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On staff since July 2006
Center for Clinical and Translational Research
Primary office location
B-6553 - Hematology-Oncology
4800 Sand Point Way NE
Seattle, WA 98105
(206)987-2380
FHCRC Box 358080 - MS D2-373
PO Box 19024
Seattle, WA 98109-1024
(206) 667-4886
Pediatric Hematology-OncologyPediatrics
Columbia University College of Physicians and Surgery, New York
University of Washington, Seattle, Pediatrics
Fred Hutchinson Cancer Research Center, Seattle, Pediatric Hematology-Oncology
Cancer
My research interests include the biology of acute myeloid leukemia (AML) and the impact of disease biology on clinical response. At present, I am better defining the maturational states of hematopoietic precursors in which molecular events contributing to leukemogenesis arise, and have demonstrated that pediatric AML patients with an internal tandem duplication of the FLT3 gene do poorly if the mutation is detected in an immature hematopoietic progenitor population. My ultimate goal is to improve clinical outcomes in AML by enhancing understanding of the biologic events that contribute to leukemogenesis and by determining whether heterogeneity of such events affects clinical response to conventional chemotherapeutics and/or targeted agents like gemtuzumab ozogamicin (GO). I am also exploring methods for enhancing GO efficacy in patients with GO-resistant disease.
Pollard JA, Alonzo TA, Gerbing RB, Woods WG, Lange BJ, Sweetser DA, Radich JP, Bernstein ID, Meshinchi S. FLT3 internal tandem duplication in CD34+/CD33- precursors predicts poor outcome in acute myeloid leukemia. Blood. 2006;108:2764-2769 (Abstract) Pollard J, Alonzo T, Gerbing R, Raimondi S, Hirsch B, Franklin J, Gamis A, Loken M and Meshinchi S. Correlation of CD 33 Expression Level with Disease Characteristics and Response to Gemtuzumab Ozogamicin Containing Chemotherapy in Childhood AML. Blood 112 (11): 148a (Abstract) Pollard J, Alonzo T, Gerbing R, Zeng R, Hirsch B, Raimondi S, Heerema N, Woods W, Lange B, Hurwitz C, Arceci R, Radich J, Bernstein I, Heinrich M, Meshinchi S. Prevalence and prognostic significance of c-KIT mutations in pediatric CBF AML patients enrolled on serial CCG/COG protocols. Blood 2007;110(11):1442a.
2007: NIH Career Development Award (K Award) Winner 2008 - Present: CureSearch Research Fellowship Award 2008 - Present: For Julie Foundation Research Award 2008 - Present: St. Baldrick's Foundation, Career Development Award
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