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Center for Immunity and Immunotherapies

Our Vision

CIIT researchers study rare and common disorders that yield powerful insights into the immune system. We use these insights to pursue innovative therapies for pediatric diseases and conditions.


Engineering and Flow-Cytometric Analysis of Chimeric LAGLIDADG Homing Endonucleases from Homologous I-OnuI-Family Enzymes. Baxter SK, Scharenberg AM, Lambert AR. Methods Mol Biol. 2014;1123:191-221. doi: 10.1007/978-1-62703-968-0_14.


The T-cell-dependent antibody response assay in nonclinical studies of pharmaceuticals and chemicals: Study design, data analysis, interpretation. Lebrec H, Molinier B, Boverhof D, Collinge M, Freebern W, Henson K, Mytych DT, Ochs HD, Wange R, Yang Y, Zhou L, Arrington J, Christin-Piché MS, Shenton J. Regul Toxicol Pharmacol. 2014 Feb 22. pii: S0273-2300(14)00032-4. doi: 10.1016/j.yrtph.2014.02.008. 


Suppressor of cytokine signaling 3 expression is diminished in sinonasal tissues from patients with chronic rhinosinusitis with nasal polyps. Hulse KE, Chaung K, Seshadri S, Suh L, Norton JE, Carter RG, Kern RC, Conley DB, Chandra RK, Tan BK, Peters AT, Grammer LC 3rd, Harris KE, Torgerson TR, Kato A, Schleimer RP. J Allergy Clin Immunol. 2014 Jan;133(1):275-7.e1. doi: 10.1016/j.jaci.2013.08.015.


A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. Dai X, James RG, Habib T, Singh S, Jackson S, Khim S, Moon RT, Liggitt D, Wolf-Yadlin A, Buckner JH, Rawlings DJ. J Clin Invest. 2013 May 1;123(5):2024-36. doi: 10.1172/JCI66963.

Latest News

  • Seattle Children’s Research Institute and Kineta launch the Alliance for Children’s Therapeutics
    6.11.14 – Press Release
    Seattle Children’s Research Institute and Kineta Inc. launched the Alliance for Children’s Therapeutics, a first-of-its-kind collaboration created to speed development of medications for children with lupus nephritis, and other autoimmune diseases like multiple sclerosis, Type 1 diabetes and rheumatoid arthritis.
  • Saving lives with SCID screenings
    1.15.14 – Seattle Children’s On the Pulse
    On Jan. 1, years of work by Seattle Children’s research and clinical staff came to fruition when a test for severe combined immunodeficiency (SCID) was added to Washington’s newborn screening panel for all babies born in our state.
  • Researchers uncover clues about Chagas disease
    4.17.13 – Seattle Children’s On the Pulse
    An international team of scientists in Seattle and Argentina has uncovered a surprising role for one type of immune cell in controlling Trypanosoma cruzi, a parasite that causes Chagas disease.

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