The Sathyanarayana Lab’s research includes:
The Infant Development and Environment Study (TIDES)
Dr. Sheela Sathyanarayana is the clinical director and site principal investigator for TIDES, which looks at whether a pregnant woman’s exposure to common chemicals influences her baby’s development. The study zeroes in on the impact of phthalates – chemicals that make plastics soft, and are present in food and everyday products. Phthalates alter hormone concentration and affect reproductive development in animal studies. We are trying to see if the same happens in humans too.
In the study’s first phase, we showed that prenatal exposure to phthalates in our diet and homes may affect the reproductive tract development in boys but not in girls. These results were affected by the amount of stress that the mother reported during pregnancy. We also found that women’s attitudes about phthalates and other environmental chemicals vary widely and can influence their consumer choices and the amount of these chemicals to which they are exposed.
In 2015, the National Institutes of Health provided funding to continue TIDES. This enables us to follow study participants to see how chemical exposures affect their development in the preschool years.
The study is led and coordinated by Dr. Shanna Swan’s team at Mount Sinai Medical Center. The four clinical centers are Seattle Children’s Research Institute; the University of Minnesota; the University of Rochester; and the University of California, San Francisco.
If your family participated in TIDES, you can stay up to date on our progress by visiting our TIDES participant page.
Genetics and the Environment Associated With Male Reproduction (GEAR)
GEAR aims to understand how male babies’ genes help govern reproductive development, and how phthalates influence this relationship.
Sathyanarayana is the principal investigator of this study, and it takes place at the same TIDES sites. We are focusing this research on male infants who participate in the TIDES study.
Prenatal Environmental Reproductive Hormone Concentrations (PERCH)
The TIDES study found that phthalate exposure can cause babies to be born with an unusually long – or short – distance between their genitals and anus. This may indicate that phthalate exposure affects how reproductive organs develop.
PERCH takes a closer look at this phenomenon, with hopes of pinpointing how phthalates alter reproductive development. The study uses data and specimens from TIDES participants to investigate the role of prenatal sex steroid hormones as a link between first trimester phthalate exposure and newborn anogenital distance (AGD).
Preventing Environmental Exposures in Pregnancy (PEEPS)
The PEEPS study’s purpose was to determine how to reduce exposures to phthalates and bisphenol A (BPA), which are environmental chemicals commonly found in food. We developed two strategies, and compared how they affected the environmental chemical concentrations in the bodies of study participants.
The first intervention provided families with educational materials on how to decrease exposures, and with food storage containers made of stainless steel and glass, instead of plastic. The families were asked to follow these educational guidelines and use these alternative containers to the best of their abilities for a five-day period.
The second intervention provided families with a fresh food diet and alternative food storage containers for a five-day period.
We expected to see no significant change in environmental chemical concentrations in the first group, and a decrease in environmental chemical concentrations in the second group.
While we saw no significant change in concentrations in the first group, we saw a significant increase in BPA and phthalate concentrations for the group that was given fresh food and alternative storage containers.
This was unexpected, so we tested the foods that participants were given and found high concentrations of the chemicals in spices and high-fat dairy. Our results show that, without regulations to reduce phthalate and BPA concentrations in food production, it may be difficult to develop effective interventions.
Our results were published in a paper in the Journal of Exposure Science and Environmental Epidemiology.
To learn more about these studies and our overall research, please email Garry Alcedo, the Sathyanarayana Lab’s research associate.