CIPO Postcard Image

Seattle Children’s Research Institute hosted the 4th International Conference on Immunotherapy in Pediatric Oncology (CIPO2015) on Sept. 25 and 26, 2015, in Seattle. The conference, entitled “Examining the Emerging Therapeutic Potential of Immunotherapy in Pediatric Oncology,” brought together worldwide leaders to discuss the latest immunotherapy research in the field of pediatric oncology. Over 200 attendees from 11 different states and 15 different countries participated in the event.

The conference program is included below along with the videos of approved presentations.

Conference Session Topics

  • High-Dimensional Analysis of T Cells
  • Tumor Microenvironment as a Barrier to Immunotherapy
  • Immunologic Clearance of Tumor – GVL/GVT as Human Model System and Adoptive Cell Therapies for Pediatric Cancers
  • Antibody-Based Therapies for Childhood Cancers

Scientific Steering Committee

  • Michael C. Jensen, MD, CIPO2015 chair, Seattle Children’s Research Institute, Seattle, Washington
  • Catherine Bollard, MD, MBChB, FRACP, FRCPA, Children’s National, D.C.
  • W. Nicholas Haining, BM, BCh, Dana–Farber Cancer Institute/Harvard University, Boston, Massachusetts
  • Rupert Handgretinger, MD, PhD, University Children’s Hospital, Tübingen, Germany
  • Leslie S. Kean, MD, PhD, Seattle Children’s Research Institute, Seattle, Washington
  • Crystal Mackall, MD, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
  • Leonid S. Metelitsa, MD, PhD, Texas Children’s Cancer Center, Houston, Texas
  • Paul M. Sondel, MD, PhD, University of Wisconsin, Madison – Wisconsin

Program

Friday, Sept. 25, 2015

Plenary Presentation

Engineering T Cells to Eradicate Tumors: Starting with the TCR and Working In
Philip D. Greenberg, MD
Fred Hutchinson Cancer Research Center

Session I: High-Dimensional Analysis of T Cells

Epigenetic Landscape of T Cell Exhaustion
W. Nicholas Haining, BM, BCh
Dana-Farber Cancer Institute, Harvard University

Enhancers Delineate Disease-Associated Regulatory Nodes in T Cells (video)
Golnaz Vahedi, PhD
Penn Institute for Immunology, University of Pennsylvania

Application of Genomics to Identify Immunotherapy Targets for Pediatric Malignancies
Javed Khan, MD
National Cancer Institute, National Institutes of Health

Abstract: Analysis of CD19 CAR T Cells During Therapy in Relapsed Acute Lymphoblastic Leukemia Pediatric and Young Adult Patients (video)
Olivia Finney, PhD
Seattle Children’s Research Institute

Dissecting Tumor Heterogeneity With Single-Cell Transcriptomics (video)
Alex K. Shalek, PhD
Massachusetts Institute of Technology

Special Lunch Presentation

Immunogenomics to Create New Therapies for High-Risk Childhood Cancers
Crystal Mackall, MD
National Cancer Institute, National Institutes of Health

Session II: Tumor Microenvironment as a Barrier to Immunotherapy

Exploiting Natural and Engineered Properties of NKT Cells for Immunotherapy of Neuroblastoma (video)
Leonid S. Metelitsa, MD, PhD
Texas Children’s Cancer Center/Baylor College of Medicine

Significance of Tumor-Associated Macrophages in Pediatric Neural Tumors
Shahab Asgharzadeh, MD
University of Southern California

Abstract: NKT Cells Selectively Target M2-like Macrophages in Neuroblastoma Tumor Microenvironment (video)
Amy Courtney, PhD
Texas Children’s Cancer Center/Baylor College of Medicine

Abstract: Genetically Engineered Macrophages: Overcoming the Brain Tumor Microenvironment (video)
Nicole Perry Lieberman, PhD
Seattle Children’s Research Institute

Manipulating Tumor Microenvironment for Immunotherapy of Neuroblastoma
Gianpietro Dotti, MD
University of North Carolina, Chapel Hill

Abstract: Targeting Chondroitin Sulfate Glycans in Childhood Cancer (video)
Htoo Zarni Oo, MD, PhD
Vancouver Prostate Centre, University of British Columbia

Abstract: Durable Immune Control of Acute Lymphoblastic Leukemia Requires a Multi-Antigen Immune Response (video)
Alix Seif, MD, MPH
The Children’s Hospital of Philadelphia

Hematopoietic Stem Cell Activation, Myeloid Derived Suppressor Cell Formation and Targeting Immune Suppression in the Early Metastatic Microenvironment
Rosandra N. Kaplan, MD
National Cancer Institute, National Institutes of Health

Saturday, Sept. 26, 2015

Plenary Presentation

Enhancing the IQ of CAR T Cells Using the Synthetic Biology Tool Box (video)
Michael C. Jensen, MD
Seattle Children’s Research Institute

Session III: Immunologic Clearance of Tumor – GVL/GVT as Human Model System and Adoptive Cell Therapies for Pediatric Cancers

Functional Determinants of Highly Active Cell Therapy
Stephan A. Grupp, MD, PhD
The Children’s Hospital of Philadelphia

Abstract: Molecular Determinants of CD19 Immunoediting in Acute Lymphoblastic Leukemia
Andrei Thomas-Tikhonenko, PhD
The Children’s Hospital of Philadelphia

Abstract: Pre-Clinical and Clinical Development of CD22-Targeted CAR T Cells (video)
Terry Fry, MD
National Cancer Institute, National Institutes of Health

Abstract: Dual Targeting of CD19 and CD22 on B-ALL Using a Single Bispecific Chimeric Antigen Receptor (video)
Haiying Qin, MS
National Cancer Institute, National Institutes of Health

Optimizing Adoptive Immunotherapy for Cancer (video)
Crystal Mackall, MD
National Cancer Institute, National Institutes of Health

Abstract: Adoptive Immunotherapy of Glypican-3 Expressing Solid Tumors
Andras Heczey, MD
Texas Children’s Hospital

T Cells as Biotherapeutics for Solid Tumors (video)
Stephen Gottschalk, MD
Texas Children’s Cancer Center/Baylor College of Medicine

Abstract: Adoptive T Cell Immunotherapy Targeting the Minor Histocompatibility Antigen HA-1 (video)
Robson Dossa, PhD
Fred Hutchinson Cancer Research Center

Abstract: Naïve T Cell Depletion of Hematopoietic Stem Cell Grafts as a Platform for Immunotherapy
Marie Bleakley, MD, PhD
Fred Hutchinson Cancer Research Center

Allogeneic Transplantation as a Platform for Post-Transplant Immunotherapy (video)
Rupert Handgretinger, MD, PhD
University Children’s Hospital, Tübingen, Germany

Session IV: Antibody-Based Therapies for Childhood Cancers

Anti-GD2 mAb and Next Generation mAb-Based Agents, KIR, Cytokines and Combination Therapy (video)
Paul M. Sondel, MD, PhD
University of Wisconsin – Madison

Targeting GD2 With 3F8 and Targeting B7-H3 With 8H9: Lessons Learned and Next Generation Therapeutics (video)
Nai-Kong V. Cheung, MD, PhD
Memorial Sloan Kettering Cancer Center

Bi-Specific Approaches to Cancer Immunotherapy Using the Dual-Affinity Re-Targeting (DART) Platform
Jon M. Wigginton, MD
MacroGenics, Inc.

Abstract: Modifying CD19 Eng T Cells to Express Costimulatory Molecules
Mireya Paulina Velasquez, MD
Texas Children’s Hospital/Baylor College of Medicine

Abstract: Enhancing the Graft-Versus-Tumor Effect Against Neuroblastoma Using an Anti-GD2 Immunocytokine (video)
Christian M. Capitini, MD
University of Wisconsin – Madison

Abstract: Cancer-Targeted IL-12 Controls Human RMS by Senescence Induction and Differentiation (video)
Karin Schilbach, PhD
University Children’s Hospital, Tübingen, Germany

Abstract: Effective Ablation of Chimeric Antigen Receptor-Modified T Cells for Acute Myeloid Leukemia with Alemtuzumab (video)
Sarah K. Tasian, MD
The Children’s Hospital of Philadelphia

Taking Lemons and Making Lemonade: Clues from Graft-Versus-Host Disease to Design Successful Immunotherapy (video)
Leslie S. Kean, MD, PhD
Seattle Children’s Research Institute

Acknowledgements

A special thanks to Bristol-Myers Squibb and Pfizer for their unrestricted educational grants in support of this event.