- Board Certified:
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Pediatric Infectious Diseases
- Medical/Professional School:
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University of Kansas, Lawrence
- Residency:
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UCLA School of Medicine, Los Angeles, Pediatrics
- Clinical Interests:
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Prevention and treatment of pediatric HIV disease, research ethics
- Description of Research:
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My lab's research focuses on practical questions related to the prevention of HIV-1 infection in infants, mechanisms leading to shedding of virus in adults and treatment of drug-resistant virus in children and adults. Several projects evaluate the selection and dynamics of drug-resistant HIV-1 mutants during antiretroviral therapy (ART) and as a result of peripartum chemoprophylaxis given to women and infants.
Our group is also keenly interested in the implementation of interventions to prevent mother-to-child-transmission in resource-strapped communities, and understanding the mechanisms that cause some adults but not others to shed HIV-1 from their, in their breast milk or from their genital tract. In addition, we aim to develop and transfer practical and economical assays for HIV-1 detection in infants, and for monitoring treatment and drug-resistant mutants in these communities.
Our projects include collaborative studies with colleagues in India, Kenya, Mozambique, Peru, Thailand, the USA and Zimbabwe.
- Key Publications:
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Frenkel LM, Mullins JI. Should patients with drug-resistant HIV-1 continue to receive antiretroviral therapy? (editorial) N Engl J Med. 2001;344:520-2.
Beck IA, Mahalanabis M, Pepper G, Wright A, Hamilton S, Langston E, Frenkel LM. A rapid and sensitive oligonucleotide ligation assay for the detection of mutations in human immunodeficiency virus type 1 associated with high-level resistance to protease inhibitors. J Clin Microbiol. 2002;40: 1413-9.
Frenkel LM, Wang Y, Learn GH, Melvin AJ, Ellis GM, McKernan JL, De Vange SM, Mohan KM, Holte S, Sylva GL, Naugler WE, Mahalanabis M, Beck IA, Lewis PA, Heath LM, Tobin NH, Pawluk D, Mullins JI. Multiple Viral Genetic Analyses Detect Low-level Human Immunodeficiency Virus type-1 Replication During Effective HAART. J Virol. 2003;77:5721-30.
Li CC, Beck IA, Seidel KD, Frenkel LM. Persistence of Human Immunodeficiency Virus Type 1 Subtype B DNA in Dried Blood Samples on FTA? Filter Paper. J Clin Microbiol. 2004;42:3847-9.
Ellis GM, Mahalanabis M, Beck IA, Pepper G, Wright A, Hamilton S, Holte S, Naugler WE, Pawluk DM, Li CC, Frenkel LM. Comparison of Oligonucleotide Ligation Assay and Consensus Sequencing for Detection of Drug-Resistant Mutants of Human Immunodeficiency Virus Type 1 in Peripheral Blood Mononuclear Cells and Plasma. J Clin Microbiol. 2004; 42:3670-4.
- Honors & Awards:
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Council-member, University Relations