Ann E. Woolfrey, MD


On staff since May 2000

Academic Title: Professor

  • Ann E. Woolfrey, MD, is attending physician at Seattle Children’s Hospital and associate member of the Clinical Research Division at Fred Hutchinson Cancer Research Center (FHCRC). She is director of the Unrelated Marrow Donor Program for the Seattle Cancer Care Alliance.

    Nationally, she serves on the Board of Directors of the National Marrow Donor Program (NMDP), and is a member of the Cord Blood Advisory Group  and of the Histocompatibility Advisory Group for the NMDP; in addition, she serves on the National Steering Committee of the Radiation Injury Treatment Network, the Center for International Bone Marrow Transplant Research (CIBMTR)  Physician Taskforce, the CIBMTR Pediatric Transplant Steering committee, the Pediatric Bone Marrow Transplant Clinical Trials Network (PBMT-CTN) Nonmalignant disease commity, and the PBMT-CTN Cellular Therapy committee. Dr. Woolfrey’s research interests involve pediatric oncology, particularly leukemia, and processes of stem cell, blood and marrow transplant. She is involved in several studies on overcoming genetic barriers in hematopoietic stem cell transplant, identifying non-myeloablative transplants for nonmalignant disorders and investigating the use of blood stem cell and marrow transplant from HLA-compatible related and unrelated donors.

  • Award Name Award Description Awarded By Award Date
    U.S. News Top Doctor U.S. News and World Report 2012
  • Other Publications

    • Brunstein CG, Gutman JA, Weisdorf DJ, Woolfrey AE, Defor TE, Gooley TA, Verneris MR, Appelbaum FR, Wagner JE, Delaney C
      Allogeneic hematopoietic cell transplantation for hematological malignancy: relative risks and benefits of double umbilical cord blood.
      20686119 Blood, 2010 Aug. 4
    • Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders J, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD, Woolfrey AE
      Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
      20643476 The Journal of allergy and clinical immunology, 2010 July 17
    • Nemecek ER, Guthrie KA, Sorror ML, Wood BL, Doney KC, Hilger RA, Scott BL, Kovacsovics TJ, Maziarz RT, Woolfrey AE, Bedalov A, Sanders JE, Pagel JM, Sickle EJ, Witherspoon R, Flowers ME, Appelbaum FR, Deeg HJ
      Conditioning with Treosulfan and Fludarabine Followed by Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic Malignancies.
      20685259 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2010 May 25
    • Kalaycio ME, Kukreja M, Woolfrey AE, Szer J, Cortes J, Maziarz RT, Bolwell BJ, Buser A, Copelan E, Gale RP, Gupta V, Maharaj D, Marks DI, Pavletic SZ, Horowitz MM, Arora M
      Allogeneic hematopoietic cell transplant for prolymphocytic leukemia.
      19961946 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2010 April : 543-7
    • Gutman JA, Leisenring W, Appelbaum FR, Woolfrey AE, Delaney C
      Low relapse without excessive transplant-related mortality following myeloablative cord blood transplantation for acute leukemia in complete remission: a matched cohort analysis.
      19660726 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2009 Sept. : 1122-9
    • Gutman JA, McKinney SK, Pereira S, Warnock SL, Smith AG, Woolfrey AE, Hansen JA, Delaney C
      Prospective monitoring for alloimmunization in cord blood transplantation: "virtual crossmatch" can be used to demonstrate donor-directed antibodies.
      19202448 Transplantation, 2009 Feb. 15 : 415-8
    • Sanders JE, Hoffmeister PA, Woolfrey AE, Carpenter PA, Storer BE, Storb RF, Appelbaum FR
      Thyroid function following hematopoietic cell transplantation in children: 30 years' experience.
      18838614 Blood, 2009 Jan. 8 : 306-8
    • Woolfrey AE, Malhotra U, Harrington RD, McNevin J, Manley TJ, Riddell SR, Coombs RW, Appelbaum FR, Corey L, Storb R
      Generation of HIV-1-specific CD8+ cell responses following allogeneic hematopoietic cell transplantation.
      18698002 Blood, 2008 Oct. 15 : 3484-7
    • Lee SJ, Kukreja M, Wang T, Giralt SA, Szer J, Arora M, Woolfrey AE, Cervantes F, Champlin RE, Gale RP, Halter J, Keating A, Marks DI, McCarthy PL, Olavarria E, Stadtmauer EA, Abecasis M, Gupta V, Khoury HJ, George B, Hale GA, Liesveld JL, Rizzieri DA, Antin JH, Bolwell BJ, Carabasi MH, Copelan E, Ilhan O, Litzow MR, Schouten HC, Zander AR, Horowitz MM, Maziarz RT
      Impact of prior imatinib mesylate on the outcome of hematopoietic cell transplantation for chronic myeloid leukemia.
      18664621 Blood, 2008 Oct. 15 : 3500-7
    • Baron F, Sandmaier BM, Storer BE, Maris MB, Langston AA, Lange T, Petersdorf E, Bethge W, Maziarz RT, McSweeney PA, Pulsipher MA, Wade JC, Chauncey TR, Shizuru JA, Sorror ML, Woolfrey AE, Maloney DG, Storb R
      Extended mycophenolate mofetil and shortened cyclosporine failed to reduce graft-versus-host disease after unrelated hematopoietic cell transplantation with nonmyeloablative conditioning.
      17697966 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2007 Sept. : 1041-8
    • Carpenter PA, Hoffmeister P, Chesnut CH 3rd, Storer B, Charuhas PM, Woolfrey AE, Sanders JE
      Bisphosphonate therapy for reduced bone mineral density in children with chronic graft-versus-host disease.
      17531778 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2007 June : 683-90
    • Sanders JE, Im HJ, Hoffmeister PA, Gooley TA, Woolfrey AE, Carpenter PA, Andrews RG, Bryant EM, Appelbaum FR
      Allogeneic hematopoietic cell transplantation for infants with acute lymphoblastic leukemia.
      15637143 Blood, 2005 May 1 : 3749-56
    • Baron F, Maris MB, Sandmaier BM, Storer BE, Sorror M, Diaconescu R, Woolfrey AE, Chauncey TR, Flowers ME, Mielcarek M, Maloney DG, Storb R
      Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning.
      15774790 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005 March 20 : 1993-2003
    • Sanders JE, Guthrie KA, Hoffmeister PA, Woolfrey AE, Carpenter PA, Appelbaum FR
      Final adult height of patients who received hematopoietic cell transplantation in childhood.
      15454481 Blood, 2005 Feb. 1 : 1348-54
    • Hogan WJ, Maris M, Storer B, Sandmaier BM, Maloney DG, Schoch HG, Woolfrey AE, Shulman HM, Storb R, McDonald GB
      Hepatic injury after nonmyeloablative conditioning followed by allogeneic hematopoietic cell transplantation: a study of 193 patients.
      12969980 Blood, 2004 Jan. 1 : 78-84
    • Meshinchi S, Leisenring WM, Carpenter PA, Woolfrey AE, Sievers EL, Radich JP, Sanders JE
      Survival after second hematopoietic stem cell transplantation for recurrent pediatric acute myeloid leukemia.
      14652854 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2003 Nov. : 706-13
    • Bethge WA, Storer BE, Maris MB, Flowers ME, Maloney DG, Chauncey TR, Woolfrey AE, Storb R, Sandmaier BM
      Relapse or progression after hematopoietic cell transplantation using nonmyeloablative conditioning: effect of interventions on outcome.
      14550814 Experimental hematology, 2003 Oct. : 974-80
    • Georges GE, Maris M, Sandmaier BM, Malone DG, Feinstein L, Niederweiser D, Shizuru JA, McSweeney PA, Chauncey TR, Agura E, Little MT, Sahebi F, Hegenbart U, Pulsipher MA, Bruno B, Forman S, Woolfrey AE, Radich JP, Blume KG, Storb R
      Related and unrelated nonmyeloablative hematopoietic stem cell transplantation for malignant diseases.
      12430851 International journal of hematology, 2002 Aug. : 184-9
    • Woolfrey AE, Pulsipher MA, Storb R
      Non-myeloablative hematopoietic cell transplant for treatment of nonmalignant disorders in children.
      12430936 International journal of hematology, 2002 Aug. : 271-7
    • Woolfrey AE, Anasetti C, Storer B, Doney K, Milner LA, Sievers EL, Carpenter P, Martin P, Petersdorf E, Appelbaum FR, Hansen JA, Sanders JE
      Factors associated with outcome after unrelated marrow transplantation for treatment of acute lymphoblastic leukemia in children.
      11877272 Blood, 2002 March 15 : 2002-8

  • Grant Title Grantor Amount Award Date
    Adult Leukemia Research Center NIH NCI $242,509.00 March 1, 2007
    Sub-Project- BMT0201 NCI NHLBI Oct. 1, 2006
    Stem Cell Transplantation- Basic Clinical Research NIH/NHLBI $93,800.00 Aug. 1, 2006
    Gene Therapy for Fanconi Anemia NIH $479,927.00 July 24, 2006


Board Certification(s)

Internal Medicine
Pediatric Hematology-Oncology

Medical/Professional School

University of Minnesota, Minneapolis


Pediatrics, University of Chicago, Chicago


Pediatric Hematology-Oncology, University of Washington School of Medicine, Seattle