Giacomo Tampella, PhD
Research Center: Ben Towne Center for Childhood Cancer Research
Dr. Giacomo Tampella, is a post-doctoral researcher in the Ben Towne Center for Childhood Cancer Research. He is conducting research in the field of the Cancer Immunotherapy, Advanced Lymphocyte Engineering and therapy development.
PhD, Immunology, Science of Reproduction and Molecular Genetics, University of Brescia and University of Trieste
Clinical trials in patients with advanced B cell malignancies treated with CD19-specific CAR-modified T cells (CAR-T) have shown impressive antitumor efficacy. This has increased the focus towards the potential antigens present exclusively in a variety of common solid tumors and brain tumors such as glioma and meduloblastoma. Some of the most extensively studied targets in this tumors are the interleukin-13 receptor alpha 2 (IL13R2) and the ephrin type-A receptor 2 (EphA2). As a PhD-Fellow at Ben Towne Center for Childhood Cancer Research (BTCCCR) the first part of my project will concern the design and implementation of chimeric antigen receptors to effectively and safely target these molecules.
Tampella G, Kerns HM, Niu D, Singh S, Khim S, Bosch KA, Garrett ME, Moguche A, Evans E, Browning B, Jahan TA, Nacht M, Wolf-Yadlin A, Plebani A, Hamerman JA, Rawlings DJ, James RGThe Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages.
26026062 Journal of immunology (Baltimore, Md. : 1950), 2015 July 1 : 195(1)246-56 PMCID:PMC4475445