Welcome to the Katzenellenbogen Lab
In the Katzenellenbogen lab, we are studying Human Papillomavirus (HPV). HPV is the most common sexually transmitted infection, affecting more than 75% of the adult population. HPV is categorized as high-risk or low-risk, based on its association with cancer. Through dysregulation of normal cellular function, high-risk HPV blocks signals for DNA damage, programmed cell death and cellular arrest, all as a part of its viral life cycle. I am studying the mechanism by which high-risk HPV activates telomerase, an enzyme found normally in stem cells and is almost categorically activated in cancers, in order to understand how HPV drives cells to become malignant.
Current Research Projects
In June 2014, Katzenellenbogen received a five-year, $2 million grant from the National Institutes of Health to support a project that studies how HPV dysregulates normal cell growth and longevity to engender viral productivity. The project will demonstrate how HPV can serve as a model for universal pathways in cancer development, and will help define critical steps in oncogenesis that might be targets for screening and treatment of HPV-associated cancers.
, we hope to better understand how high-risk HPV infections lead to cancer, use HPV as a model of oncogenic progression and use HPV as a model for the life cycles of other DNA tumor viruses.
is an assistant professor in the
Department of Pediatrics, Division of Adolescent Medicine
, and an adjunct assistant professor in the Department of Global Health at the University of Washington. She is a member of the
Center for Global Infectious Disease Research
at Seattle Children's Research Institute, where her laboratory is physically located. She is also a member of the
in the Department of Global Health; the UW Global Center for Integrated Health of Women, Adolescents and Children (
Pediatric Infectious Disease training program
; and the
Adolescent Medicine training program
. Dr. Katzenellenbogen is an affiliate of the
Fred Hutchinson Cancer Research Center
Center for AIDS and STD
. She is an emerging expert on the role of post-transcriptional regulation of hTERT; funding for her research is in part supported by the