- Board Certified:
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Pediatric Infectious Diseases
- Medical/Professional School:
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Vanderbilt University School of Medicine, Nashville
- Residency:
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University of Washington School of Medicine, Seattle, Pediatrics
- Fellowship:
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Centers for Disease Control and Prevention, Atlanta, Infectious DiseaseUniversity of Washington School of Medicine, Seattle, Infectious Disease
- Description of Research:
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My research focuses on factors that influence the acquisition of respiratory virus infection and disease progression among immunocompromised children and adults, with the goal to facilitate new diagnostic, preventive, and treatment strategies for respiratory virus infections.
I am currently focused on the study of parainfluenza viruses (PIVs), ubiquitous respiratory viruses that are second only to respiratory syncytial virus (RSV) as important viral causes of lower respiratory infection in children and immunocompromised patients. Unlike RSV, there are no specific antiviral therapies to prevent or treat PIVs. These viruses are important sources of morbidity and mortality in adult and pediatric immunocompromised patients, especially hematopoietic cell transplant (HCT) recipients. Among HCT recipients, PIVs are the most common serious respiratory viruses, with high rates of pneumonia and increased risk of mortality even with upper respiratory tract disease alone. The spectrum of PIV infection can range from asymptomatic infection to pneumonia and death in the HCT population. Prolonged viral shedding, increased risk of long-term airflow obstruction, and high rates of nosocomial transmission accompany PIV infection in HCT recipients.
My current studies will be important to document rates of asymptomatic PIV infection in a large cohort of HCT recipients, to determine if asymptomatic infection leads to progression of respiratory disease, to clearly define the presence of persistent subclinical shedding, and to analyze whether humoral immunity is protective against symptomatic infection or disease progression.
- Key Publications:
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Vu, Debie, * Peck AJ *, Nichols WG, Varley C, Englund JA, Corey L, Boeckh M. Safety and Tolerability of Oseltamivir Prophylaxis in Hematopoietic Stem Cell Transplantation Recipients: A Retrospective Case-Control Study (*contributed equally). Clin Infect Dis, 2007;45:187-93.
Peck AJ, Englund JA, Kuypers J, Corey L, Morrow R, Cent A, Boeckh M. Respiratory Virus Infection among Hematopoietic Cell Transplantation Recipients: Evidence for Asymptomatic Parainfluenza Virus Infection. Blood, 2007;110:1681-88.
Gutman JA, Peck AJ, Kuypers J, Boeckh M. Rhinovirus as a cause of fatal lower respiratory tract infection in adult stem cell transplantation patients: A report of two cases. Bone Marrow Transplant, 2007:40:809-11
Nichols WG, Peck Campbell AJ, Boeckh, M. Respiratory Viruses Other than Influenza Virus: Impact and Therapeutic Advances. Clin Microbiol Rev, 2008:21(2),274-90.
- Honors & Awards:
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2008: Joint Meeting Program Committee Award in the area of Clinical Microbiology and Diagnosis, 2008 ICAAC/IDSA Annual Meeting - one of 6 awards to recognize research excellence through outstanding abstract preparation.