Multidimensional quantitative imaging for the biological and material sciences

Technology Overview

High-resolution multidimensional imaging is fast becoming the approach of preference for assessing morphology and anatomy of biological specimens and for many aspects of materials science including prototype assessment, reverse engineering, and model testing. The Small ANimal Tomographic Analysis (SANTA) Facility, directed by Dr. Cox, operates two high-resolution tomographs that are capable of nondestructively imaging a wide variety (and size) of biological and non-biological sample types. The micro-computed tomograph offers both standard as well as in vivo imaging modalities of samples of up to 6.8cm x 20cm at resolutions between 9 and 35 microns. The second scanner, an optical projection tomograph (OPT), is the only unit of its kind in a fee-for-service facility in the US and is ideal for assessing morphology and anatomy in small soft tissues, biopsies, and embryonic material but also can image labeled cells within some non-biological materials. The OPT can perform consecutive scans under different light sources or filters to simultaneously distinguish as many as four different anatomical or cellular structures in the one sample. Both tomographic scanners provide much greater resolution than magnetic resonance imaging, and can handle samples much larger than can be viewed by confocal microscopy.

Dr. Timothy Cox

Dr. Cox’s imaging expertise and the available state-of-the art imaging tools can be applied to a broad range of biomedical and clinical research questions involving both hard and soft tissues, as well as to non-biological hard materials. Examples of uses of this technology have included evaluation of the impact of environmental factors and genes on embryonic development, measuring bone mineral density, morphology and regeneration, evaluating phenotypic abnormalities associated with pharmaceuticals in pregnant animals, visualizing precious and fragile paleontological samples, evaluating manufacturing precision of plastic and electrical components, and for generating 3D models for software-based testing (eg. military materials).

Consequently, Dr. Cox would be interested in industry collaborations in which his expertise in multidimensional, high-resolution, quantitative imaging could contribute to biomedical, clinical, and bioengineering/engineering studies.

Stage of Development

  • Pre-clinical ex vivo
  • Pre-clinical in vivo

Partnering Opportunities

  • Collaborative research opportunity
  • Sponsored research agreement
  • Consultation agreement
  • Contract based research

Publications

  1. Hadsell D, Hadsell L, Olea W, Rijnkels M, Creighton C, Smyth I, Short K, Cox L, Cox T. In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci. Mamm Genome. 2015;26(1-2):57-79.
  2. McRay B, Cox T, Johnson J, Paranjpe A. A micro-computed tomography-based comparison of the canal transportation and centering ability of ProTaper Universal rotary and WaveOne reciprocating files. Quintessence Int. 2014;45(2):101-108.
  3. Rolfe S, Cox L, Shapiro L, Cox T. A New Landmark-Independent Tool for Quantifying and Characterizing Morphologic Variation. Image Analysis and Recognition. 2014;8814:75-83.
  4. Weyers, J, Schwartz, S, Minami, E, Carlson, D, Dupras, S, Weitz, K, Simons, M, Cox, T, Murry, C, Mahoney W. Effects of Cell Grafting on Coronary Remodeling After Myocardial Infarction. Journal of the American Heart Association. 2013;2(3):e000202-e000202.

Learn More

To learn more about partnering with Seattle Children’s Research Institute on this or other projects, please contact:

Dr. Elizabeth Aylward
Director, Office of Science-Industry Partnerships
Email
206-844-1065