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Rajagopal Lab

Publications

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  1. Whidbey C, Harrell MI, Burnside K, Ngo L, Becraft AK, Iyer LM, Aravind L, Hitti J, Adams Waldorf KM, and Rajagopal L. A hemolytic pigment of Group B Streptococcus allows bacterial penetration of human placenta. J Exp Med 2013;210(6):1265-1281. PMCID: PMC Journal – In Process.
  2. Patras KA, Wang NY, Fletcher EM, Cavaco CK, Jimenez A, Garg M, Fierer J, Sheen TR, Rajagopal L, and Doran KS. Group B Streptococcus CovR regulation modulates host immune signaling pathways to promote vaginal colonization. Cell Microbiol 2013;15(7):1154-1167. PMCID: PMC3657335.
  3. Burnside K and Rajagopal L. Regulation of prokaryotic gene expression by eukaryotic-like enzymes. Curr Opin Microbiol 2012;15(2):125-131. PMCID: PMC 3320669.
  4. Burnside K, Lembo A, Harrell MI, Klein JA, Lopez-Guisa J, Siegesmund AM, Torgerson TR, Oukka M, Molina DM, and Rajagopal L. Vaccination With a UV-Irradiated Genetically Attenuated Mutant of Staphylococcus aureus Provides Protection Against Subsequent Systemic Infection. J Infect Dis 2012;206(11):1734-1744. PMCID: PMC3488195.
  5. Burnside K and Rajagopal L. Aspects of eukaryotic-like signaling in Gram-positive cocci: a focus on virulence. Future Microbiol 2011;6(7):747-761. PMCID: PMC3236639.
  6. Burnside K, Lembo A, Harrell MI, Gurney M, Xue L, Binhtran NT, Connelly JE, Jewell KA, Schmidt BZ, de Los Reyes M, Tao WA, Doran KS, and Rajagopal L. Serine/threonine phosphatase Stp1 mediates post-transcriptional regulation of hemolysin, autolysis, and virulence of Group B Streptococcus. J Biol Chem 2011;286(51):44197-44210. PMCID: PMC3243546.
  7. Vega C, Chou S, Engel K, Harrell ME, Rajagopal L, and Grundner C. Structure and Substrate Recognition of the Staphylococcus aureus Protein Tyrosine Phosphatase PtpA. J Mol Biol 2011;413(1):24-31. PMCID: PMC3204379.
  8. Xuan Q, Poon B, Kwong J, Niles D, Schmidt B, Rajagopal L, and Gantt S. Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump. Int J Antimicrob Agents 2011;38(1):81-83.
  9. Lembo A, Gurney MA, Burnside K, Banerjee A, de los Reyes M, Connelly JE, Lin WJ, Jewell KA, Vo A, Renken CW, Doran KS, and Rajagopal L. Regulation of CovR expression in Group B streptococcus impacts blood-brain barrier penetration. Mol Microbiol 2010;77(2):431-443.
  10. Burnside K, Lembo A, de Los Reyes M, Iliuk A, Binhtran NT, Connelly JE, Lin WJ, Schmidt BZ, Richardson AR, Fang FC, Tao WA, and Rajagopal L. Regulation of hemolysin expression and virulence of Staphylococcus aureus by a serine/threonine kinase and phosphatase. PLoS ONE 2010;5:e11071. PMCID: PMC2884019.
  11. Silvestroni A, Jewell KA, Wan-Jung L, Connelly JE, Ivancic MM, Tao WA and Rajagopal L. Identification of serine/threonine kinase substrates in the human pathogen Group B Streptococcus. Journal Proteome Res 2009;8:2563-2574. PMCID: PMC2863997.
  12. Rajagopal L. Understanding regulation of Group B Streptococcal virulence factors. Future Microbiol 2009;4:201-221. PMCID: PMC2691590.
  13. Lin W-J, Walthers D, Connelly JE, Burnside K, Jewell KA, Kenney LJ and Rajagopal L. Threonine phosphorylation prevents promoter DNA binding of the Group B Streptococcus response regulator CovR. Mol Microbiol 2009;71:1477-1495. PMCID: PMC Journal-IN Process. 
  14. Rantanen MK, Lehtio L, Rajagopal L, Rubens CE and Goldman A. Structure of the Streptococcus agalactiae family II inorganic pyrophosphatase at 2.80 A resolution. Acta Crystallogr D Biol Crystallogr 2007;63:738-743. PMCID: PMC2365889.
  15. Rantanen MK, Lehtio L, Rajagopal L, Rubens CE and Goldman A. Structure of Streptococcus agalactiae serine/threonine phosphatase. The subdomain conformation is coupled to the binding of a third metal ion. FEBS J 2007;274:3128-3137. PMCID: PMC2361094.
  16. Rantanen MK, Lehtio L, Rajagopal L, Rubens CE and Goldman A. Crystallization and preliminary crystallographic analysis of two Streptococcus agalactiae proteins: the family II inorganic pyrophosphatase and the serine/threonine phosphatase. Acta Crystallogr Sect F Struct Biol Cryst Commun 2006;62:891-894. PMCID: PMC2242878.
  17. Rajagopal L, Vo A, Silvestroni A and Rubens CE. Regulation of cytotoxin expression by converging eukaryotic-type and two-component signalling mechanisms in Streptococcus agalactiae. Mol Microbiol 2006;62:941-957. PMCID: PMC2593684.
  18. Rajagopal L, Vo A, Silvestroni A and Rubens CE. Regulation of purine biosynthesis by a eukaryotic-type kinase in Streptococcus agalactiae. Mol Microbiol 2005;56:1329-1346. PMCID: PMC2366208.
  19. Shelver D, Rajagopal L, Harris TO and Rubens CE. MtaR, a regulator of methionine transport, is critical for survival of group B streptococcus in vivo. J Bacteriol 2003;185:6592-6599. PMCID: PMC262094.
  20. Rajagopal L, Clancy A and Rubens CE. A eukaryotic type serine/threonine kinase and phosphatase in Streptococcus agalactiae reversibly phosphorylate an inorganic pyrophosphatase and affect growth, cell segregation, and virulence. J Biol Chem 2003;278:14429-14441.
  21. Goel AK, Rajagopal L, Nagesh N and Sonti RV. Genetic locus encoding functions involved in biosynthesis and outer membrane localization of xanthomonadin in Xanthomonas oryzae pv. oryzae. J Bacteriol 2002;184:3539-3548. PMCID: PMC135150.
  22. Goel AK, Rajagopal L and Sonti RV. Pigment and virulence deficiencies associated with mutations in the aroE gene of Xanthomonas oryzae pv. oryzae. Appl Environ Microbiol 2001;67:245-250. PMCID: PMC92557.
  23. Rajagopal L, Sundari CS, Balasubramanian D and Sonti RV. The bacterial pigment xanthomonadin offers protection against photodamage. FEBS Lett 1997;415:125-128.

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