Lawrence Corey, MD

Professional History

Board Certified:

Internal Medicine

Research Focus Area:

Virology

Description of Research:

My research areas include studies of the immunobiology of HSV, infection and vaccine development for HSV-2, HIV, infections in the bone marrow transplant patient, and the interactions between HSV-2 and HIV-1. My major laboratory program involves understanding host responses that influence HSV reactivation and acquisition, with the ultimate goal of developing an effective HSV vaccine. The clinical program in genital herpes includes studies looking at the natural history of subclinical shedding, the transmission of HSV to sexual partners and infants, and the relationship between the host response and viral reactivation of infection. My laboratory also specializes in the detection of antigen specific T cells in mucosal tissues.

I direct a molecular diagnostic laboratory studying novel viral infections, especially in immunocompromised patients. One area of focus is the relationship between viral infection and mortality and graft rejection in transplant patients. Studies examining the relationship between Kaposi?s sarcoma and the acquisition, transmission, and effect of viral replication of HHV-8 are also underway. These studies are performed in collaboration with Dr. Corey Casper and are largely based at the Uganda Cancer Center in Kampala, Uganda.

I am the PI of the NIAID-supported HIV Vaccine Trials Network (HVTN). This is a multi-center, international program for developing and testing candidate HIV vaccines that includes Phase I through Phase III studies.

Key Publications:

Abu-Raddad LJ, Magaret AS, Celum C, Wald A, Longini IM, Self SG, Corey L. Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa. PLoS ONE 2008;3(5):1-15.

Casper C, Krantz EM, Corey L, Kuntz SR, Wang J, Selke S, Hamilton S, Huang ML, Wald A. Valganciclovir for suppression of human herpesvirus 8 replication: a randomized, double-blind, placebo-controlled, crossover trial. J Infect Dis 2008;198:23-30.

Johnston C, Magaret A, Selke S, Remington M, Corey L, Wald A. Herpes simplex virus viremia during primary genital infection. J Infect Dis 2008;198:31-4.

Celum C, Wald A, Hughes J, Sanchez J, Reid S, Delaney-Moretlwe S, Cowan F, Casapia M, Ortiz A, Fuchs J, Buchbinder S, Koblin B, Zwerski S, Rose S, Wang J, Corey L, and HPTN 039 Protocol Team. Effect of acyclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomized, double-blind, placebo-controlled trial. Lancet 2008;371:2109-19.

Morgan C, Marthas M, Miller C, Duerr A, Cheng-Mayer C, Desrosiers R, Flores J, Haigwood N, Hu SL, Johnson RP, Lifson J, Montefiori D, Moore J, Robert-Guroff M, Robinson H, Self S, Corey L. The use of nonhuman primate models in HIV vaccine development. PLoS Med 2008;5(8):e173.

Honors & Awards:

1984: Recipient, Achievement Award, American Venereal Disease Association

1997: Recipient, Thomas Parran Award, American Society for STD Research

1998: Recipient, Pan American Society Clinical Virology Award

2000: Recipient, John D. Enders Distinguished Lectureship Award, Infectious Diseases Society of America

2001: Recipient, MERIT Award, Cytotoxic T Cell Reservoirs to HSV among HIV-Infected Persons (Renewed 2007)