- Medical/Professional School:
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McMaster University, Hamilton
- Residency:
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McGill University, Montreal, Pediatrics
- Fellowship:
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University of Minnesota Medical School, Minneapolis, Pediatric Nephrology
- Clinical Interests:
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Progressive kidney disease, Glomerulonephritis, interstitial nephritis
- Description of Research:
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Mechanisms of inflammation and fibrosis in progressive kidney disease. Our current studies are focused on the role of scavenger receptors and the family of serine proteases and their inhibitors.
- Key Publications:
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Oda T, Jung YO, Kim H, Cai X, Lopez-Guisa J, Ikeda Y, Eddy AA. PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction. Kidney Int, 2001;60:587-596.
Eddy AA. Plasminogen activator inhibitor-1 and the kidney. Am J Physiol. 2002;283: F209-F220.
Zhang G, Kim H, Cai S, Lopez-Guisa J, Carmeliet P, Eddy AA: The urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy. J Am Soc Nephrol. 2003;14:1234-1253.
Zhang G, Kim H, Cai X, Lopez-Guisa J, Alpers CE, Liu Y, Carmeliet P, Eddy AA: Urokinase receptor deficiency accelerates renal fibrosis in obstructive uropathy. J Am Soc Nephrol. 2004;14:1254-1271.
Zhang G, Cai X, L?pez-Guisa JM, Collins SL, Eddy AA: Mitogenic Signaling of uPAR-Deficient Kidney Fibroblasts: Actions of an Alternative Urokinase Receptor and LDL Receptor-Related Protein. J Am Soc Nephrol. In press.
- Honors & Awards:
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Seattle Metropolitan Magazine Top Doctor, 2006-08