Welcome to the Rajagopal Lab
In the Rajagopal lab, we utilize genetic, molecular, biochemical and proteomic approaches to study infectious diseases caused by bacteria. The human pathogens that we study are Group B
. Although both GBS and
are commensal organisms, these bacteria can also become disease-causing pathogens.
Current Research Projects
Current research projects
on Group B
are focused on understanding how the pathogen migrates through different host niches during infections. Research includes identifying the environmental cues/signals that are sensed by the pathogen for regulation of toxins and other virulence factors. Our studies on
are focused on elucidating factors that regulate antibiotic resistance and virulence of the pathogen. We are also investigating how mutations in host signaling pathways affect disease susceptibility to
. This is particularly relevant as patients with genetic disorders such as Jobs syndrome and chronic granulomatous disease (CGD) are prone to recurrent and life-threatening infections due to
We hope that a greater understanding of the molecular mechanisms involved during bacterial pathogenesis will enable us to identify novel compounds that can be used to treat these bacterial infections.
is an associate professor in the
Department of Pediatrics, Division of Infectious Disease
at the University of Washington. She has adjunct faculty appointments in the Departments of
and Global Health at the University of Washington. She is also a full faculty member of the
Molecular and Cellular Biology PhD program
of the University of Washington and a course coordinator of the PABIO 551 program in the
Interdisciplinary Pathobiology PhD program
Rajagopal is a member of the
Center for Global Infectious Disease Research
at Seattle Children's Research Institute, where her laboratory is physically located. She is an internationally recognized expert on the role of novel signaling pathways in Gram-positive pathogens.
Funding for her research is in part supported by the