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CDT Research Cores

High-Throughput Data Analysis Core

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Core Description

The mission of Seattle Children’s High-Throughput Data Analysis Core (HAC) is to enable biomedical discoveries by translating data to knowledge. 

We accelerate and optimize research through intuitive, reliable and powerful analysis. It takes more than just a core service to achieve research advances, which is why our philosophy is to work as your collaborator in the discovery process.

We are a not-for-profit research core – our services are available at cost to the research community. We provide the research community with analysis and integration expertise (statistics, bioinformatics, software, large datasets and databases) as well as data acquisition (proteomics) services. We are located in downtown Seattle and are tele-enabled for remote collaborations. Our services are available for individual project sections and phases or for the full cycle of your project including funding applications. The core is led by Eugene Kolker, PhD.

Services and Expertise

HAC services are available at cost to the research community. Contact us for pricing information.

Full-service LCMS (liquid chromatography mass spectrometry) services

  • Experimental design
  • Sample preparation
  • Data acquisition
  • Data analysis

Custom data analysis and integration of large and small OMICS (genomics, proteomics, transcriptomics, microarrays, etc.) datasets collected anywhere

  • Statistical services
  • Software development and engineering
  • Informatics (bioinformatics, health informatics)
  • Database development and management

Resources and Equipment

We are happy to provide letters of support and resource page information to our collaborators for grant applications. Please contact us for resource information. Our equipment and analysis toolkit includes:

  • LTQ-Velos mass spectrometer (Thermo Scientific) inline with an Eksigent 2D+ UPLC for data acquisition
  • Agilent 1100 HPLC system for sample preparation and fractionation
  • Next Advance Bullet Blender homogenizer and a KingFisher magnetic bead handler
  • JANUS robotic liquid handler (Perkin Elmer)
  • High-performance super-computing cluster commercial-and-in-house–developed data analysis software, including our web-based proteomics data analysis environment, SPIRE 

HAC Philosophy

We believe that the key to answering critical research questions lies in the data generated by our collaborators. We develop innovative methods to unlock this knowledge, use them to benefit you, and share our methods with the community through publications and online tools.

We support data democratization: straightforward, equal and sustainable access to data, computing and analysis resources will enable better research. The free and open exchange of ideas is essential to scientific progress – the Data Enabled Life Sciences Alliance is one example of how researchers can support one another with the collaborative use of data.

We are passionate about collaboration! The exciting trans-disciplinary work we do with our collaborators fuels our mutual success. We give our collaborators the tools they need to discover cures and publish their research. 

More Information

Please contact us if you are interested in collaborating, would like a quote on sample analysis or would like to learn more.


Gregory Yandl, business development specialist

Core director

Eugene Kolker, PhD 

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