell specificity, localization, and function during pulmonary tuberculosis Copenhagen, Denmark 2015 Understanding and overcoming the barriers to T cell mediated immunity against tuberculosis Seminar Series University of Iowa, Iowa City IA 2015 Understanding and overcoming the barriers to T cell mediated immunity against tuberculosis Seminar Series Seattle Biomedical Research Institute, Seattle WA 2014 Regulatory T cells in tuberculosis Seminar Series University of Iowa, Iowa City IA 2014 The complex relationship between effector T cell specificity, location, and function during pulmonary TB Seminar Series Trudeau Institute, Saranac Lake NY 2014 Immunology of the Airway Block Symposium, 101st Annual Meeting American Association of Immunologists, Pittsburgh PA 2014
Grant Title Grantor Amount Award Date Characterization of Recent Thymic Emigrants - R01AI064318 (PI: Urdahl) NIH/NIAID $470,750/year March 2019 - Feb. 2020 TOLLIP Deficiency, Immune Dysregulation, and Tuberculosis Susceptibility - 1R01AI136921-01 (PI: Shah) Role: Co-Investigator NIH/NIAID $50,000/year March 2018 - Feb. 2023 Omics for TB: Response to Infection and Treatment - 1U19AI35976-01 (PI: Aderem/Sherman) Role: Co-Investigator NIH/NIAID $285,652/year Feb. 2018 - Jan. 2023 A dual function TB subunit vaccine designed for non-interference with BCG and post-exposure activity - 1R01AI135721-01 (PI: Andersen) Role: Co-Investigator NIH/NIAID $15,355/year Dec. 2017 - Nov. 2022 Eliciting lung-localized CD4 T cell responses against Mycobacterium tuberculosis - 1R01AI134246-01 (PI: Urdahl) NIH/NIAID $206,932/year Aug. 2017 - 2022 HIV Integration-Mediated Modulation of Immune Regulation in HPV-Associated Cancers - 5R01CA206466-02 (PI: Frenkel) Role: Co-Investigator NIH/NCI $2007/year Sept. 2016 - Aug. 2021
- Medical/Professional School
University of Minnesota, Minneapolis
Pediatrics, University of Washington, Seattle
Pediatric Infectious Disease, University of Washington, Seattle
- Clinical Interests
Tuberculosis; Protective immunity against tuberculosis; Tuberculosis vaccines
- Research Description
My laboratory is applying recently-developed immunologic tools to the study of tuberculosis in order to gain a better understanding of T lymphocyte-mediated mechanisms that promote protection against tuberculosis and also mechanisms that suppress immunity and help facilitate persistence of the pathogen. The overall goal of this research is to identify strategies that could contribute to the development of an effective vaccine.
Recently, my laboratory defined a role for a suppressive subset of T lymphocytes that dampens immunity and prevents the immune system from effectively eradicating the bacteria that causes tuberculosis.
- Research Focus Area
Host-Pathogen Interaction, Tuberculosis, Infectious Disease, Host: Pathogen Interaction