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Akiko Shimamura, MD, PhD

Akiko Shimamura, MD, PhD

Akiko Shimamura, MD, PhD

Hematology-Oncology

On staff since July 2007

Research Center:

Center for Clinical and Translational Research

Offices & Contact Information

Location
Address
Contact
Fred Hutchinson Cancer Research Center

Primary office location

FHCRC Box 358080 - MS D2-373

PO Box 19024

Seattle, WA 98109-1024

Primary Phone:

(206) 667-4886

Seattle Children's

B-6553 - Hematology-Oncology

4800 Sand Point Way NE

Seattle, WA 98105

Primary Phone:

(206)987-2380

Professional History

Board Certified:

Pediatric Hematology-Oncology

Medical/Professional School:

University of Rochester School of Medicine, Rochester
Johns Hopkins University School of Medicine, Baltimore

Residency:

Johns Hopkins University School of Medicine, Baltimore, Pediatrics

Fellowship:

Boston Children's Hospital, Boston, Pediatric Hematology-Oncology

Clinical Interests:

Inherited bone marrow failure syndromes and aplastic anemia

Shwachman-Diamond syndrome, Fanconi anemia and Diamond Blackfan anemia

Research Focus Area:

Blood Disorders
Cancer

Description of Research:

My research interests focus on hematopoiesis and leukemogenesis in the inherited marrow failure syndrome. My current studies investigate the role of ribosomal dysfunction in marrow failure and malignant transformation. I am also pursuing studies on translational control of gene expression in hematopoietic stem cells. Recent laboratory findings reported a role for mitotic spindle stabilization in genomic instability. I am a member of the scientific advisory board for the Shwachman-Diamond Syndrome Foundation and served as co-chair of the Fourth International Scientific Congress on Shwachman-Diamond Syndrome. I am also the principal investigator for the North American Shwachman-Diamond Syndrome Registry currently under development.

Key Publications:

Cantor AB, Shimamura A. Cellular basis of hematopoiesis and marrow failure syndromes. In: Kahn MJ, Gregory SA, eds. American Society of Hematology Self-Assessment Program (ASH-SAP), Third Edition. Washington, D.C.: American Society of Hematology. 2007.

Ganapathi KA, Austin KM, Lee CS, Dias A, Malsch MM, Reed R, Shimamura A. The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA. Blood. Sept 2007;110(5):1458?1465.

Kennedy RD, Chen CC, Stuckert P, Archila EM, De la Vega MA, Moreau L, Shimamura A, D'Andrea AD. Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest. May 2007;117(5):1440?1449.

Honors & Awards:

Seattle Metropolitan Magazine Top Doctor, 2008

2007: NIH Career Development Award (K Award) Winner

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