Manuscripts in Refereed Journals (Since 2014 Only)


  1. Gantt S, Gachelet E, Carlsson J, Barcy S, Casper C, Lagunoff M. Nelfinavir impairs glycosylation of herpes simplex virus 1 envelope proteins and blocks virus maturation. Adv Virol 2015;2015:687162. PMID25709648. PMCID: PMC4325974.
  2. Stekler JD, McKernan J, Milne R, Tapia KA, Mykhalchenko K, Holte S, Maenza J, Stevens CE, Buskin SE, Mullins JI, Frenkel LM, Collier AC. Lack of resistance to integrase inhibitors among antiretroviral-naive subjects with primary HIV-1 infection, 2007-2013. Antivir Ther 2015;20(1):77-80. PMID24831260. PMCID: PMC4312242.
  3. Manhanzva MT, Mutsvangwa J, Beck IA, Frenkel LM, Tshabalala M, Manasa J, Murahwa AT, Gwanzura L. The burden of HIV associated drug resistance mutations in an early infant diagnosis program: A glance through the paediatric window of Zimbabwe. Infect Dis Ther 2015;3(1):1000198. PMCID: PMC Journal – In Process.
  4. Lehman DA, Baeten JM, McCoy CO, Weis JF, Peterson D, Mbara G, Donnell D, Thomas KK, Hendrix CW, Marzinke MA, Frenkel L, Ndase P, Mugo NR, Celum C, Overbaugh J, Matsen FA. Risk of Drug Resistance Among Persons Acquiring HIV Within a Randomized Clinical Trial of Single- or Dual-Agent Preexposure Prophylaxis. J Infect Dis 2015;211(8):1211-1218. PMID25587020. PMCID: PMC4402339.
  5. Rossouw TM, Crane J, Frenkel LM. Ethics of HIV research in children. Lancet Infect Dis 2015;15:634-635. PMID26008836. PMCID: PMC4570465.
  6. Blanco AJ, Micek MA, Frenkel LM, Montoya P, Karagianis M, Matunha L, Gloyd S, Johnson W, Pfeiffer J. Loss to Follow-Up among HIV-Exposed Children in an HIV Clinic in Beira, Mozambique. SAGE Open 2015;5:DOI: 10.1177/2158244015590841. PMC Journal – In Process.
  7. Tchakoute CT, Hesseling AC, Kidzeru EB, Gamieldien H, Passmore JA, Jones CE, Gray CM, Sodora DL, Jaspan HB. Delaying BCG vaccination until 8 weeks of age results in robust BCG-specific T-cell responses in HIV-exposed infants. J Infect Dis 2015;211(3):338-346. PMID25108027. PMCID: PMC4318913.
  8. Hesseling AC, Jaspan HB, Black GF, Nene N, Walzl G. Immunogenicity of BCG in HIV-exposed and non-exposed infants following routine birth or delayed vaccination. Int J Tuberc Lung Dis 2015;19(4):454-462. PMID25860002. PMCID: PMC4530999.
  9. Winer RL, Huang CE, Cherne S, Stern JE, Butsch Kovacic MS, Mehta PA, Sauter SL, Galloway DA, Katzenellenbogen RA. Detection of human papillomavirus in the oral cavities of persons with Fanconi anemia. Oral Dis 2015;21(3):349-354. PMID25158861. PMCID: PMC4344428.
  10. Katzenellenbogen RA, Carter JJ, Stern JE, Butsch Kovacic MS, Mehta PA, Sauter SL, Galloway DA, Winer RL. Skin and mucosal human papillomavirus seroprevalence in persons with fanconi anemia. Clin Vaccine Immunol 2015;22(4):413-420. PMID25651924. PMCID: PMC4375352.
  11. Vliet-Gregg PA, Hamilton JR, Katzenellenbogen RA. Human papillomavirus 16E6 and NFX1-123 potentiate Notch signaling and differentiation without activating cellular arrest. Virology 2015;478:50-60. PMID25723053. PMCID: PMC4383269.
  12. Gendrin C, Lembo A, Whidbey C, Burnside K, Berry J, Ngo L, Banerjee A, Xue L, Arrington J, Doran KS, Tao WA, Rajagopal L. The Sensor Histidine Kinase RgfC Affects Group B Streptococcal Virulence Factor Expression Independent of Its Response Regulator RgfA. Infect Immun 2015;83(3):1078-1088. PMID25561709. PMCID: PMC4333453.
  13. Whidbey C, Vornhagen J, Gendrin C, Boldenow E, Samson JM, Doering K, Ngo L, Ezekwe EA, Jr., Gundlach JH, Elovitz MA, Liggitt D, Duncan JA , Adams Waldorf KM, Rajagopal L. A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury. EMBO Mol Med 2015;7(4):488-505. PMID25750210. PMCID: PMC4403049.
  14. Gendrin C, Vornhagen J, Ngo L, Whidbey C, Boldenow E, Santana-Ufret V, Clauson M, Burnside K, Galloway DP, Adams Waldorf K, Piliponsky AM, Rajagopal L. Mast cell degranulation by a hemolytic lipid toxin decreases GBS colonization and infection. Sci Adv 2015;1:e1400225. PMCID: PMC4584422.
  15. Hirata A, Hashimoto K, Katoh Y, Sakai H, Bruce AG, Rose TM, Kaneko A, Suzuki J, Nikami H, Yanai T. Characterization of Spontaneous Malignant Lymphomas in Japanese Macaques (Macaca fuscata). Vet Pathol 2015;52(3):566-572. PMID: 25248517. PMC Journal – In Process.
  16. Bruce AG, Thouless ME, Haines AS, Pallen MJ, Grundhoff A, Rose TM. Complete genome sequence of MneRV2, the pigtailed macaque RV2 rhadinovirus, and evolutionary relationship with rhesus macaque RRV and human herpesvirus 8/KSHV. J Virol 2015;89:3888-3909. PMID: 25609822, PMCID: PMC4403432.
  17. Waghmare A, Wagner T, Andrews R, Smith S, Kuypers J, Moss R, Englund J. Successful treatment of parainfluenza virus (PIV) respiratory infection with DAS181 in 3 immunocompromised children. J Pediatr Infect Dis 2015;4(2):114-118. PMCID: PMC4501511.
  18. Olson SC, Ngo-Giang-Huong N, Beck I, Deng W, Britto P, Shapiro DE, Bumgarner RE, Mullins JI, Van Dyke RB, Jourdain G, Frenkel LM. Resistance detected by pyrosequencing following zidovudine-monotherapy for prevention of HIV-1 mother-to-child-transmission. AIDS 2015;29(12):1467-1471. PMCID: PMC4618483.
  19. Ticona E, Bull ME, Soria J, Tapia K, Legard J, Styrchak SM, Williams C, Mitchell C, La Rosa A, Coombs RW, Frenkel LM. Biomarkers of inflammation in HIV-infected Peruvian men and women before and during suppressive anti-retroviral therapy (ART). AIDS 2015;29(13):1617-1622. PMC Journal – In Process.
  20. McAdams RM, Bierle CJ, Boldenow E, Weed S, Tsai J, Beyer RP, MacDonald JW, Bammler TK, Liggitt HD, Farin FM, Vanderhoeven J, Rajagopal L*, Adams Waldorf KM. Choriodecidual Group B Streptococcal Infection Induces miR-155-5p in the Fetal Lung in Macaca nemestrina. Infect Immun 2015;83(10):3909-3917. PMID26195546. PMCID: PMC4567641. *Co-Corresponding Author
  21. Adams Waldorf KM, Singh N, Mohan AR, Young RC, Ngo L, Das A, Tsai J, Bansal A, Paolella L, Herbert BR, Sooranna SR, Gough GM, Astley C, Vogel K, Baldessari AE, Bammler TK, Macdonald J, Gravett MG, Rajagopal L, Johnson MR. Uterine overdistention induces preterm labor mediated by inflammation: observations in pregnant women and nonhuman primates. Am J Obstet Gynecol 2015; available on-line 8/15/2015, in press. PMCID Journal – In Process.
  22. Whidbey C, Burnside K, Martinez RM, Gendrin C, Vornhagen J, Frando A, Harrell MI, McAdams R, Rajagopal L A Hyperhemolytic/Hyperpigmented Group B Streptococcus Strain with a CovR mutation Isolated from an Adolescent Patient with Sore Throat. Clin Res Infect Dis 2015, available on-line 9/14/2015, in press. PMCID: PMC Journal – In Process.
  23. Mugwanya KK, Wyatt C, Celum C, Donnell D, Mugo NR, Tappero J, Kiarie J, Ronald A, Baeten JM; Partners PrEP Study Team (Frenkel LM). 2015. Changes in glomerular kidney function among HIV-1-uninfected men and women receiving emtricitabine-tenofovir disoproxil fumarate preexposure prophylaxis: a randomized clinical trial. JAMA Intern Med 175(2):246-254. PMID25531343. PMCID: PMC4354899.
  24. Ndase P, Celum C, Kidoguchi L, Ronald A, Fife KH, Bukusi E, Donnell D, Baeten JM; Partners PrEP Study Team (Frenkel LM). 2015. Frequency of false positive rapid HIV serologic tests in African men and women receiving PrEP for HIV prevention: implications for programmatic roll-out of biomedical interventions. PLoS One 10(4):e0123005. PMID25885664. PMCID: PMC4401675.
  25. Kacanek D, Angelidou K, Williams PL, Chernoff M, Gadow KD, Nachman S; International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT; Frenkel LM). 2015. Psychiatric symptoms and antiretroviral nonadherence in US youth with perinatal HIV: a longitudinal study. AIDS 29(10):1227-1237. PMID26035322. PMCID: PMC4526219.
  26. Blakney AK, Tchakoute CT, Hesseling AC, Kidzeru EB, Jones CE, Passmore JA, Sodora DL, Gray CM, Jaspan HB. Delayed BCG vaccination results in minimal alterations in T cell immunogenicity of acellular pertussis and tetanus immunizations in HIV-exposed infants. Vaccine 2015;33(38):4782-4789. PMID26259542. PMCID: PMC4562895.
  27. Masson L, Salkinder AL, Olivier AJ, McKinnon LR, Gamieldien H, Mlisana K, Scriba TJ, Lewis DA, Little F, Jaspan HB, Ronacher K, Denny L, Abdool Karim SS, Passmore JS. Relationship between female genital tract infections, mucosal IL-17 production and local Th17 cells. Immunology Epub 8/25/2015, in press. PMID26302175.


  1. Staheli JP, Dyen MR, Lewis P, Barcy S. Discovery and biological characterization of two novel pig-tailed macaque homologs of HHV-6 and HHV-7. Virology 2014;471-473:126-140. PMID25461538. PMCID: PMC4312206.
  2. Bull ME, Legard J, Tapia K, Sorensen B, Cohn SE, Garcia R, Holte SE, Coombs RW, Hitti JE. HIV-1 Shedding from the Female Genital Tract is Associated with Increased Th1 Cytokines/Chemokines That Maintain Tissue Homeostasis and Proportions of CD8+FOXP3+ T Cells. J Acquir Immune Defic Syndr 2014;67(4):357-364. PMID25202922. PMCID: PMC4213308.
  3. Nachman S, Zheng N, Acosta EP, Teppler H, Homony B, Graham B, Fenton T, Xu X, Wenning L, Spector SA, Frenkel LM, Alvero C, Worrell C, Handelsman E, Wiznia A. Pharmacokinetics, Safety, and 48-Week Efficacy of Oral Raltegravir in HIV-1-Infected Children Aged 2 Through 18 Years. Clin Infect Dis 2014;58(3):413-422. PMID24145879. PMCID: PMC3890333.
  4. Mitchell C, Dross S, Beck I, Micek M, Frenkel LM. Low concentrations of HIV-1 DNA at birth delays diagnosis, complicating identification of infants for antiretroviral therapy to potentially prevent the establishment of viral reservoirs. Clin Infect Dis 2014;58(8):1190-1193. PMID24501389. PMCID: PMC3967830.
  5. Micek MA, Dross S, Blanco AJ, Beck IA, Matunha L, Seidel K, Montoya P, Matediana E, Gantt S, Gloyd S, Frenkel L. Transmission of nevirapine-resistant HIV Type 1 via breast milk to infants after single-dose nevirapine in Beira, Mozambique. J Infect Dis 2014;210(4):641-645. PMID24596282. PMCID: PMC4133577.
  6. Kantor R, Bettendorf D, Bosch RJ, Mann M, Katzenstein D, Cu-Uvin S, D'Aquila R, Frenkel L, Fiscus S, Coombs R. HIV-1 RNA Levels and Antiretroviral Drug Resistance in Blood and Non-Blood Compartments from HIV-1-Infected Men and Women enrolled in AIDS Clinical Trials Group Study A5077. PLoS One 2014;9(4):e93537. PMID24699474. PMCID: PMC3974754.
  7. Mitchell C, Roemer E, Nkwopara E, Robbins B, Cory T, Rue T, Fletcher CV, Frenkel L. Correlation between Plasma, Intracellular, and Cervical Tissue Levels of Raltegravir at Steady-State Dosing in Healthy Women. Antimicrob Agents Chemother 2014;58(6):3360-3365. PMID24687503.
  8. Beck IA, Deng W, Payant R, Hall R, Bumgarner RE, Mullins JI, Frenkel LM. Validation of an oligonucleotide ligation assay for quantification of human immunodeficiency virus type 1 drug-resistant mutants by use of massively parallel sequencing. J Clin Microbiol 2014;52(7):2320-2327. PMID24740080. PMCID: PMC4097683.
  9. Cambier CJ, Takaki KK, Larson RP, Hernandez RE, Tobin DM, Urdahl KB, Cosma CL, Ramakrishnan L. Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids. Nature 2014;505(7482):218-22.
  10. Rametse CL, Olivier AJ, Masson L, Barnabas S, McKinnon LR, Ngcapu S, Liebenberg LJ, Jaumdally SZ, Gray CM, Jaspan HB, Passmore JA. Role of semen in altering the balance between inflammation and tolerance in the female genital tract: Does it contribute to HIV risk? Viral Immunol 2014;27(5):200-206. PMID24821528.
  11. Kidzeru E B, Hesseling AC, Passmore JA, Myer L, Gamieldien H, Tchakoute CT, Gray CM, Sodora DL, Jaspan HB. In-utero exposure to maternal HIV infection alters T cell immune responses to vaccination in HIV-uninfected infants. AIDS 2014;28(10):1421-1430. PMID24785950. PMCID: PMC4333196.
  12. Gantt S, Gervassi A, Jaspan H, Horton H. The role of myeloid-derived suppressor cells in immune ontogeny. Front Immunol 2014;5:387. PMID25165466. PMC4131407.
  13. Gervassi A, Lejarcegui N, Dross S, Jacobson A, Itaya G, Kidzeru E, Gantt S, Jaspan H, Horton H. Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses. PLoS One 2014;9(9):e107816. PMID25248150. PMCID: PMC4172591.
  14. Vanderhoeven JP, Bierle CJ, Kapur RP, McAdams RM, Beyer RP, Bammler TK, Farin FM, Bansal A, Spencer M, Deng M, Gravett MG, Rubens CE, Rajagopal L*, Adams Waldorf KM. Group B streptococcal infection of the choriodecidua induces dysfunction of the cytokeratin network in amniotic epithelium: a pathway to membrane weakening. PLoS Pathog 2014;10(3):e1003920. PMID24603861. PMCID: PMC3946355. *Co-Corresponding Author.
  15. DeMaster LK, Rose TM. A critical Sp1 element in the rhesus rhadinovirus (RRV) Rta promoter confers high-level activity that correlates with cellular permissivity for viral replication. Virology 2014;448:196-209. PMID:24314650. PMCID: PMC3904427.
  16. Garrigues HJ, Rubinchikova YE, Rose TM. KSHV cell attachment sites revealed by ultra sensitive tyramide signal amplification (TSA) localize to membrane microdomains that are up-regulated on mitotic cells. Virology 2014;452:75-85. PMID: 24606685. PMCID: PMC3955009.
  17. Garrigues HJ, DeMaster LK, Rubinchikova YE, Rose TM. KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate. Virology 2014;464-465:118-133. PMCID: PMC4157101.
  18. Stockinger DE, Fong DL, Vogel KW, Durning WM, Torrence AE, Rose TM, Staheli JP, Baldessari A, Murnane RD, Hukkannen RR. Oral squamous cell carcinoma in a pigtailed macaque (Macaca nemestrina). Comp Med 2014;64:234-239. PMID: 24956217. PMCID: PMC4067589.
  19. Wagner TA, McLaughlin S, Garg K, Cheung CYK, Larsen BB, Styrchak S, Huang HC, Edlefsen PT, Mullins JI, Frenkel LM. 2014. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science 2014;345(6196):570-3. PMID: 25011556. PMCID: PMC4230336.
  20. Chung MH, Beck IA, Dross S, Tapia K, Kiarie JN, Richardson BA, Overbaugh J, Sakr SR, John-Stewart GC, Frenkel LM. Oligonucleotide Ligation Assay Detects HIV Drug Resistance Associated With Virologic Failure Among Antiretroviral-Naive Adults in Kenya. J Acquir Immune Defic Syndr 2014;67(3):246-253. PMID25140907. PMCID: PMC4197120.
  21. Dross SE, Rossi SS, Beck IA, Micek MA, Blanco AJ, Seidel KD, Montoya P, Capparelli EV, Frenkel LM. Variable and suboptimal nevirapine levels in infants given single-dose nevirapine at birth without maternal prophylaxis. AIDS 2014;28(16):2491-2493. PMID25265235. PMCID: PMC4332529.
  22. Mutsvangwa J, Beck IA, Gwanzura L, Manhanzva MT, Stranix-Chibanda L, Chipato T, Frenkel LM. Optimization of the oligonucleotide ligation assay for the detection of nevirapine resistance mutations in Zimbabwean Human Immunodeficiency Virus type-1 subtype C. J Virol Methods 2014;210C:36-39. PMID25239368. PMCID: PMC4363305.
  23. Baeten JM, Donnell D, Mugo NR, Ndase P, Thomas KK, Campbell JD, Wangisi J, Tappero JW, Bukusi EA, Cohen CR, Katabira E, Ronald A, Tumwesigye E, Were E, Fife KH, Kiarie J, Farquhar C, John-Stewart G, Kidoguchi L, Coombs RW, Hendrix C, Marzinke MA, Frenkel L, Haberer JE, Bangsberg D, Celum C. Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: an update of data from a randomised, double-blind, phase 3 trial. Lancet Infect Dis 2014;14(11):1055-1064. PMID25300863. PMCID: PMC4252589.
  24. Heffron R, Mugo N, Were E, Kiarie J, Bukusi EA, Mujugira A, Frenkel L, Donnell D, Ronald A, Celum C, Baeten JM, for the Partners PrEP Study Team. PrEP is efficacious for HIV-1 prevention among women using DMPA for contraception. AIDS 2014;28(18):2771-2776. PMCID: PMC4266161.
  25. Van Zyl GU, Frenkel LM, Chung MH, Preiser W, Mellors JW, Nachega JB. Emerging antiretroviral drug resistance in sub-Saharan Africa: novel affordable technologies are needed to provide resistance testing for individual and public health benefits. AIDS 2014;28(18):2643-2648. PMID25493592. PMCID: PMC Journal – In Process.