Quest to End Premature Births Worldwide Takes Momentous Step Forward

Gates Foundation grants $20 Million to GAPPS at Seattle Children’s to engage researchers from around the world in groundbreaking research

NEW DELHI & SEATTLE – Thirteen million babies are born prematurely every year, but new funding announced today will allow for pioneering research into the causes of preterm births and the development of solutions so they can be prevented.

Today, the Global Alliance to Prevent Prematurity and Stillbirth (GAPPS), an initiative of Seattle Children’s, announced a new Grand Challenges in Global Health program that will seek to discover and develop interventions to prevent preterm birth and stillbirth by limiting infection and improving nutrition. The program, called the Preventing Preterm Birth initiative, is supported by a commitment of US $20 million from the Bill & Melinda Gates Foundation.

Globally, prematurity is the leading cause of death for newborns, every year taking the lives of one million babies before their first month of life. The Preventing Preterm Birth initiative will mobilize the scientific community to discover the reasons behind prematurity and support research into novel technologies and approaches that provide real-world solutions. The initiative was announced at a joint session of the Annual Grand Challenges Meeting and the Keystone Symposia Conference, in New Delhi, India.

“The objective of the Preventing Preterm Birth initiative is to inspire new scientific research and discover causes of preterm birth that we have never known,” said Craig Rubens, MD, PhD, co-founder and Executive Director of GAPPS. “By uniting the scientific community to combat and prevent prematurity, we have the ability to make an enormous impact on global infant mortality rates.”

Smoking cessation and progesterone therapy are the only interventions proven to reduce preterm birth; two interventions difficult to deploy around the world. The Preventing Preterm Birth initiative aims to uncover at least two new maternal interventions that set prevention measures in motion for the developing and developed world.

“Preterm births claim far too many lives each year, particularly in the world’s poorest countries,” said Gary Darmstadt, Director of Family Health at the Bill & Melinda Gates Foundation. “We urgently need new, groundbreaking ideas that ensure mothers receive the necessary health interventions to help their children have a healthy start to life.”

Under the initiative, GAPPS will solicit ideas from scientists around the world through January 31, 2012. The most promising applications will be selected by a review committee of experts and asked to submit full proposals for further consideration and funding from the pool of resources provided by the Gates Foundation.

“Prematurity and stillbirth are complex global health problems that require an interdisciplinary research approach and an international commitment,” said Alan E. Guttmacher, MD, Director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) of the U.S. National Institutes of Health. “NICHD is pleased to see this new initiative that is so closely aligned with the Institute’s goals. Discovery science, whether funded by the Preventing Preterm Birth initiative, NICHD or other funders, is the foundation of long-term strategies to prevent preterm birth.”

Members of the scientific community can apply to be a sub-grantee at where information on the rules for grants can be found. Applicants will be required to also submit their ideas for catalyzing further investments in prematurity research. A video with Dr. Rubens about the Preterm Birth initiative can be viewed here:

About Grand Challenges in Global Health

Grand Challenges in Global Health is a global partnership first launched by the Gates Foundation and others in 2003 that seeks to engage the world’s most creative minds to work on scientific and technological breakthroughs for the most pressing global health and development challenges.


The Global Alliance to Prevent Prematurity and Stillbirth (GAPPS), an initiative of Seattle Children’s, leads a collaborative, global effort to increase awareness and accelerate innovative research and interventions that will improve maternal, newborn and child health outcomes around the world.

About Seattle Children’s

Seattle Children’s Hospital, Foundation and Research Institute together deliver superior patient care, advance new discoveries and treatments through pediatric research, and raise funds to create better futures for patients. Consistently ranked as one of the top 10 children’s hospitals in the country by U.S. News & World Report, Seattle Children’s Hospital specializes in meeting the unique physical, emotional and developmental needs of children from infancy through young adulthood. Through the collaboration of physicians in nearly 60 pediatric subspecialties, Seattle Children’s Hospital provides inpatient, outpatient, diagnostic, surgical, rehabilitative, behavioral, and emergency and outreach services to families from around the world.

Located in downtown Seattle’s biotech corridor, Seattle Children’s Research Institute is pushing the boundaries of medical research to find cures for pediatric diseases and improve outcomes for children all over the world. Internationally recognized investigators and staff at the research institute are advancing new discoveries in cancer, genetics, immunology, pathology, infectious disease, injury prevention, bioethics and much more.

Seattle Children’s Hospital and Research Foundation and Seattle Children’s Hospital Guild Association work together to gather community support and raise funds for uncompensated care, clinical care and research. The foundation receives nearly 80,000 gifts each year, from lemonade stand proceeds to corporate sponsorships. Seattle Children’s Hospital Guild Association is the largest all-volunteer fundraising network for any hospital in the country, serving as the umbrella organization for 450 groups of people who turn an activity they love into a fundraiser. Support from the foundation and guild association makes it possible for Seattle Children’s care and research teams to improve the health and well-being of all kids.

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