Annika Mai Hofstetter, MD, PhD, MPH

Annika Mai Hofstetter, MD, PhD, MPH

General Pediatrics

On staff since September 2014

Academic Title: Associate Professor

Research Center: Center for Clinical and Translational Research

"When my mom was seven years old, her brother died of polio. He was a healthy kid at the time, and the polio vaccine was developed just a few months later. Although over half a century has passed, we still face many challenges to vaccinating children against vaccine preventable diseases. My goal is to partner with parents, providers, public health officials and others to better understand these challenges and to improve timely receipt of needed vaccines in order to prevent serious complications and even death from diseases like polio."

  • Dr. Hofstetter is an attending physician at Seattle Children's and an associate professor of Pediatrics in the Division of General Pediatrics at the University of Washington. She is certified with the American Board of Pediatrics and has been honored with multiple awards throughout her career, including a U.S. Fulbright Scholarship. Dr. Hofstetter serves as Region X Research Chair with the Academic Pediatric Association Continuity Research Network, is co-leader of the Maintenance of Certification Influenza Vaccination Project at Seattle Children's and is a member of the Seattle Children's Influenza Steering Committee.

  • Published Abstracts

    • Hofstetter AO, Legnevall L, Herlenius E, Katz-Salamon M.
      Cardiorespiratory development in extremely preterm infants: vulnerability to infection and persistence of events beyond term-equivalent age
      Acta Paediatr. , 2008 March : 97(3)285-92 PMCID:18298775

    Other Publications

    • Bryan MA, Hofstetter AM, Ramos D, Ramirez M, Opel DJ
      Facilitators and Barriers to Providing Vaccinations During Hospital Visits.
      34556537 Hospital pediatrics, 2021 Oct. : 11(10)1137-1152
    • Stephens AB, Wynn CS, Hofstetter AM, Kolff C, Pena O, Kahn E, Dasgupta B, Natarajan K, Vawdrey DK, Lane MM, Robbins-Milne L, Ramakrishnan R, Holleran S, Stockwell MS
      Effect of Electronic Health Record Reminders for Routine Immunizations and Immunizations Needed for Chronic Medical Conditions.
      34911126 Applied clinical informatics, 2021 Oct. : 12(5)1101-1109 PMCID:PMC8674096
    • Hofstetter AM, Opel DJ, Stockwell MS, Hsu C, Zhou C, Mangione-Smith RM, Englund JA
      Associations Between Health Care Professional Communication Practices and Influenza Vaccination of Hospitalized Children.
      34217901 Academic pediatrics, 2021 Sept. : 21(7)1142-1150
    • Oster NV, Williams EC, Unger JM, Newcomb PA, deHart MP, Englund JA, Hofstetter AM
      A Risk Prediction Model to Identify Newborns at Risk for Missing Early Childhood Vaccinations.
      34402910 Journal of the Pediatric Infectious Diseases Society, 2021 Aug. 17
    • Hofstetter AM, Opel DJ, Stockwell MS, Hsu C, deHart MP, Zhou C, Mangione-Smith RM, Englund JA
      Influenza-Related Knowledge, Beliefs, and Experiences Among Caregivers of Hospitalized Children.
      34272235 Hospital pediatrics, 2021 Aug. : 11(8)815-832
    • Hofstetter AM, Schaffer S
      Childhood and Adolescent Vaccination in Alternative Settings.
      33958093 Academic pediatrics, 2021 May : 21(4S)S50-S56
    • Chabra S, Hofstetter AM
      Timely Hepatitis B Birth Dose Receipt for Newborns: Within 24 Hours.
      33234551 Hospital pediatrics, 2020 Dec. : 10(12)e18-e20
    • Ost K, Oster NV, Jacobson EN, deHart MP, Englund JA, Hofstetter AM
      Hepatitis B Vaccination of Low Birth Weight Infants in Washington State.
      33254241 American journal of perinatology, 2020 Nov. 30
    • Bryan MA, Hofstetter AM, Simon TD, Zhou C, Williams DJ, Tyler A, Kenyon CC, Vachani JG, Opel DJ, Mangione-Smith R
      Vaccination Status and Adherence to Quality Measures for Acute Respiratory Tract Illnesses.
      32041781 Hospital pediatrics, 2020 March : 10(3)199-205 PMCID:PMC7041553
    • Bryan MA, Hofstetter AM, deHart MP, Simon TD, Opel DJ
      Vaccination Status and Resource Use During Hospital Visits for Respiratory Illnesses.
      31624218 Pediatrics, 2019 Nov. : 144(5) PMCID:PMC6855809
    • Oster NV, Williams EC, Unger JM, Newcomb PA, Jacobson EN, deHart MP, Englund JA, Hofstetter AM
      Hepatitis B Birth Dose: First Shot at Timely Early Childhood Vaccination.
      31542144 American journal of preventive medicine, 2019 Oct. : 57(4)e117-e124 PMCID:PMC6802744
    • Rogers MAM, Kim C, Hofstetter AM
      Geospatial Variation in Rotavirus Vaccination in Infants, United States, 2010-2017.
      31538927 Emerging infectious diseases, 2019 Oct. : 25(10)1993-1995 PMCID:PMC6759250
    • Oster NV, Williams EC, Unger JM, Newcomb PA, Jacobson EN, deHart MP, Englund JA, Hofstetter AM
      Sociodemographic, clinical and birth hospitalization characteristics and infant Hepatitis B vaccination in Washington State.
      30930007 Vaccine, 2019 Sept. 10 : 37(38)5738-5744 PMCID:PMC6713629
    • Hofstetter AM, Jacobson EN, deHart MP, Englund JA
      Early Childhood Vaccination Status of Preterm Infants.
      31391213 Pediatrics, 2019 Sept. : 144(3)
    • Bryan MA, Hofstetter AM, deHart MP, Zhou C, Opel DJ
      Accuracy of Provider-Documented Child Immunization Status at Hospital Presentation for Acute Respiratory Illness.
      30442704 Hospital pediatrics, 2018 Dec. : 8(12)769-777
    • Henrikson NB, Zhu W, Baba L, Nguyen M, Berthoud H, Gundersen G, Hofstetter AM
      Outreach and Reminders to Improve Human Papillomavirus Vaccination in an Integrated Primary Care System.
      30003794 Clinical pediatrics, 2018 Nov. : 57(13)1523-1531
    • Hofstetter AM, Simon TD, Lepere K, Ranade D, Strelitz B, Englund JA, Opel DJ
      Parental Vaccine Hesitancy and Declination of Influenza Vaccination Among Hospitalized Children.
      30228245 Hospital pediatrics, 2018 Oct. : 8(10)628-635
    • Hofstetter AM, Lacombe K, Klein EJ, Jones C, Strelitz B, Jacobson E, Ranade D, Ward ML, Mijatovic-Rustempasic S, Evans D, Wikswo M, Bowen MD, Parashar UD, Payne DC, Englund JA
      Risk of Rotavirus Nosocomial Spread After Inpatient Pentavalent Rotavirus Vaccination.
      29212881 Pediatrics, 2018 Jan. : 141(1)
    • Hofstetter AM, Camargo S, Natarajan K, Rosenthal SL, Stockwell MS
      Vaccination Coverage of Adolescents With Chronic Medical Conditions.
      28928039 American journal of preventive medicine, 2017 Nov. : 53(5)680-688
    • Hofstetter AM, Barrett A, Camargo S, Rosenthal SL, Stockwell MS
      Text message reminders for vaccination of adolescents with chronic medical conditions: A randomized clinical trial.
      28736201 Vaccine, 2017 Aug. 16 : 35(35 Pt B)4554-4560
    • Hofstetter AM, Robinson JD, Lepere K, Cunningham M, Etsekson N, Opel DJ
      Clinician-parent discussions about influenza vaccination of children and their association with vaccine acceptance.
      28392141 Vaccine, 2017 May 9 : 35(20)2709-2715 PMCID:PMC5572763
    • Glick AF, Kjelleren S, Hofstetter AM, Subramony A
      RSV Hospitalizations in Comparison With Regional RSV Activity and Inpatient Palivizumab Administration, 2010-2013.
      28381595 Hospital pediatrics, 2017 May : 7(5)271-278
    • Hofstetter AM, Lappetito L, Stockwell MS, Rosenthal SL
      Human Papillomavirus Vaccination of Adolescents with Chronic Medical Conditions: A National Survey of Pediatric Subspecialists.
      27542999 Journal of pediatric and adolescent gynecology, 2017 Feb. : 30(1)88-95 PMCID:PMC5279719
    • Doherty M, Schmidt-Ott R, Santos JI, Stanberry LR, Hofstetter AM, Rosenthal SL, Cunningham AL
      Vaccination of special populations: Protecting the vulnerable.
      27876197 Vaccine, 2016 Dec. 20 : 34(52)6681-6690
    • Hofstetter AM, Ompad DC, Stockwell MS, Rosenthal SL, Soren K
      Human Papillomavirus Vaccination and Cervical Cytology Outcomes Among Urban Low-Income Minority Females.
      26974250 JAMA pediatrics, 2016 May 1 : 170(5)445-52
    • Siljehav V, Hofstetter AM, Leifsdottir K, Herlenius E
      Prostaglandin E2 Mediates Cardiorespiratory Disturbances during Infection in Neonates.
      26434370 The Journal of pediatrics, 2015 Dec. : 167(6)1207-13.e3
    • Hofstetter AM, DuRivage N, Vargas CY, Camargo S, Vawdrey DK, Fisher A, Stockwell MS
      Text message reminders for timely routine MMR vaccination: A randomized controlled trial.
      26424607 Vaccine, 2015 Oct. 26 : 33(43)5741-6
    • Hofstetter AM, Barrett A, Stockwell MS
      Factors impacting influenza vaccination of urban low-income Latino children under nine years requiring two doses in the 2010-2011 season.
      25082482 Journal of community health, 2015 April : 40(2)227-34 PMCID:PMC4314518
    • Hofstetter AM, Vargas CY, Camargo S, Holleran S, Vawdrey DK, Kharbanda EO, Stockwell MS
      Impacting delayed pediatric influenza vaccination: a randomized controlled trial of text message reminders.
      25812465 American journal of preventive medicine, 2015 April : 48(4)392-401
    • Hofstetter AM, LaRussa P, Rosenthal SL
      Vaccination of adolescents with chronic medical conditions: Special considerations and strategies for enhancing uptake.
      26212313 Human vaccines & immunotherapeutics, 2015 : 11(11)2571-81 PMCID:PMC4685675
    • Stockwell MS, Catallozzi M, Camargo S, Ramakrishnan R, Holleran S, Findley SE, Kukafka R, Hofstetter AM, Fernandez N, Vawdrey DK
      Registry-linked electronic influenza vaccine provider reminders: a cluster-crossover trial.
      25548331 Pediatrics, 2015 Jan. : 135(1)e75-82
    • Stockwell MS, Hofstetter AM, DuRivage N, Barrett A, Fernandez N, Vargas CY, Camargo S
      Text message reminders for second dose of influenza vaccine: a randomized controlled trial.
      25548329 Pediatrics, 2015 Jan. : 135(1)e83-91 PMCID:PMC4279072
    • Hofstetter AM, Rosenthal SL
      Factors impacting HPV vaccination: lessons for health care professionals.
      24965128 Expert review of vaccines, 2014 Aug. : 13(8)1013-26
    • Tsui J, Hofstetter AM, Soren K
      Cervical cytology screening among low-income, minority adolescents in New York City following the 2009 ACOG guidelines.
      24650625 Preventive medicine, 2014 June : 6381-6 PMCID:PMC4075324
    • Hofstetter AM, Stockwell MS, Al-Husayni N, Ompad D, Natarajan K, Rosenthal SL, Soren K
      HPV vaccination: are we initiating too late?
      24530404 Vaccine, 2014 April 7 : 32(17)1939-45
    • Hofstetter AM, Jakob K, Klein NP, Dekker CL, Edwards KM, Halsey NA, Baxter R, Williams SE, Graham PL 3rd, LaRussa P
      Live vaccine use and safety in DiGeorge syndrome.
      24685951 Pediatrics, 2014 April : 133(4)e946-54
    • Hofstetter AM, Rosenthal SL
      Health care professional communication about STI vaccines with adolescents and parents.
      23791695 Vaccine, 2014 March 20 : 32(14)1616-23
    • Broutet N, Fruth U, Deal C, Gottlieb SL, Rees H, participants of the 2013 STI Vaccine Technical Consultation.
      Vaccines against sexually transmitted infections: the way forward.
      24480024 Vaccine, 2014 March 20 : 32(14)1630-7
    • Hofstetter AM, Rosenthal SL, Stanberry LR
      Current thinking on genital herpes.
      24335720 Current opinion in infectious diseases, 2014 Feb. : 27(1)75-83
    • Hofstetter AM, Vargas CY, Kennedy A, Kitayama K, Stockwell MS
      Parental and provider preferences and concerns regarding text message reminder/recall for early childhood vaccinations.
      23624252 Preventive medicine, 2013 Aug. : 57(2)75-80
    • Hofstetter AM, Natarajan K, Rabinowitz D, Martinez RA, Vawdrey D, Arpadi S, Stockwell MS
      Timeliness of pediatric influenza vaccination compared with seasonal influenza activity in an urban community, 2004-2008.
      23678935 American journal of public health, 2013 July : 103(7)e50-8 PMCID:PMC3682625
    • Stockwell MS, Martinez RA, Hofstetter A, Natarajan K, Vawdrey DK
      Timeliness of 2009 H1N1 vaccine coverage in a low-income pediatric and adolescent population.
      21458606 Vaccine, 2013 April 12 : 31(16)2103-7
    • Hofstetter AM, Natarajan K, Martinez RA, Rabinowitz D, Vawdrey DK, Stockwell MS
      Influenza vaccination coverage and timeliness among children requiring two doses, 2004-2009.
      23219757 Preventive medicine, 2013 March : 56(3-4)165-70
    • Siljehav V, Olsson Hofstetter A, Jakobsson PJ, Herlenius E
      mPGES-1 and prostaglandin E2: vital role in inflammation, hypoxic response, and survival.
      22926547 Pediatric research, 2012 Nov. : 72(5)460-7 PMCID:PMC3647218
    • Hofstetter AO, Saha S, Siljehav V, Jakobsson PJ, Herlenius E
      The induced prostaglandin E2 pathway is a key regulator of the respiratory response to infection and hypoxia in neonates.
      17535900 Proceedings of the National Academy of Sciences of the United States of America, 2007 June 5 : 104(23)9894-9 PMCID:PMC1877988
    • Hofstetter AO, Herlenius E
      Interleukin-1beta depresses hypoxic gasping and autoresuscitation in neonatal DBA/1lacJ mice.
      15766902 Respiratory physiology & neurobiology, 2005 April 15 : 146(2-3)135-46
    • Olsson A, Kayhan G, Lagercrantz H, Herlenius E
      IL-1 beta depresses respiration and anoxic survival via a prostaglandin-dependent pathway in neonatal rats.
      12761362 Pediatric research, 2003 Sept. : 54(3)326-31


Board Certification(s)


Medical/Professional School

University of Washington, Seattle, WA
Karolinska Medico Kirurgiska Institutet, Stockholm, Stockholm
Columbia University College of Physicians & Surgeons, New York, NY

Clinical Interests

Dr. Hofstetter's research focuses on pediatric and adolescent vaccination, especially in high-risk populations. She has experience examining vaccination coverage, timeliness, and missed opportunities. She has worked on novel technology-based interventions aiming to improve vaccine uptake and reduce missed opportunities, including a recent text message vaccine reminder study targeting adolescents with chronic medical conditions. She also has a research interest in provider-parent vaccine communication and vaccine safety.