Center for Developmental Therapeutics

Meet Us

What We Do

The CDT uses studies of childhood diseases and development to identify mechanisms and principles that can be translated into children’s health improvements.

Featured Research

  • Every Heart Counts

    An aggressive transplant strategy plus exceptional post-transplant care equals better outcomes for even the most fragile children.

  • Participate in Research

    Help us answer questions about childhood health and illness, and help other children in the future.


Reproducibility: In praise of open research measures. Nature. 2013 Jun 13;498 (7453):170. doi: 10.1038/498170b. Kolker E.

Prepregnancy body mass index and congenital heart defects among offspring: a population-based study. Congenit Heart Dis. 2013 Mar-Apr;8 (2):131-41. doi: 10.1111/j.1747-0803.2012.00714.x. Epub 2012 Sep 12. Madsen NL, Schwartz SM, Lewin MB, Mueller BA.

Kawasaki disease and soy: potential role for isoflavone interaction with Fcγ receptors. Pediatr Res. 2013 Feb;73 (2):130-4. doi: 10.1038/pr.2012.168. Epub 2012 Nov 20. Portman MA.

C-Myc induced compensated cardiac hypertrophy increases free fatty acid utilization for the citric acid cycle. J Mol Cell Cardiol. 2013 Feb;55:156-64. doi: 10.1016/j.yjmcc.2012.07.005. Olson AK, Ledee D, Iwamoto K, Kajimoto M, O'Kelly Priddy C, Isern N, Portman MA.

Our Experts in the Media

  • Big Biology: The ’Omes Puzzle
    09.27.13 – Nature
    ’Omics bashing is in fashion as the number of scientific words ending in -ome skyrockets into the thousands. In an interview with Nature, Dr. Eugene Kolker points out that some ’omics research accelerates progress toward understanding many diseases.
  • Pursuing Solutions to Kawasaki Disease
    09.19.13 – Northwest Asian Weekly
    Kawasaki disease affects roughly one in 6,000 children under age 5, but that number is much higher among Asian and Pacific Islanders than other populations. The Portman Research Group is developing new tests for the disease, investigating what causes it, and pursuing more effective treatments.
  • How Data Is Turning the Tides Against Disease
    07.20.13 – GeekWire
    Powerful computing and affordable genetic analysis are improving our understanding of the human body and leveling the playing field against disease. In an interview with GeekWire radio, Dr. Eugene Kolker offers a glimpse into this world and explores the rising trend of personal genome sequencing.
  • What Makes Anesthetics Work
    12.23.11 – Science Daily
    A research team led by Drs. Phil Morgan and Margaret Sedensky identified the cells that respond to anesthesia in an organism known as C. elegans. This is a key step toward unlocking the mysteries of how anesthetics work in children and in adults.