- Board Certified:
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Pediatric Hematology-Oncology
- Medical/Professional School:
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University of Rochester School of Medicine, Rochester
Johns Hopkins University School of Medicine, Baltimore
- Residency:
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Johns Hopkins University School of Medicine, Baltimore, Pediatrics
- Fellowship:
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Boston Children's Hospital, Boston, Pediatric Hematology-Oncology
- Clinical Interests:
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Inherited bone marrow failure syndromes and aplastic anemia
Shwachman-Diamond syndrome, Fanconi anemia and Diamond Blackfan anemia
- Description of Research:
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My research interests focus on hematopoiesis and leukemogenesis in the inherited marrow failure syndrome. My current studies investigate the role of ribosomal dysfunction in marrow failure and malignant transformation. I am also pursuing studies on translational control of gene expression in hematopoietic stem cells. Recent laboratory findings reported a role for mitotic spindle stabilization in genomic instability. I am a member of the scientific advisory board for the Shwachman-Diamond Syndrome Foundation and served as co-chair of the Fourth International Scientific Congress on Shwachman-Diamond Syndrome. I am also the principal investigator for the North American Shwachman-Diamond Syndrome Registry currently under development.
- Key Publications:
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Cantor AB, Shimamura A. Cellular basis of hematopoiesis and marrow failure syndromes. In: Kahn MJ, Gregory SA, eds. American Society of Hematology Self-Assessment Program (ASH-SAP), Third Edition. Washington, D.C.: American Society of Hematology. 2007.
Ganapathi KA, Austin KM, Lee CS, Dias A, Malsch MM, Reed R, Shimamura A. The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA. Blood. Sept 2007;110(5):1458?1465.
Kennedy RD, Chen CC, Stuckert P, Archila EM, De la Vega MA, Moreau L, Shimamura A, D'Andrea AD. Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest. May 2007;117(5):1440?1449.
- Honors & Awards:
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Seattle Metropolitan Magazine Top Doctor, 2008
2007: NIH Career Development Award (K Award) Winner