Center for Global Infectious Disease Research

The Center for Global Infectious Disease Research translates basic biology into new ways to diagnose, treat and prevent infectious diseases that impact children and adults worldwide. Learn more about the CGIDR.

Meet Us

Our Vision

We will use scientific discovery to understand, treat, prevent and cure infectious disease, developing solutions that help children grow into healthy adults.

Accelerating Progress Toward Cures

  • Working to Prevent Pediatric HIV

    Dr. Lisa Frenkel is developing affordable ways to prevent HIV, and studying key issues such as mother-to-child HIV transmission.

  • Monitoring Bacteria Outbreaks

    Dr. Scott Weissman studies how antibiotic-resistant bacteria emerge, and develops innovative ways to identify and monitor them.

Careers

Developing groundbreaking treatments takes more than just the right ideas. It also takes the right people – and the CGIDR is recruiting new members.

  • If you are looking for a job opportunity, please visit our careers page.
  • If you would like information about potential opportunities, or if you would like to volunteer in our research center, please email us.

Publications

Adams Waldorf KM, Stencel-Baerenwald JE, Kapur RP, Studholme C, Boldenow E, Vornhagen J, Baldessari A, Dighe MK, Thiel J, Merillat S, Armistead B, Tisoncik-Go J, Green RR, Davis MA, Dewey EC, Fairgrieve MR, Gatenby JC, Richards T, Garden GA, Diamond MS, Juul SE, Grant RF, Kuller L, Shaw DWW, Ogle J, Gough GM, Lee W, English C, Hevner RF, Dobyns WB, Gale M Jr., Rajagopal L. Fetal brain lesions after subcutaneous inoculation of Zika Virus in a pregnant nonhuman primate. Nat Med 2016; available online 9/12/2016, in press. PMID27618651. PMC Journal – In Progress.

Bruce AG, Horst JA, Rose TM (2016). Conservation of the glycoprotein B homologs of the Kaposi’s sarcoma-associated herpesvirus (KSHV/HHV8) and old world primate rhadinoviruses of chimpanzees and macaques. Virology 494:29-46. PMCID Journal – In Process.

Blakney AK, Tchakoute CT, Hesseling AC, Kidzeru EB, Jones CE, Passmore JA, Sodora DL, Gray CM, Jaspan HB. Delayed BCG vaccination results in minimal alterations in T cell immunogenicity of acellular pertussis and tetanus immunizations in HIV-exposed infants. Vaccine 2015;33(38):4782-4789. PMID26259542. PMCID: PMC4562895.

Gendrin C, Vornhagen J, Ngo L, Whidbey C, Boldenow E, Santana-Ufret V, Clauson M, Burnside K, Galloway DP, Adams Waldorf K, Piliponsky AM, Rajagopal L. Mast cell degranulation by a hemolytic lipid toxin decreases GBS colonization and infection. Sci Adv 2015;1:e1400225. PMCID: PMC4584422.

Ticona E, Bull ME, Soria J, Tapia K, Legard J, Styrchak SM, Williams C, Mitchell C, La Rosa A, Coombs RW, Frenkel LM. Biomarkers of inflammation in HIV-infected Peruvian men and women before and during suppressive anti-retroviral therapy (ART). AIDS 2015;29(13):1617-1622. PMC Journal – In Process.

Bruce AG, Thouless ME, Haines AS, Pallen MJ, Grundhoff A, Rose TM. Complete genome sequence of MneRV2, the pigtailed macaque RV2 rhadinovirus, and evolutionary relationship with rhesus macaque RRV and human herpesvirus 8/KSHV. J Virol 2015;89:3888-3909. PMID25609822, PMCID: PMC4403432.

Waghmare A, Wagner T, Andrews R, Smith S, Kuypers J, Moss R, Englund J. Successful treatment of parainfluenza virus (PIV) respiratory infection with DAS181 in 3 immunocompromised children. J Pediatr Infect Dis 2015;4(2):114-118. PMCID: PMC4501511.

Vliet-Gregg PA, Hamilton JR, Katzenellenbogen RA. Human papillomavirus 16E6 and NFX1-123 potentiate Notch signaling and differentiation without activating cellular arrest. Virology 2015;478:50-60. PMID25723053. PMCID: PMC4383269.

Gantt S, Gachelet E, Carlsson J, Barcy S, Casper C, Lagunoff M. Nelfinavir impairs glycosylation of herpes simplex virus 1 envelope proteins and blocks virus maturation. Adv Virol 2015;2015:687162. PMID25709648. PMCID: PMC4325974.

Latest News

  • Seattle scientists first to show monkey model of Zika damage
    09.12.16 – The Seattle Times
    Seattle researchers infected a pregnant, 9-year-old macaque monkey with Zika virus, becoming the first to demonstrate the terrible effects of the disease in the fetus of a nonhuman primate. The work is meant to put researchers on the path to testing possible therapies.
  • Research on Common Bacteria Could Prevent Stillbirths, Premature Births
    03.10.15 – Seattle Children's on the Pulse
    A study led by Seattle Children’s Research Institute and published today in EMBO Molecular Medicine, titled “A Streptococcal Lipid Toxin Induces Membrane Permeabilization and Pyroptosis Leading to Fetal Injury,” reveals new information on the common bacteria Group B Streptococcus (GBS). Researchers hope these discoveries could one day be used to prevent premature births and stillbirths.

Key Partnerships

Collaborations and partnerships are integral to the CGIDR’s approach. Our investigators work closely with colleagues at the University of Washington, Fred Hutchinson Cancer Research Center and other institutions.

Participate in Research

Help us answer questions about childhood health and illness, and help other children in the future. Learn more.