Developing Treatments and Cures for Autoimmune Diseases

Dr. David Rawlings directs the Center for Immunity and Immunotherapies.Dr. David Rawlings directs the Center for Immunity and Immunotherapies.

The Center for Immunity and Immunotherapies is developing better ways to treat – and potentially cure – pediatric autoimmune diseases.

This starts in the clinic. Many of our researchers are also physicians who see where today’s treatments fall short – and come up with ideas to improve them. We bring these ideas to our labs and develop innovative gene therapies, drugs and diagnostic tests. Then we launch clinical trials to test these therapies, and make them as safe and effective as possible.

Our goal is to create a brighter, healthier future for children with multiple sclerosis, juvenile diabetes, lupus and many other autoimmune diseases.

Making Key Discoveries About the Immune System

We study how the immune system becomes dysregulated and make insights that lead to new therapies. Our team has pinpointed genes that contribute to juvenile diabetes, rheumatoid arthritis, IPEX and other autoimmune diseases.

Thanks to this research, we’ve cured more children with IPEX using stem cell transplants than any other pediatric institution in the world. Now we’re using this expertise to pursue cures for many more autoimmune diseases.

Watch Dr. Troy Torgerson explain how our research is leading to cures for immune disorders like severe combined immunodeficiency disorder (SCID).

 

Developing Gene Therapies and Innovative Drugs

We develop gene therapies that replace or repair defective genes, and drugs that are potentially safer and more effective than today’s treatments. Learn more about our current research.

Improving Diagnosis of Immune Disorders

Our Immunology Diagnostic Laboratory (IDL) develops tests that rapidly identify immune diseases and find the genes that cause them. This helps doctors worldwide diagnose immune disorders and deliver the best possible treatments to children. Learn more about the IDL.

Collaborations Accelerate Progress

We shorten the path to new treatments by partnering with other institutions and private companies. Our collaborators include researchers at the University of Washington, Fred Hutchinson Cancer Research Center, the Benaroya Research Institute at Virginia Mason, Kineta Inc. and bluebird bio Inc. Learn more about industry partnerships with Seattle Children’s Research Institute.

Help Us Pursue Breakthroughs for Children

We are getting close to curing many immune disorders. But we need your help. Private donations provide seed money for innovative projects and help us bring new therapies to children. Please make a donation or email us to learn more.

Participate in Research

You can participate in research studies and clinical trials that help us better understand pediatric diseases and transform treatment. Learn more.