Welcome to the Maves Lab

The Maves lab investigates how heart and muscle cells develop, with the goal of making discoveries that lead to new treatments for muscular dystrophy and heart disorders.

Pursuing Innovative Treatments for Muscular Dystrophy

Transgenic zebrafish larvae with fluorescent muscle

Transgenic zebrafish larvae with fluorescent muscle.

Dr. Lisa Maves and her colleagues are working to make muscle cells invulnerable to muscular dystrophy, a disease that weakens a person's muscles until they stop working. The lab's current research uses zebrafish and mouse models of muscular dystrophy to determine why some types of muscle fibers resist muscular dystrophy, while others are susceptible to it. The Maves team uses this knowledge to pursue gene and drug therapies that could lessen the disease's effects – or cure it altogether.

Investigating How Heart Cells Form

The lab collaborates with Dr. Mark Majesky to study how different types of heart muscle cells form and how errors in this process cause heart defects. One of the team's goals is to understand the genetic pathways that control how stem cells differentiate into heart muscle cells. Ultimately, the researchers hope these studies will improve our knowledge of how to use stem cells to repair heart defects.

Investigator Biography

Lisa Maves PhD  

Lisa Maves, PhD, is an acting assistant professor of pediatrics at the University of Washington School of Medicine. Maves received her PhD from the University of Washington and completed postdoctoral research at the University of Oregon and at Fred Hutch. She was a staff scientist at Fred Hutch before joining Seattle Children's Research Institute in 2012.

Email Lisa Maves, PhD.

Selected Publications

Dr. Lisa Maves has authored many research papers, including the selected publications listed below. To see more of Maves's publications, view a complete list on PubMed.

  1. Paige, SL, Thomas, S, Stoick-Cooper, CL, Wang, H, Maves, L, Sandstrom, S, Pabon, L., Reinecke, H, Pratt, G, Keller, G, Moon, RT, Stamatoyannopoulos, J, Murry, CE. 2012. A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Cell 151, 221-232.
  2. Maves L, Tyler, A, Moens, CB, Tapscott, SJ. 2009. Pbx acts with Hand2 in early myocardial differentiation. Dev. Biol. 333: 409-418.
  3. Maves L, Waskiewicz AJ, Paul B, Cao Y, Tyler A, Moens CB and Tapscott SJ. 2007. Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation. Development 134: 3371-3382.