Troy R Torgerson, MD, PhD

Professional History

Board Certified:

Pediatric Rheumatology

Medical/Professional School:

Vanderbilt University School of Medicine, Nashville

Residency:

University of Washington School of Medicine, Seattle, Pediatrics

Fellowship:

University of Washington School of Medicine, Seattle, Pediatric Rheumatology

Description of Research:

I am co-director of the Immunodeficiency Molecular Diagnostics Laboratory.

My research interests relate to the identification of basic cellular mechanisms that jointly promote autoimmunity and immunodeficiency. My research is focused on studies of the molecular basis of immune dysregulation present in patients with immune dysregulation, polyendocrinopathy,enteropathy, X-linked (IPEX). The genetic defect present in this syndrome alters the development and function of regulatory T cells, which are required for controlling immune responses. I am a member of the Society for Pediatric Research and coordinate several joint clinical research protocols designed to optimize HSCT treatment in PIDD.

I also participate in the clinical care of patients with immune deficiency and autoimmune disorders at Seattle Children's Hospital and coordinate care for immunodeficient patients treated by hematopoietic stem cell transplant (HSCT). My clinical interests include the diagnosis and management of children and adults with primary immunodeficiency diseases (PIDDs) and autoimmune disorders in children.

Key Publications:

Burroughs LM, Storb R, Leisenring WM, Pulsipher MA, Loken MR, Torgerson TR, Ochs HD, Woolfrey AE. Intensive postgrafting immune suppression combined with nonmyeloablative conditioning for transplantation of HLA-identical hematopoietic cell grafts: results of a pilot study for treatment of primary immunodeficiency disorders. Bone Marrow Transplant. Oct 2007;40(7):633-642.

Harmeling BR, Ziegler S, Torgerson TR, Chen L, Peng B, Ochs HD, Rawlings DJ, Miao CH. Regulation of Factor VIII-specific immune responses in a plasmid DNA treated Hemophilia A mouse model by transgenic FOXP3+CD4+ regulatory T cells. Mol Ther. May 2007:15(Suppl 1):S97.

Heltzer ML, Choi JK, Ochs HD, Sullivan KE, Torgerson TR, Ernst LM. A potential screening tool for IPEX syndrome. Pediatr Dev Pathol. Mar-Apr 2007;10(2):98-105.

Humblet-Baron S, Sather B, Anover S, Becker-Herman S, Kasprowicz DJ, Khm S, Nguyen T, Hudkins-Loya K, Alpers CD, Ziegler SF, Ochs HD, Torgerson TR, Campbell DJ, Rawlings DJ. Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis. J Clin Invest. Feb 2007;117(2):407-418.

Ochs HD, Gambineri E, Torgerson TR. IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity. Immunol Res. 2007;38(1-3):112-121.

Ochs HD, Torgerson TR. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked inheritance: model for autoaggression. In: Shurin MR, Smolkin YS, eds. Immune-Mediated Diseases: From Theory to Therapy. New York, N.Y.: Springer. 2007.

Ochs HD, Torgerson TR. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked inheritance: model for autoaggression. Adv Exp Med Biol. 2007;60:27-36.

Puck JM, SCID Newborn Screening Working Group (Torgerson TR, member). Population-based newborn screening for severe combined immunodeficiency: steps toward implementation. J Allergy Clin Immunol. Oct 2007;120(4):760-768.

Renner ED, Torgerson TR, Rylaarsdam S, Anover-Sombke S, Golob K, LaFlam T, Zhu Q, Ochs HD. STAT3 mutation in the original patient with Job's syndrome. N Engl J Med. Oct 2007;357(16):1667-1668.

Torgerson TR, Gambineri E, Ziegler SF, Ochs HD. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked inheritance. In: Ochs HD, Schmidt CE, Puck JM, eds. Primary Immunodeficiency Diseases: a Molecular and Genetic Approach, Second Edition. New York, N.Y.: Oxford University Press. 2007.

Torgerson TR, Linane A, Moes N, Anover S, Mateo V, Rieux-Laucat F, Hermine O, Vijay S, Gambineri E, Cerf-Bensussan N, Fischer A, Ochs HD, Goulet O, Ruemmele FM. Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene. Gastroenterology. May 2007;132(5):1705-1717.

Torgerson TR, Ochs HD. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells. J Allergy Clin Immunol. Oct 2007;120(4):744-750.

Torgerson TR, Ochs HD. Regulatory T cells in primary immunodeficiency diseases. Curr Opin Allergy Clin Immunol. Dec 2007;7(6):515-521.

Honors & Awards:

Seattle Metropolitan Magazine Top Doctor, 2008