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On staff since July 2007
Center for Clinical and Translational Research
Primary office location
FHCRC Box 358080 - MS D2-373
PO Box 19024
Seattle, WA 98109-1024
(206) 667-4886
B-6553 - Hematology-Oncology
4800 Sand Point Way NE
Seattle, WA 98105
(206)987-2380
Pediatric Hematology-Oncology
University of Rochester School of Medicine, RochesterJohns Hopkins University School of Medicine, Baltimore
Johns Hopkins University School of Medicine, Baltimore, Pediatrics
Boston Children's Hospital, Boston, Pediatric Hematology-Oncology
Inherited bone marrow failure syndromes and aplastic anemia Shwachman-Diamond syndrome, Fanconi anemia and Diamond Blackfan anemia
Blood DisordersCancer
My research interests focus on hematopoiesis and leukemogenesis in the inherited marrow failure syndrome. My current studies investigate the role of ribosomal dysfunction in marrow failure and malignant transformation. I am also pursuing studies on translational control of gene expression in hematopoietic stem cells. Recent laboratory findings reported a role for mitotic spindle stabilization in genomic instability. I am a member of the scientific advisory board for the Shwachman-Diamond Syndrome Foundation and served as co-chair of the Fourth International Scientific Congress on Shwachman-Diamond Syndrome. I am also the principal investigator for the North American Shwachman-Diamond Syndrome Registry currently under development.
Cantor AB, Shimamura A. Cellular basis of hematopoiesis and marrow failure syndromes. In: Kahn MJ, Gregory SA, eds. American Society of Hematology Self-Assessment Program (ASH-SAP), Third Edition. Washington, D.C.: American Society of Hematology. 2007. Ganapathi KA, Austin KM, Lee CS, Dias A, Malsch MM, Reed R, Shimamura A. The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA. Blood. Sept 2007;110(5):1458?1465. Kennedy RD, Chen CC, Stuckert P, Archila EM, De la Vega MA, Moreau L, Shimamura A, D'Andrea AD. Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest. May 2007;117(5):1440?1449.
Seattle Metropolitan Magazine Top Doctor, 2008 2007: NIH Career Development Award (K Award) Winner
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