Paritosh C Khanna, MD

Professional History

Medical/Professional School:

K J Somaiya Medical College, Mumbai
L T M G Hospital - University of Mumbai, Mumbai, Radiology

Residency:

L T M G Hospital - University of Mumbai, Mumbai, Radiology

Fellowship:

Children's National Medical Center, Washington, Pediatric Radiology
University of Washington, Seattle, Neuroradiology

Clinical Interests:

Pediatric Neuroimaging
Pediatric Craniofacial and Head/Neck Imaging
Fetal Neuroimaging

Research Focus Area:

Imaging Science
Neuroscience / Neurodevelopment
Translational Research

Description of Research:

My research focuses on the application of imaging to the following:

1. Magnetic Resonance Imaging (MRI) of murine medulloblastoma (and other pediatric brain tumor) models in the evaluation of experimental drugs. It has been our goal to use MRI as the end-point for this evaluation and to minimize the use of experimental animals as a consequence. We have also successfully employed a 3 Tesla clinical MRI scanner to obtain substantially high-resolution MR images of juvenile mice. These scanners are generally more accessible than the higher field-strength research magnets and we have fined-tuned basic murine brain imaging sequences, protocols and parameters such that we can use this technique for investigation of murine models of most forms of pediatric (and adult) CNS disease. Various post-processing tools are being employed in the segmentation and volumetric analysis of the imaging data.

2. Craniofacial Imaging of craniosynostosis and craniofacial syndromes in collaboration with the Craniofacial Medicine team at Seattle Children's Hospital. Current research includes:
(a) Investigation of metopic synostosis
(b) To examine and correlate physical and Computed Tomography (CT) phenotypes and genotypes in patient groups with midface hypoplasia and associated sutural synostoses in non Crouzon's patients using CT in humans and micro-CT in animal models
(c) To define physical and CT phenotypes in Oculofrontonasal Syndrome (OAFNS)

3. MRI and Diffusion Tensor Imaging (DTI) and Tractography in the evaluation of trigeminal neuralgia as there is a lack of adequate imaging-clinical correlation using conventional MRI. The hope is that identification of normal and abnormal trigeminal nerve fibers from the nucleus through potentially the three divisions of the nerve may help identify the precise site of abnormality and assist in management of this condition.

Key Publications:

Khanna PC, Thapa MM. The growing skeleton: MR appearances of developing cartilage. MRI Clinics of North America 2009; 17 (3): 411-421.

Khanna PC, Thapa MM, de Regt D, Weinberger E. PACStacker: An enhancement of Scientific and Educational capabilities of Microsoft PowerPoint. AJR Am J Roentgenol 2009;192:W71-74.

Khanna PC, Godinho S, Patkar DP, Pungavkar SA, Lawande MA. Unusual Extra-Axial "Giant" Tuberculoma masquerading as a Meningioma: Diagnostic differentiation with Proton MR Spectroscopy. American Journal of Neuroradiology. 2006; 27(7):1438-40.

Lath CO, Khanna PC, Gadewar SB, Patkar DP. Intracranial Metastasis from Prostatic Adenocarcinoma simulating a Meningioma: A case report. Australasian Radiology. 2005; 49(6): 497-500.

Khanna PC, Pungavkar SA, Patkar DP. Ultrafast Magnetic Resonance Imaging of Cephalothoracopagus Janiceps Disymmetros. Journal of Postgraduate Medicine. 2005; 51(3): 228-229.

Khanna PC, Godinho S, Pungavkar SA, Patkar DP. Ultrafast MRI in the prenatal diagnosis of Bourneville?s Tuberous Sclerosis. Neurology India. 2005; 53(3): 349-350.

Khanna PC, Lath CO, Gadewar SB, Patkar DP. Role of Magnetic Resonance Perfusion studies in Moyamoya Disease. A case report. Neurology India. 2004; 52(2): 243-245. Listed on amazon.com by the Owlcroft English-Language site for English usage and grammar.

Gomez-Lobo V, Burch W, Khanna PC. Nonpuerperal uterine inversion associated with an immature teratoma of the uterus in an adolescent. Obstet Gynecol 2007; 110(2):491-3.

Khanna PC, Ponsky T, Zagol B, Lukish JR, Markle BM. Canal of Nuck hydrocele: Case report and spectrum of sonographic appearances. Pediatric Radiology 2007 37(6):603-606. Epub 2007 Apr 24.

Khanna PC, Rothenbach P, Guzzetta P, Bulas DI. Lap-belt Syndrome: Constellation of injuries in a 7-year-old. Pediatric Radiology. 2007; 37 (1):87-90. Epub 2006 Oct 21.