Condition or Therapy:
What is the goal of this study?
We want to look at changes in the amount of urine protein and changes in kidney function in people with nephrotic syndrome to find markers of this disease process. A marker is a biological substance that can be found in blood, urine or tissue. Markers can provide clues to a patient’s disease.
Nephrotic syndrome can be caused by:
- Minimal change disease (MCD)
- Focal segmental glomerulosclerosis (FSG)
- Membranous nephropathy (MN)
These rare diseases cause serious illness and can lead to kidney failure.
Who can join the study?
This study might be a good fit if you:
- Are 19 years or older
- Have had fewer than 30 days of treatment for nephrotic syndrome
- Have proteinuria (a condition in which urine contains an abnormal amount of protein)
- Have a plan for a kidney biopsy recommended by a doctor
What happens in the study?
If you are interested in taking part in this study, you would come in for a screening visit. If you are eligible and choose to join the study, you would come in for 5 study visits in the first year and 2 study visits each year after that. At a regularly scheduled biopsy, an extra piece of kidney tissue would be collected for research use.
During study visits, we would:
- Collect blood and urine samples
- Give you questionnaires to fill out
As part of the study, you would have a physical examination.
Who can I contact for information or to enroll?
Email the research coordinator.
Seattle Children’s Hospital main campus
Dr. Sangeeta Hingorani