- Medical/Professional School:
-
University of North Carolina at Chapel Hill School of Medicine, Chapel Hill
- Residency:
-
University of California - San Francisco, San Francisco, Pediatrics
- Fellowship:
-
Children's Hospital of Los Angeles - Pediatric Residency, Los Angeles, Pediatric RheumatologyNational Institute of Health, Rockville, Infectious DiseaseUCLA School of Medicine, Los Angeles
- Description of Research:
-
My primary research interests include altered lymphoid B cell development and signaling leading to immunodeficiency, autoimmunity or lymphoid malignancies, and the development of gene therapy for primary immune deficiency diseases. My laboratory uses expertise in basic and clinical immunology, signal transduction and lymphocyte developmental biology to understand how altered signals can lead to immunologic disease, with the ultimate goal of developing translational therapies capable of specifically modulating these disorders.
I am a member of multiple regional and national organizations, an NIH study section member, chairman for the USIDNET XLA patient registry, and ad hoc reviewer for various grant programs and immunology journals. I also co-direct the Northwest Genome Engineering Consortium, a research program funded as part of the NIH Roadmap focused on developing enzymatic reagents and delivery methods for site specific gene repair in hematopoietic stem cells. Northwest Genome Engineering Consortium (NGEC), http://research.seattlechildrens.org/ngec.
The Immunology research laboratories carry out basic, pre-clinical and clinical research. Primary immunodeficiency disorders (PIDD) represent some of the best candidate disorders for treatment via hematopoietic stem cell gene therapy, and our translational research programs include modeling of novel gene and cellular therapies. Our clinical program also participates in novel clinical trials for non myeloablative hematopoietic stem cell transplant in PIDD.
- Key Publications:
-
Rawlings DJ, Saffran DC, Tsukada S, Largaespada DA, Grimaldi JC, Cohen L, Mohr RN, Bazan JF, Howard M, Copeland NG, Jenkins NA and Witte ON: Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. (1993) Science 261:358-361.
Yu PW, Tabuchi RS, Kato RM, Astrakhan A, Humblet-Baron S, Kipp K, Chae K, Ellmeier W, Witte ON, Rawlings DJ. Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer. (2004) Blood 104(5):1281-1290.
Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-Garcia ME, Ovechkina YL, Rawlings DJ. Phosphorylation of the CARMA1 Linker Controls NF-?B Activation. (2005) Immunity 23 (6): 561-574.
Rawlings DJ, Sommer K, Moreno-Garc?a ME. The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes. (2006) Nat Rev Immunol 6(11):799-812.
Humblet-Baron S, Sather B, Anover S, Becker-Herman S, Kasprowicz DJ, Khim S, Nguyen T, Hudkins-Loya K, Alpers CE, Ziegler SF, Ochs H, Torgerson T, Campbell DJ, Rawlings DJ. Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis. (2007) J Clin Invest. 1;117(2):407-418.
- Honors & Awards:
-
Elected to Association of American Physicians
Seattle Children's Guild Association Endowed Chair in Pediatric Immunology