- Medical/Professional School:
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University of Cincinnati College of Medicine, Cincinnati
- Fellowship:
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Case Western Reserve University, Cleveland, Cardiology
- Clinical Interests:
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Cell metabolism, biomedicine, MRI
- Description of Research:
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We also perform research in Kawasaki Disease, which is an inflammatory syndrome attacking coronary arteries in children. Our work includes drug studies in animal models, and pharmacogenomic studies in patients. We are also performing clincial trials in patients.
We study cardiac metabolism and the impact of changing substrate utilization on the heart during development and during pathological states such as heart failure and cardiopulmonary bypass. Thyroid regulation of metabolism is a primary interest. Work is translational and progresses from basic benchtop studies to mice to large animals to the bedside.
- Key Publications:
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Portman MA, Qian K, Krueger J, Ning XH. T3 Directly Modifies Phosphorylation Potential in sheep heart in vivo Am J Physiol Heart Circ Physio 288(5):H2484-90
The cardioselective and dominant negative thyroid hormone receptor ({Delta}337T) modulates myocardial substrate metabolism and contractile efficiency.Hyyti OM, Olson A, Ge M, Ning XH, Buroker NE, Chung Y, Jue T, Portman MA. Am J Physiol Endocrinol Metab (June 3, 2008). doi:10.1152/ajpendo.90329.2008
Ning XH, Hyyti OM, Anderson DL and Portman MA. Rapid Progressive Central Cooling To 29 ?C By Extracorporeal Circuit Preserves Cardiac Function And Hemodynamics In Immature Swine. Resuscitation 76:443-448, 2008
Ning, X-H, Buroker NE, Chen S-H, Xu, C-S, Li, F Li SP, Song D-S, Hyyti, OM, Zhang M, Portman MA Hypoxia Inducible Factor-1a Responds to Short Cycle Hypoxia in the Intact Heart. Am J Physiol Heart Circ Physiol. Jan 2007;292(1):H333-341.
Portman MA, Fearneyhough C, Karl T, Tong E, Mott A, Cohen G, Tacy T, Lewin M, Permut L, Pignatelli R, Schlater M, Azakie A. The Triidothyronine for infants and Children undergoing Cardiopulmonary Bypass (TRICC) Study: Design and Rationale American Heart Journal. 148:393-8, 2004.
- Honors & Awards:
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National Research Service award, Young Investigator award
Young Investigator award