Scharenberg Lab Triptych

The Scharenberg Lab is broadly organized into three teams, each focused on a specific area of cell engineering technology.

Technology Team

The technology group advances our laboratory’s ability to utilize gene editing tools in primary cells. We have three areas of focus:

 

  • The application of mRNA for transient expression of nucleases and other proteins in primary cell types
  • Methods for delivery of recombination templates
  • Development of novel nucleases

 

Our team members include:

Gene expression and delivery

 

  • Kyle Jacoby, senior staff scientist
  • Dongwook Choe, staff scientist
  • Michelle Christian, post-doctoral fellow

 

Nuclease development

 

  • Kyle Jacoby, senior staff scientist
  • Yu Chen, senior staff scientist
  • Jonathan Chu, staff scientist

 

Globin Locus Editing Team

The globin locus editing team is working to understand how to efficiently modify the hemoglobin locus in long-term reconstituting hematopoietic stem cells, and how to engraft gene-edited long-term reconstituting hematopoietic stem cells efficiently.

Our team members include:

 

  • Christopher Lux, MD, PhD, MD fellow
  • Sowmya Pattahbi, MS, PhD, senior staff scientist
  • Kyle Jacoby, senior staff scientist
  • Julia Yang, MS, staff scientist

 

T-Cell Engineering Team

The T-cell engineering team is working to develop novel technologies for engineering, manufacturing and expanding T cells for therapeutic applications in oncology, autoimmune disease and transplantation.

 

  • Jaya Sahni, PhD, senior staff scientist
  • Yumei Song, staff scientist
  • Alex Grier, graduate student