Sidney M Gospe, MD, PhD

Professional History

Board Certified:

Neurology with Special Qualifications in Child Neu

Medical/Professional School:

Duke University, Durham
Duke University, Durham

Residency:

Baylor College of Medicine, Houston, Child NeurologyBaylor College of Medicine, Houston, Pediatrics

Clinical Interests:

Pediatric neuromuscular disease, neurotoxicology, pyridoxine-dependent seizures

Description of Research:

I am currently conducting research in two areas:

(1) the effects of maternal exposure to second hand tobacco smoke on the neurologic development of the fetus

(2) the clinical and genetic aspects of pyridoxine-dependent seizures

Key Publications:

Bennett, CL, Huynh, HM, Chance, PF, Glass, IA, Gospe, SM. Genetic Heterogeneity for Autosomal Recessive Pyridoxine-Dependent Seizures. Neurogenetics 6:143-149 (2005).

Gospe SM Jr: Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment, Curr Opin Neurol 19:148-153 (2006).

Bennett, CL, Chen, YZ, Hahn, SH, Glass, IA, Gospe SM Jr: Prevalence of ALDH7A1 mutations in 18 North American kindreds pyridoxine-dependent seizures (PDS) patients. Epilepsia (in press).

Basura, GJ, Hagland, SP, Wiltse, AM, Gospe SM Jr: Clinical features and management of pyridoxine-dependent and pyridoxine-responsive seizures: review of 63 North American cases submitted to a patient registry. Eur J Pediatr (in press).

Gospe, SM, Zhou, SS. , and Pinkerton, KE. 1996. Effects of environmental tobacco smoke exposure in utero and/or postnatally on brain development. Pediatric Research. 39:494-498.

Gospe, SM Jr, Joyce, JA, Siebert, JR, Jack, RM, Pinkerton, KE: Exposure to environmental tobacco smoke during pregnancy in rats yields less effects on indices of brain cell number and size than does postnatal exposure. Reproductive Toxiol 27:22-27 (2009).

Gospe, SM, Zhou, DB. , Saeed, DB. , and Zeman, FJ. 1996. Development of a rat model of toluene-abuse embryopathy. Pediatric Research. 40:82-87.

Gospe SM Jr; Zhou SS. 1998. Toluene abuse embryopathy: longitudinal neurodevelopmental effects of prenatal exposure to toluene in rats. Reproductive Toxicology. 12:119-26.

Gospe SM Jr, Zhou SS. 2000. Prenatal exposure to toluene results in abnormal neurogenesis and migration in rat somatosensory cortex. Pediatric Research. 47:362-8.

Honors & Awards:

Alpha Omega Alpha, elected as faculty member, 1993, University of California, Davis.

Faculty Teaching Award, 1991, 1992, 1993, 1999, University of California, Davis. Department of Pediatrics.

Faculty Teaching Award, 2006, 2008 University of Washington, Department of Neurology

Seattle Magazine Top Doc, 2004-06, 2008 Listed in Best Doctors in America, 4th Edition

Seattle Metropolitan Magazine Top Doctor, 2006-09