Allison A Eddy, MD

Professional History

Board Certified:

Pediatric Nephrology
Pediatrics

Medical/Professional School:

McMaster University, Hamilton

Residency:

McGill University, Montreal, Pediatrics

Fellowship:

University of Minnesota Medical School, Minneapolis, Pediatric Nephrology

Clinical Interests:

Progressive kidney disease, glomerulonephritis, interstitial nephritis

Research Focus Area:

Tissue Response to Injury

Description of Research:

Mechanisms of inflammation and fibrosis in progressive kidney disease. Our current studies are focused on the role of scavenger receptors and the family of serine proteases and their inhibitors.

Key Publications:

Oda T, Jung YO, Kim H, Cai X, Lopez-Guisa J, Ikeda Y, Eddy AA. PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction. Kidney Int, 2001;60:587-596.

Eddy AA. Plasminogen activator inhibitor-1 and the kidney. Am J Physiol. 2002;283: F209-F220.

Zhang G, Kim H, Cai S, Lopez-Guisa J, Carmeliet P, Eddy AA: The urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy. J Am Soc Nephrol. 2003;14:1234-1253.

Zhang G, Kim H, Cai X, Lopez-Guisa J, Alpers CE, Liu Y, Carmeliet P, Eddy AA: Urokinase receptor deficiency accelerates renal fibrosis in obstructive uropathy. J Am Soc Nephrol. 2004;14:1254-1271.

Zhang G, Cai X, L?pez-Guisa JM, Collins SL, Eddy AA: Mitogenic Signaling of uPAR-Deficient Kidney Fibroblasts: Actions of an Alternative Urokinase Receptor and LDL Receptor-Related Protein. J Am Soc Nephrol. In press.

Honors & Awards:

Seattle Metropolitan Magazine Top Doctor, 2006-08