Investigating How Asthma Evolves and Affects Children
Bronchial epithelial cells differentiated at an ALI
Dr. Jason Debley's research has used epidemiological, clinical and molecular methods to understand how asthma evolves in early childhood, evaluate asthma's effect on airway structure and function, and investigate new ways to diagnose asthma in infants and toddlers with recurrent wheezing. He pioneered the measurement of exhaled nitric oxide in infants and his research has assessed the utility of this and other biomarkers for predicting asthma and decline in lung function among preschool children at risk for asthma.
The Debley Laboratory is engaged in an array of translational work investigating the role of the airway epithelium in childhood asthma. Nasal and bronchial airway epithelial cells are obtained from carefully characterized children with and without asthma, then differentiated in vitro using an air-liquid interface technique to allow for experiments investigating differential expression of innate and immunomodulatory factors by asthmatic epithelial cells, as well as differential asthmatic epithelial regulation of lung fibroblast expression of extracellular matrix, fibroblast- to-myofibroblast transformation, and airway smooth muscle proliferation.
Jason S. Debley, MD, MPH, is an attending physician and director of the Flexible Bronchoscopy Service, medical director of the Pulmonary Diagnostics Lab and medical director of the Respiratory Care Department at Seattle Children's Hospital. He is an associate professor in the Department of Pediatrics at the University of Washington School of Medicine. He received his MD from Northwestern University Medical School and completed his pediatrics internship and residency at Children's Memorial Hospital in Chicago. He completed his pediatric pulmonary fellowship at Seattle Children's and earned an MPH from the University of Washington.