Condition or Therapy: Inflammatory bowel disease (IBD); graft-versus host disease (GVHD); functional gastrointestinal disorder (FGID); functional bowel disease
Category: Cancer and Blood DisordersGastroenterology

What is the goal of this study?

We are doing this study to examine the immunology of different gastrointestinal disturbances such as inflammatory bowel diseases (IBD), graft-versus host disease (GVHD) and functional gastrointestinal disorder (FGID). We want to know why and how people develop these gastrointestinal disturbances using blood and tissue samples in order to better predict and treat the disease process.

Who can join the study?

This study might be a good fit if your child is: 

  • Currently being evaluated for IBD or functional bowel disease. This can be a new diagnosis or follow up of an established disease.

-or- 

  • Receiving a first allogeneic hematopoietic stem cell transplantation (bone marrow, peripheral blood, or cord blood transplant) at University of Washington Medical Center or Seattle Children’s Hospital

Your child must also be 6 years old or older, and weigh at least 22 pounds.

This study is also enrolling adults. Email us for more information.

What happens in the study?

For participants with IBD or FGID:

If you and your child decide to take part in the study: 

  • We will examine your child’s medical records for demographic information including race, gender and age.
  • We will take blood samples of up to 40 mL each (a little less than 3 tablespoons) depending on weight. The first blood sample will occur at the time of the endoscopy. Further sample will occur at the time of a follow up endoscopy or clinical visits. 
  • We will collect extra tissue biopsies during your child’s endoscopy for our research.
  • We will collect small stool at the time of the endoscopy.

For participants receiving a stem cell transplantation: 

If you and your child decide to take part in the study:

  • We will examine your child’s medical records for demographic information including race, gender and age. 
  • We will take blood samples up to 40 mL each (a little less than 3 tablespoons) depending on weight. The first blood sample will occur at the time 
  • If your treating team decides to perform an endoscopy for diagnosis of GVHD, we will collect extra tissue biopsies during the endoscopy for our research.
  • We will collect small stool at the time of endoscopy.
  • Your child will have a series of assessments, beginning at the time of their transplant and continuing for one year.

Who can I contact for information or to enroll?

Email the research coordinator.


Study Location(s): Seattle Children’s Hospital main campus, University of Washington Medical Center, Seattle Cancer Care Alliance
Principal Investigator: Dr. Leslie Kean