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Sihoun Hahn, MD, PhD

Sihoun Hahn, MD, PhD

Sihoun Hahn, MD, PhD

Biochemical Genetics, Genetics

On staff since October 2006

Title:

Section Head, Biochemical Genetics

Academic Title:

Professor

Research Center:

Center for Developmental Therapeutics

Lab Information:

Visit my Lab Web Page

Offices & Contact Information

Location
Address
Contact
Seattle Children's

Primary office location

B-6594 - Biochemical Genetics

4800 Sand Point Way NE

Seattle, WA 98105

Primary Phone:

(206)987-3012

Professional History

Board Certified:

Clinical Biochemical Genetics
Clinical Genetics (MD)

Medical/Professional School:

Korea University College of Medicine, Seoul

Residency:

Korea University College of Medicine, Seoul, Pediatrics

Fellowship:

National Institute of Health, Bethesda, Medical Genetics

Clinical Interests:

Copper transport disorders

Mitochondrial disorders

Research Focus Area:

Biochemical Genetics
Genetics and Developmental Biology
Health Promotion and Disease Prevention

Description of Research:

Dr. Hahn's research has been focusing on copper metabolism, population screening for Wilson's disease and mitochondrial disease. His work focused on developing a newborn screening using tandem mass spectrometry for Wilson's disease, a genetic disease in which the body cannot excrete copper properly leading to its accumulation in various organs including the liver and brain. Dr. Hahn is developing an assay that quickly determines if the mitochondrial disease is present. Dr. Hahn hopes to improve clinical practice through integrated laboratory testing-true translational research.

Key Publications:

Ensenauer R, Winters JL, Parton PA, Kronn DF, Kim JW, Matern D, Rinaldo P, Hahn SH. Genotypic differences of MCAD deficiency in the Asian population: novel genotype and clinical symptoms preceding newborn screening notification. Genetics in Medicine 2005;7:339-343.

Kramer KA, Oglesbee D, Hartman SJ, Huey J, Anderson B, Magera MJ, Matern D, Rinaldo P, Robinson BH, Cameron JM, Hahn SH. Automated spectrophotometric analysis of mitochondrial respiratory chain complex enzyme activities in cultured skin fibroblasts. Clinical Chemistry 2005;51:2110-6

Oglesbee D, Freedenberg D, Kramer KA, Anderson BD, Hahn SH. Normal muscle respiratory chain enzymes can complicate mitochondrial disease diagnosis. Pediatric Neurology 2006 Oct;35(4):289-92

Kroll CA, Mensink K, Jacobson RM, Ferber M, Dawson B, Lorey F, Sherwin J, Cunningham G, Rinaldo P, Matern D, and Hahn SH. A retrospective determination of ceruloplasmin concentration in newborn dried blood spots from patients with Wilson disease. Molecular Genetics and Metabolism 2006 Oct;89:134-8.

Oglesbee D, He M, Majumder N, Vockley J, Ahmad A, Angle B, Burton B, Charrow J, Ensenauer R, Ficicioglu CH, Keppen LD, Marsden D, Tortorelli S, Hahn SH, Matern D. Development of a newborn screening follow-up algorithm for the diagnosis of isobutyryl-CoA dehydrogenase deficiency. Genetics in Medicine 2007 Feb;9(2):108-116.

Honors & Awards:

2009-2010 Luminex / American College of Medical Genetics Foundation (ACMGF) Award

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