- Board Certified:
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Neurology with Special Qualifications in Child Neu
Pediatrics
- Medical/Professional School:
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University of Utah School of Medicine, Salt Lake City
- Residency:
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Columbia Presbyterian Hospital, New York, Pediatrics
Neurological Institute, New York, Child Neurology
- Clinical Interests:
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Movement disorders, cortical and cerebellar dysgenesis, toxicology, drug addiction and withdrawal
- Research Focus Area:
Neuroscience / Neurodevelopment
- Description of Research:
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The Bamford laboratory studies synaptic function and regulation of presynaptic activity. Presently, we are concentrating on the effects of dopamine on corticostriatal projections. In particular, we are interested in how dopamine depletion, Huntington's disease and psychostimulant withdrawal affect the release of glutamate from cortical projections to the striatum.
- Key Publications:
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Bamford NS*, Zhang H, Schmitz Y, Wu N-P, Cepeda C, Levine MS, Schmauss C, Zakharenko SS, Zablow L, Sulzer D (2004) Heterosynaptic Dopamine Neurotransmission Selects Sets of Corticostriatal Terminals. Neuron. 42:653-63. See Comment in Neuron 2004. 42:522-4.
Bamford NS*, Robinson S, Palmiter, RD, Joyce JA, Moore, C. Meshul, CK (2004) Dopamine Modulates Release from Corticostriatal Terminals. J Neurosci. 24, 9541-52.
Bamford NS*, Zhang H, Joyce JA, Scarlis CA, Hanan W, Wu N-P, Andre VM, Cohen R, Cepeda C, Levine MS, Harleton E, Sulzer D (2008) Repeated methamphetamine causes long-lasting presynaptic corticostriatal depression that is renormalized with drug readministration. Neuron. 58 (1): 89-103. See Comments on this research in Neuron 2008. 58:6-7 and in Nature Reviews Neuroscience 2008. 9:409.
Bamford NS*, Robinett SA, Otto RK, Gospe SM. (2009) Neuromuscular Hip Dysplasia in Charcot Marie Tooth Disease Type 1A. Developmental Medicine and Child Neurology. 51(5):408-11.
Joshi PR, Wu N-P, Andre VM, Cummings D, Cepeda C, Joyce JA, Carroll JB, Leavitt BR, Hayden MR, Levine MS, Bamford NS*. (2009) Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington Disease. J. Neurosci. 29(8):2414-2427.
- Honors & Awards:
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Child Neurology Society Young Investigator Award 2002