Barry M. Gumbiner, PhD

"I am fascinated by how the complex 3-dimensional architecture of tissues and organs arises from individual cells. This process, called morphogenesis, is important not only for the development of the embryo, but also for the maintenance, remodeling, repair and regeneration of fully formed tissues in children and adults. We study how adhesion proteins called cadherins control the assembly, organization and maintenance of tissues. Deficits in cadherin function lead to many disease states, including birth defects, cancer (especially tumor metastasis), and inflammation, and we are developing approaches to restore cadherin function as a way to try to alleviate these diseases."

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    Barry M. Gumbiner, PhD, is a scientist and principal investigator at Seattle Childrens Research Institute's Center for Developmental Biology and Regenerative Medicine. He joined the research institute in 2015 after spending 13 years at the University of Virginia, where he was chair of the Department of Cell Biology and director of the Morphogenesis and Regenerative Medicine Institute. Prior to that he spent 10 years conducting research at Memorial Sloan-Kettering Cancer Center in New York City. He began his career as an Assistant Professor at the University of California, San Francisco.

    Dr. Gumbiner holds a PhD in Neurosciences from the University of California, San Francisco, and did postdoctoral training at the European Molecular Biology Laboratory in Heidelberg, Germany.

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    Molecular and Cell Biology graduate program at UW -

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    • Gumbiner Lab

      The Gumbiner Lab studies how tissues and organs are built from collections of individual cells, leading to discoveries about how animals and humans develop and how their tissues are maintained, repaired and regenerated throughout life.


Research Description

The Gumbiner Lab studies how organs and tissues are built from groups of individual cells. This research is leading to discoveries about how humans and animals develop, including how their tissues are maintained, repaired and regenerated. Understanding the mechanisms behind how these biological processes malfunction provides insights into the causes of many diseases, birth defects and approaches for potential new treatments. For more information, visit the Gumbiner Lab: