Holly K Tabor, PhD

Professional History

Research Focus Area:

Behavioral / Mental Health

Description of Research:

I conduct research on ethical issues in genetic research on complex traits, particularly complex traits in children. Current projects include research on causal models in genetic research on autism and the interactions between researchers and advocacy groups in genetic research on complex traits, focusing on the field of autism and characterizing the perspectives of parents and adolescents across different contexts of pediatric genetic research about ethical and social issues, including parental permission and informed consent, return of results to families, sharing of samples and data, the meanings of genetic data and the potential benefits and risk. In addition, I am collaborating with researchers at the Center for Clinical Genomics to proactively identify and address ethical and social issues in ongoing complex disease research.

Key Publications:

Margolis KL, Ensrud KE, Schreiner PJ, Tabor HK. Body size and risk for clinical fractures in older women. Study of Osteoporotic Fractures Research Group. Annals of Internal Medicine. 2000 Jul 18; 133(2) 123-7.

Schwartz AV, Sellmeyer DE, Ensrud KE, Cauley JA, Tabor HK, Schreiner PJ, Jamal SA, Black DM, Cummings SR. Older women with diabetes have an increased risk of fracture: a prospective study. Journal of Clinical Endocrinology and Metabolism 2001 Jan; 86(1):32-8.

Chrischilles EA, Dasbach EJ, Rubenstein LM, Cook JR, Tabor HK, Black DM. The effect of alendronate on fracture-related healthcare utilization and costs: the fracture intervention trial. Osteoporosis International 2001; 12(8)654-60.

Li J, Tabor HK, Nguyen L, Gleason C, Lotspeich LJ, Spiker D, Risch N, Myers RM. Lack of association between HoxA1 and HoxB1 gene variants and autism in 110 multiplex autism families. American Journal of Medical Genetics 2002 Jan 8; 114(1):24- 30.

Tabor HK, Risch NJ, Myers RM. Candidate-gene approaches for studying the genetics of complex traits: practical approaches. Nature Reviews Genetics 2002 May; 3(5):391-7.

Tabor HK, Cho MK. Ethical implications of array comparative genomic hybridization in complex phenotypes: points to consider in research. Genetics in Medicine 2007 Sep; 9(9):626-31.

Assimes, TL, Knowles JW, Priest JR, Basu A, Borchert A, Volcik KA, Grove ML, Tabor HK, Southwick A, Tabibizar R, Sidney S, Boerwinkle E, Go AS, Iribarren C, Hlatkly MA, Fortmann SP, Myers RM, Kuhn H, Risch N, Quertermous T. A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease. Atherosclerosis 2007 Oct(22), Epub ahead of print.

Hlatky MA, Quertermous T, Boothroyd DB, Priest JR, Glassford AJ, Myers RM, Fortmann SP, Iribarren C, Tabor HK, Assimes TL, Tibshirini RJ, Go AS. Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease. American Heart Journal 2007 Dec; 154(6):1035-42