Profile

Troy R. Torgerson, MD, PhD

Troy R. Torgerson, MD, PhD

Immunology

On staff since August 2004

Academic Title: Associate Professor

Research Center: Center for Immunity and Immunotherapies

"I am passionate about closing loops. This starts in clinic, with patients who put their trust in our ability to help them identify and deal with severe, chronic and often inherited diseases of the immune system. It then moves to the lab, where we make every effort to understand each patients disease at the molecular and genetic level. It proceeds to our research labs, where we work to circumvent or correct the molecular defects that we find. The loop closes as we take what we have learned back to the clinic, to more effectively treat or cure disease. My challenge is to find ways to close these loops more quickly and efficiently in order to provide hope for patients and families."

Troy R. Torgerson, MD, PhD, is attending physician at Seattle Childrens Hospital and assistant professor in the Department of Pediatrics at the University of Washington School of Medicine. He is co-director of the Immunology Diagnostic Laboratory within the Center for Immunity and Immunotherapies at Seattle Childrens Research Institute.

He obtained his MD and PhD from Vanderbilt University School of Medicine and completed residency training in pediatrics and a fellowship in pediatric rheumatology and immunology at the University of Washington. He participates in clinical care of patients with immune deficiency and autoimmune disorders at Seattle Childrens and coordinates care for patients treated by hematopoietic stem cell transplant (HSCT). He coordinates several joint clinical research protocols designed to optimize HSCT treatment in PIDD. Dr. Torgersons clinical interests include the diagnosis and management of children and adults with primary immunodeficiency diseases (PIDDs) and children with autoimmune disorders. His bench research focuses on the identification of basic cellular mechanisms that promote both autoimmunity and immunodeficiency. His research laboratory studies the molecular basis of disease in two immunodeficiency disorders; Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) syndrome and Hyper-IgE syndrome. The genetic defects that cause these clinical syndromes alter the development of immune cells that either control immune responses (IPEX syndrome) or promote inflammation (Hyper-IgE syndrome).

Making A Difference

  • Nailing Difficult Diagnoses

    Our Immunology Diagnostic Laboratory develops tests – and makes difficult diagnoses – that help children with immune disorders lead longer, healthier lives. ... cont.

Recommendations

  • Samanatha Boise, Idaho 07.18.14

    Dr. Torgerson is personable, obviously cares about the children he works with, and was one of the best things about being at Seattle Children's Hospital. I would recommend him a thousand times if I could. He was the only reason we chose Seattle Children's for our son's care for IPEX syndrome, and is the only reason we would ever consider going back.

Overview

Board Certification(s)

Pediatrics
Pediatric Rheumatology

Medical/Professional School

Vanderbilt University School of Medicine, Nashville

Residency

Pediatrics, University of Washington School of Medicine, Seattle

Fellowship

Pediatric Rheumatology, University of Washington School of Medicine, Seattle

Research Description

I am co-director of the Immunodeficiency Molecular Diagnostics Laboratory.

My research interests relate to the identification of basic cellular mechanisms that jointly promote autoimmunity and immunodeficiency. My research is focused on studies of the molecular basis of immune dysregulation present in patients with immune dysregulation, polyendocrinopathy,enteropathy, X-linked (IPEX). The genetic defect present in this syndrome alters the development and function of regulatory T cells, which are required for controlling immune responses. I am a member of the Society for Pediatric Research and coordinate several joint clinical research protocols designed to optimize HSCT treatment in PIDD.

I also participate in the clinical care of patients with immune deficiency and autoimmune disorders at Seattle Children's Hospital and coordinate care for immunodeficient patients treated by hematopoietic stem cell transplant (HSCT). My clinical interests include the diagnosis and management of children and adults with primary immunodeficiency diseases (PIDDs) and autoimmune disorders in children.

Research Focus Area

Immunology

Publications

  • Cabral-Marques O, Klaver S, Schimke LF, Ascendino EH, Khan TA, Pereira PV, Falcai A, Vargas-Hernández A, Santos-Argumedo L, Bezrodnik L, Moreira I, Seminario G, Di Giovanni D, Raccio AG, Porras O, Weber CW, Ferreira JF, Tavares FS, de Carvalho E, Valente CF, Kuntze G, Galicchio M, King A, Rosário-Filho NA, Grota MB, Dos Santos Vilela MM, Di Gesu RS, Lima S, de Souza Moura L, Talesnik E, Mansour E, Roxo-Junior P, Aldave JC, Goudouris E, Pinto-Mariz F, Berrón-Ruiz L, Staines-Boone T, Calderón WO, Del Carmen Zarate-Hernández M, Grumach AS, Sorensen R, Durandy A, Torgerson TR, Carvalho BT, Espinosa-Rosales F, Ochs HD, Condino-Neto A
    First Report of the Hyper-IgM Syndrome Registry of the Latin American Society for Immunodeficiencies: Novel Mutations, Unique Infections, and Outcomes.
    Journal of clinical immunology , 2014 Jan. 9
  • Hulse KE, Chaung K, Seshadri S, Suh L, Norton JE, Carter RG, Kern RC, Conley DB, Chandra RK, Tan BK, Peters AT, Grammer LC 3rd, Harris KE, Torgerson TR, Kato A, Schleimer RP
    Suppressor of cytokine signaling 3 expression is diminished in sinonasal tissues from patients with chronic rhinosinusitis with nasal polyps.
    The Journal of allergy and clinical immunology , 2014 Jan. : 133(1)275-277.e1
  • Griffith LM, Cowan MJ, Notarangelo LD, Kohn DB, Puck JM, Pai SY, Ballard B, Bauer SC, Bleesing JJ, Boyle M, Brower A, Buckley RH, van der Burg M, Burroughs LM, Candotti F, Cant AJ, Chatila T, Cunningham-Rundles C, Dinauer MC, Dvorak CC, Filipovich AH, Fleisher TA, Bobby Gaspar H, Gungor T, Haddad E, Hovermale E, Huang F, Hurley A, Hurley M, Iyengar S, Kang EM, Logan BR, Long-Boyle JR, Malech HL, McGhee SA, Modell F, Modell V, Ochs HD, O'Reilly RJ, Parkman R, Rawlings DJ, Routes JM, Shearer WT, Small TN, Smith H, Sullivan KE, Szabolcs P, Thrasher A, Torgerson TR, Veys P, Weinberg K, Zuniga-Pflucker JC, on behalf of the workshop participants
    Primary Immune Deficiency Treatment Consortium (PIDTC) report.
    The Journal of allergy and clinical immunology , 2013 Oct. 15
  • Boonyawat B, Dhanraj S, Al Abbas F, Zlateska B, Grunenbaum E, Roifman CM, Steele L, Meyn S, Blanchette V, Scherer SW, Swierczek S, Prchal J, Zhu Q, Torgerson TR, Ochs HD, Dror Y
    Combined de-novo mutation and non-random X-chromosome inactivation causing Wiskott-Aldrich syndrome in a female with thrombocytopenia.
    Journal of clinical immunology , 2013 Oct. : 33(7)1150-5
  • Schimke LF, Rieber N, Rylaarsdam S, Cabral-Marques O, Hubbard N, Puel A, Kallmann L, Sombke SA, Notheis G, Schwarz HP, Kammer B, Hökfelt T, Repp R, Picard C, Casanova JL, Belohradsky BH, Albert MH, Ochs HD, Renner ED, Torgerson TR
    A novel gain-of-function IKBA mutation underlies ectodermal dysplasia with immunodeficiency and polyendocrinopathy.
    Journal of clinical immunology , 2013 Aug. : 33(6)1088-99
  • Allenspach EJ, Bellodi C, Jeong D, Kopmar N, Nakamura T, Ochs HD, Ruggero D, Skoda-Smith S, Shimamura A, Torgerson TR
    Common variable immunodeficiency as the initial presentation of dyskeratosis congenita.
    The Journal of allergy and clinical immunology , 2013 July : 132(1)223-6
  • Kroll JL, Beam C, Li S, Viscidi R, Dighero B, Cho A, Boulware D, Pescovitz M, Weinberg A, Type 1 Diabetes TrialNet Anti CD-20 Study Group
    Reactivation of latent viruses in individuals receiving rituximab for new onset type 1 diabetes.
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology , 2013 June : 57(2)115-9
  • Uzel G, Sampaio EP, Lawrence MG, Hsu AP, Hackett M, Dorsey MJ, Noel RJ, Verbsky JW, Freeman AF, Janssen E, Bonilla FA, Pechacek J, Chandrasekaran P, Browne SK, Agharahimi A, Gharib AM, Mannurita SC, Yim JJ, Gambineri E, Torgerson T, Tran DQ, Milner JD, Holland SM
    Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like syndrome.
    The Journal of allergy and clinical immunology , 2013 June : 131(6)1611-23
  • Mohiuddin MS, Abbott JK, Hubbard N, Torgerson TR, Ochs HD, Gelfand EW
    Diagnosis and evaluation of primary panhypogammaglobulinemia: a molecular and genetic challenge.
    The Journal of allergy and clinical immunology , 2013 June : 131(6)1717-8
  • Mizesko MC, Banerjee PP, Monaco-Shawver L, Mace EM, Bernal WE, Sawalle-Belohradsky J, Belohradsky BH, Heinz V, Freeman AF, Sullivan KE, Holland SM, Torgerson TR, Al-Herz W, Chou J, Hanson IC, Albert MH, Geha RS, Renner ED, Orange JS
    Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency.
    The Journal of allergy and clinical immunology , 2013 Mar. : 131(3)840-8
  • Kinnunen T, Chamberlain N, Morbach H, Choi J, Kim S, Craft J, Mayer L, Cancrini C, Passerini L, Bacchetta R, Ochs HD, Torgerson TR, Meffre E
    Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells.
    Blood , 2013 Feb. 28 : 121(9)1595-603
  • Torgerson TR
    Comparing routes of IgG administration for primary immunodeficiency disorders.
    Journal of clinical immunology , 2013 Jan. : 33 Suppl 2S85-6
  • Torgerson TR
    Overview of routes of IgG administration.
    Journal of clinical immunology , 2013 Jan. : 33 Suppl 2S87-9
  • Torgerson TR, Bonagura VR, Shapiro RS
    Clinical ambiguities--ongoing questions.
    Journal of clinical immunology , 2013 Jan. : 33 Suppl 2S99-103
  • Burnside K, Lembo A, Harrell MI, Klein JA, Lopez-Guisa J, Siegesmund AM, Torgerson TR, Oukka M, Molina DM, Rajagopal L
    Vaccination with a UV-irradiated genetically attenuated mutant of Staphylococcus aureus provides protection against subsequent systemic infection.
    The Journal of infectious diseases , 2012 Dec. 1 : 206(11)1734-44
  • Kerfoot SA, Jung S, Golob K, Torgerson TR, Hahn SH
    Tryptic peptide screening for primary immunodeficiency disease by LC/MS-MS.
    Proteomics. Clinical applications , 2012 Aug. : 6(7-8)394-402
  • d'Hennezel E, Bin Dhuban K, Torgerson T, Piccirillo CA
    The immunogenetics of immune dysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome.
    Journal of medical genetics , 2012 May : 49(5)291-302
  • Torgerson TR
    Immunodeficiency diseases with rheumatic manifestations.
    Pediatric clinics of North America , 2012 Apr, : 59(2)493-507
  • Cabral-Marques O, Schimke LF, Pereira PV, Falcai A, de Oliveira JB, Hackett MJ, Errante PR, Weber CW, Ferreira JF, Kuntze G, Rosário-Filho NA, Ochs HD, Torgerson TR, Carvalho BT, Condino-Neto A
    Expanding the clinical and genetic spectrum of human CD40L deficiency: the occurrence of paracoccidioidomycosis and other unusual infections in Brazilian patients.
    Journal of clinical immunology , 2012 Apr, : 32(2)212-20
  • Cabral-Marques O, Arslanian C, Ramos RN, Morato M, Schimke L, Soeiro Pereira PV, Jancar S, Ferreira JF, Weber CW, Kuntze G, Rosario-Filho NA, Costa Carvalho BT, Bergami-Santos PC, Hackett MJ, Ochs HD, Torgerson TR, Barbuto JA, Condino-Neto A
    Dendritic cells from X-linked hyper-IgM patients present impaired responses to Candida albicans and Paracoccidioides brasiliensis.
    The Journal of allergy and clinical immunology , 2012 Mar. : 129(3)778-86
  • Meyer-Bahlburg A, Renner ED, Rylaarsdam S, Reichenbach J, Schimke LF, Marks A, Tcheurekdjian H, Hostoffer R, Brahmandam A, Torgerson TR, Belohradsky BH, Rawlings DJ, Ochs HD
    Heterozygous signal transducer and activator of transcription 3 mutations in hyper-IgE syndrome result in altered B-cell maturation.
    The Journal of allergy and clinical immunology , 2012 Feb. : 129(2)559-62, 562.e1-2
  • Meyer-Bahlburg A, Renner ED, Rylaarsdam S, Reichenbach J, Schimke LF, Marks A, Tcheurekdjian H, Hostoffer R, Brahmandam A, Torgerson TR, Belohradsky BH, Rawlings DJ, Ochs HD
    Heterozygous signal transducer and activator of transcription 3 mutations in hyper-IgE syndrome result in altered B-cell maturation.
    The Journal of allergy and clinical immunology , 2012 Feb. : 129(2)559-562.e2
  • Gambineri E, Torgerson TR
    Genetic disorders with immune dysregulation.
    Cellular and molecular life sciences : CMLS , 2012 Jan. : 69(1)49-58
  • Bunin N, Small T, Szabolcs P, Baker KS, Pulsipher MA, Torgerson T
    NCI, NHLBI/PBMTC first international conference on late effects after pediatric hematopoietic cell transplantation: persistent immune deficiency in pediatric transplant survivors.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2012 Jan. : 18(1)6-15
  • Lundgren IS, Englund JA, Burroughs LM, Torgerson TR, Skoda-Smith S
    Outcomes and duration of Pneumocystis jiroveci pneumonia therapy in infants with severe combined immunodeficiency.
    The Pediatric infectious disease journal , 2012 Jan. : 31(1)95-7
  • Gambineri E, Torgerson TR
    Genetic disorders with immune dysregulation.
    Cellular and molecular life sciences : CMLS , 2012 Jan. : 69(1)49-58
  • López SI, Ciocca M, Oleastro M, Cuarterolo ML, Rocca A, de Dávila MT, Roy A, Fernández MC, Nievas E, Bosaleh A, Torgerson TR, Ruiz JA
    Autoimmune hepatitis type 2 in a child with IPEX syndrome.
    Journal of pediatric gastroenterology and nutrition , 2011 Dec. : 53(6)690-3
  • Pescovitz MD, Torgerson TR, Ochs HD, Ocheltree E, McGee P, Krause-Steinrauf H, Lachin JM, Canniff J, Greenbaum C, Herold KC, Skyler JS, Weinberg A, Type 1 Diabetes TrialNet Study Group
    Effect of rituximab on human in vivo antibody immune responses.
    The Journal of allergy and clinical immunology , 2011 Dec. : 128(6)1295-1302.e5
  • López SI, Ciocca M, Oleastro M, Cuarterolo ML, Rocca A, de Dávila MT, Roy A, Fernández MC, Nievas E, Bosaleh A, Torgerson TR, Ruiz JA
    Autoimmune hepatitis type 2 in a child with IPEX syndrome.
    Journal of pediatric gastroenterology and nutrition , 2011 Dec. : 53(6)690-3
  • Pescovitz MD, Torgerson TR, Ochs HD, Ocheltree E, McGee P, Krause-Steinrauf H, Lachin JM, Canniff J, Greenbaum C, Herold KC, Skyler JS, Weinberg A, Type 1 Diabetes TrialNet Study Group
    Effect of rituximab on human invivo antibody immune responses.
    The Journal of allergy and clinical immunology , 2011 Dec. : 128(6)1295-1302.e5
  • Marques OC, Arslanian C, Ramos RN, Morato M, Schimke L, Soeiro Pereira PV, Jancar S, Ferreira JF, Weber CW, Kuntze G, Rosario-Filho NA, Costa Carvalho BT, Bergami-Santos PC, Hackett MJ, Ochs HD, Torgerson TR, Marzagão Barbuto JA, Condino-Neto A
    Dendritic cells from X-linked hyper-IgM patients present impaired responses to Candida albicans and Paracoccidioides brasiliensis.
    The Journal of allergy and clinical immunology , 2011 Dec.
  • Cabral-Marques O, Schimke LF, Pereira PV, Falcai A, de Oliveira JB, Hackett MJ, Errante PR, Weber CW, Ferreira JF, Kuntze G, Rosário-Filho NA, Ochs HD, Torgerson TR, Carvalho BT, Condino-Neto A
    Expanding the Clinical and Genetic Spectrum of Human CD40L Deficiency: The Occurrence of Paracoccidioidomycosis and Other Unusual Infections in Brazilian Patients.
    Journal of clinical immunology , 2011 Dec.
  • Moratto D, Giliani S, Bonfim C, Mazzolari E, Fischer A, Ochs HD, Cant AJ, Thrasher AJ, Cowan MJ, Albert MH, Small T, Pai SY, Haddad E, Lisa A, Hambleton S, Slatter M, Cavazzana-Calvo M, Mahlaoui N, Picard C, Torgerson TR, Burroughs L, Koliski A, Neto JZ, Porta F, Qasim W, Veys P, Kavanau K, Hönig M, Schulz A, Friedrich W, Notarangelo LD
    Long-term outcome and lineage-specific chimerism in 194 patients with Wiskott-Aldrich syndrome treated by hematopoietic cell transplantation in the period 1980-2009: an international collaborative study.
    Blood , 2011 Aug. 11 : 118(6)1675-84
  • Moratto D, Giliani S, Bonfim C, Mazzolari E, Fischer A, Ochs HD, Cant AJ, Thrasher AJ, Cowan MJ, Albert MH, Small T, Pai SY, Haddad E, Lisa A, Hambleton S, Slatter M, Cavazzana-Calvo M, Mahlaoui N, Picard C, Torgerson TR, Burroughs L, Koliski A, Neto JZ, Porta F, Qasim W, Veys P, Kavanau K, Hönig M, Schulz A, Friedrich W, Notarangelo LD
    Long-term outcome and lineage-specific chimerism in 194 patients with Wiskott-Aldrich syndrome treated by hematopoietic cell transplantation in the period 1980-2009: an international collaborative study.
    Blood , 2011 Aug. : 118(6)1675-84
  • Tsuda M, Torgerson TR, Selmi C, Gambineri E, Carneiro-Sampaio M, Mannurita SC, Leung PS, Norman GL, Gershwin ME
    The spectrum of autoantibodies in IPEX syndrome is broad and includes anti-mitochondrial autoantibodies.
    Journal of autoimmunity , 2010 Nov. : 35(3)265-8
  • Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders J, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD, Woolfrey AE
    Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
    The Journal of allergy and clinical immunology , 2010 Nov. : 126(5)1000-5
  • Tsuda M, Torgerson TR, Selmi C, Gambineri E, Carneiro-Sampaio M, Mannurita SC, Leung PS, Norman GL, Gershwin ME
    The spectrum of autoantibodies in IPEX syndrome is broad and includes anti-mitochondrial autoantibodies.
    Journal of autoimmunity , 2010 Nov. : 35(3)265-8
  • Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders J, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD, Woolfrey AE
    Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
    The Journal of allergy and clinical immunology , 2010 Nov. : 126(5)1000-5
  • Ardoin SP, Schanberg LE, Sandborg C, Yow E, Barnhart HX, Mieszkalski Kl, Ilowite NT, von Scheven E, Eberhard A, Levy DM, Kimura Y, Silverman E, Bowyer SL, Punaro L, Singer NG, Sherry DD, McCurdy D, Klein-Gitelman M, Wallace C, Silver R, Wagner-Weiner L, Higgins GC, Brunner HI, Jung LK, Imundo L, Soep JB, Reed AM, APPLE investigators
    Laboratory markers of cardiovascular risk in pediatric SLE: the APPLE baseline cohort.
    Lupus , 2010 Oct. : 19(11)1315-25
  • Schimke LF, Sawalle-Belohradsky J, Roesler J, Wollenberg A, Rack A, Borte M, Rieber N, Cremer R, Maass E, Dopfer R, Reichenbach J, Wahn V, Hoenig M, Jansson AF, Roesen-Wolff A, Schaub B, Seger R, Hill HR, Ochs HD, Torgerson TR, Belohradsky BH, Renner ED
    Diagnostic approach to the hyper-IgE syndromes: immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis.
    The Journal of allergy and clinical immunology , 2010 Sept. : 126(3)611-7.e1
  • Wang HY, Gopalan V, Aksentijevich I, Yeager M, Ma CA, Mohamoud YA, Quinones M, Matthews C, Boland J, Niemela JE, Torgerson TR, Giliani S, Uzel G, Orange JS, Shapiro R, Notarangelo L, Ochs HD, Fleisher T, Kastner D, Chanock SJ, Jain A
    A custom 148 gene-based resequencing chip and the SNP explorer software: new tools to study antibody deficiency.
    Human mutation , 2010 Sept. : 31(9)1080-8
  • Schimke LF, Sawalle-Belohradsky J, Roesler J, Wollenberg A, Rack A, Borte M, Rieber N, Cremer R, Maass E, Dopfer R, Reichenbach J, Wahn V, Hoenig M, Jansson AF, Roesen-Wolff A, Schaub B, Seger R, Hill HR, Ochs HD, Torgerson TR, Belohradsky BH, Renner ED
    Diagnostic approach to the hyper-IgE syndromes: immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis.
    The Journal of allergy and clinical immunology , 2010 Sept. : 611-7.e1
  • Quan PL, Wagner TA, Briese T, Torgerson TR, Hornig M, Tashmukhamedova A, Firth C, Palacios G, Baisre-De-Leon A, Paddock CD, Hutchison SK, Egholm M, Zaki SR, Goldman JE, Ochs HD, Lipkin WI
    Astrovirus encephalitis in boy with X-linked agammaglobulinemia.
    Emerging infectious diseases , 2010 June : 16(6)918-25
  • Huter EN, Natarajan K, Torgerson TR, Glass DD, Shevach EM
    Autoantibodies in scurfy mice and IPEX patients recognize keratin 14.
    The Journal of investigative dermatology , 2010 May : 130(5)1391-9
  • Skoda-Smith S, Torgerson TR, Ochs HD
    Subcutaneous immunoglobulin replacement therapy in the treatment of patients with primary immunodeficiency disease.
    Therapeutics and clinical risk management , 2010 Feb. : 61-10
  • Gruenberg DA, Añover-Sombke S, Gern JE, Holland SM, Rosenzweig SD, Torgerson TR, Seroogy CM
    Atypical presentation of IL-12 receptor beta1 deficiency with pneumococcal sepsis and disseminated nontuberculous mycobacterial infection in a 19-month-old girl born to nonconsanguineous US residents.
    The Journal of allergy and clinical immunology , 2010 Jan. : 125(1)264-5
  • Griffith LM, Cowan MJ, Notarangelo LD, Puck JM, Buckley RH, Candotti F, Conley ME, Fleisher TA, Gaspar HB, Kohn DB, Ochs HD, O'Reilly RJ, Rizzo JD, Roifman CM, Small TN, Shearer WT, Workshop Participants
    Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.
    The Journal of allergy and clinical immunology , 2009 Dec. : 124(6)1152-60.e12
  • Miao CH, Harmeling BR, Ziegler SF, Yen BC, Torgerson T, Chen L, Yau RJ, Peng B, Thompson AR, Ochs HD, Rawlings DJ
    CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice.
    Blood , 2009 Nov. 5 : 114(19)4034-44
  • d'Hennezel E, Ben-Shoshan M, Ochs HD, Torgerson TR, Russell LJ, Lejtenyi C, Noya FJ, Jabado N, Mazer B, Piccirillo CA
    FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome.
    The New England journal of medicine , 2009 Oct. : 1710-3
  • Renner ED, Hartl D, Rylaarsdam S, Young ML, Monaco-Shawver L, Kleiner G, Markert ML, Stiehm ER, Belohradsky BH, Upton MP, Torgerson TR, Orange JS, Ochs HD
    Coml-Netherton syndrome defined as primary immunodeficiency.
    The Journal of allergy and clinical immunology , 2009 Sept. : 124(3)536-43
  • Torgerson TR, Genin A, Chen C, Zhang M, Zhou B, Añover-Sombke S, Frank MB, Dozmorov I, Ocheltree E, Kulmala P, Centola M, Ochs HD, Wells AD, Cron RQ
    FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression.
    Journal of immunology (Baltimore, Md. : 1950) , 2009 July : 183(2)907-15
  • Ochs HD, Oukka M, Torgerson TR
    TH17 cells and regulatory T cells in primary immunodeficiency diseases.
    The Journal of allergy and clinical immunology , 2009 May : 123(5)977-83; quiz 984-5
  • Liu P, Santisteban I, Burroughs LM, Ochs HD, Torgerson TR, Hershfield MS, Rawlings DJ, Scharenberg AM
    Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.
    Clinical immunology (Orlando, Fla.) , 2009 Feb. : 130(2)162-74
  • Schultz KA, Neglia JP, Smith AR, Ochs HD, Torgerson TR, Kumar A
    Familial hemophagocytic lymphohistiocytosis in two brothers with X-linked agammaglobulinemia.
    Pediatric blood & cancer , 2008 Aug. : 51(2)293-5
  • Renner ED, Rylaarsdam S, Anover-Sombke S, Rack AL, Reichenbach J, Carey JC, Zhu Q, Jansson AF, Barboza J, Schimke LF, Leppert MF, Getz MM, Seger RA, Hill HR, Belohradsky BH, Torgerson TR, Ochs HD
    Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome.
    The Journal of allergy and clinical immunology , 2008 July : 122(1)181-7
  • Ringold S, Torgerson TR, Egbert MA, Wallace CA
    Intraarticular corticosteroid injections of the temporomandibular joint in juvenile idiopathic arthritis.
    The Journal of rheumatology , 2008 June : 35(6)1157-64
  • Torgerson TR
    Immune dysregulation in primary immunodeficiency disorders.
    Immunology and allergy clinics of North America , 2008 May : 28(2)315-27, viii-ix
  • Torgerson TR
    Immune dysregulation in primary immunodeficiency disorders.
    Immunology and allergy clinics of North America , 2008 May : 315-27, viii-ix
  • Yoo J, Wolgamot G, Torgerson TR, Sidbury R
    Cutaneous noncaseating granulomas associated with Nijmegen breakage syndrome.
    Archives of dermatology , 2008 Mar. : 418-9
  • Torgerson TR, Ochs HD
    Regulatory T cells in primary immunodeficiency diseases.
    Current opinion in allergy and clinical immunology , 2007 Dec. : 7(6)515-21
  • Torgerson TR, Ochs HD
    Regulatory T cells in primary immunodeficiency diseases.
    Current opinion in allergy and clinical immunology , 2007 Dec. : 515-21
  • Renner ED, Torgerson TR, Rylaarsdam S, Añover-Sombke S, Golob K, LaFlam T, Zhu Q, Ochs HD
    STAT3 mutation in the original patient with Job's syndrome.
    The New England journal of medicine , 2007 Oct. 18 : 357(16)1667-8
  • Renner ED, Torgerson TR, Rylaarsdam S, Añover-Sombke S, Golob K, LaFlam T, Zhu Q, Ochs HD
    STAT3 mutation in the original patient with Job's syndrome.
    The New England journal of medicine , 2007 Oct. 18 : 1667-8
  • Torgerson TR, Ochs HD
    Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells.
    The Journal of allergy and clinical immunology , 2007 Oct. : 120(4)744-50; quiz 751-2
  • Torgerson TR, Ochs HD
    Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells.
    The Journal of allergy and clinical immunology , 2007 Oct. : 744-50; quiz 751-2
  • Torgerson TR, Linane A, Moes N, Anover S, Mateo V, Rieux-Laucat F, Hermine O, Vijay S, Gambineri E, Cerf-Bensussan N, Fischer A, Ochs HD, Goulet O, Ruemmele FM
    Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene.
    Gastroenterology , 2007 May : 1705-17
  • Heltzer ML, Choi JK, Ochs HD, Sullivan KE, Torgerson TR, Ernst LM
    A potential screening tool for IPEX syndrome.
    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society , 2007 Mar. : 10(2)98-105
  • Humblet-Baron S, Sather B, Anover S, Becker-Herman S, Kasprowicz DJ, Khim S, Nguyen T, Hudkins-Loya K, Alpers CE, Ziegler SF, Ochs H, Torgerson T, Campbell DJ, Rawlings DJ
    Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.
    The Journal of clinical investigation , 2007 Feb. : 117(2)407-18
  • Ochs HD, Gambineri E, Torgerson TR
    IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity.
    Immunologic research , 2007 : 38(1-3)112-21
  • Ochs HD, Torgerson TR
    Immune dysregulation, polyendocrinopathy, enteropathy, X-linked inheritance: model for autoaggression.
    Advances in experimental medicine and biology , 2007 : 60127-36
  • Ochs HD, Torgerson TR
    Immune dysregulation, polyendocrinopathy, enteropathy, X-linked inheritance: model for autoaggression.
    Advances in experimental medicine and biology , 2007 : 27-36
  • Ochs HD, Gambineri E, Torgerson TR
    IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity.
    Immunologic research , 2007 : 112-21
  • Lopes JE, Torgerson TR, Schubert LA, Anover SD, Ocheltree EL, Ochs HD, Ziegler SF
    Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor.
    Journal of immunology (Baltimore, Md. : 1950) , 2006 Sept. 1 : 177(5)3133-42
  • Torgerson TR
    Regulatory T cells in human autoimmune diseases.
    Springer seminars in immunopathology , 2006 Aug. : 28(1)63-76
  • Gavin MA, Torgerson TR, Houston E, DeRoos P, Ho WY, Stray-Pedersen A, Ocheltree EL, Greenberg PD, Ochs HD, Rudensky AY
    Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development.
    Proceedings of the National Academy of Sciences of the United States of America , 2006 Apr, 25 : 103(17)6659-64
  • Lee WI, Torgerson TR, Schumacher MJ, Yel L, Zhu Q, Ochs HD
    Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome.
    Blood , 2005 Mar. : 105(5)1881-90
  • Ochs HD, Ziegler SF, Torgerson TR
    FOXP3 acts as a rheostat of the immune response.
    Immunological reviews , 2005 Feb. : 203156-64
  • Ochs HD, Ziegler SF, Torgerson TR
    FOXP3 acts as a rheostat of the immune response.
    Immunological reviews , 2005 Feb. : 156-64
  • Gambineri E, Torgerson TR, Ochs HD
    Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis.
    Current opinion in rheumatology , 2003 July : 15(4)430-5
  • Torgerson TR, Ochs HD
    Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: a model of immune dysregulation.
    Current opinion in allergy and clinical immunology , 2002 Dec. : 2(6)481-7
  • Hannibal MC, Torgerson T, Pagon RA, Bird TD, Dolan CR, Stephens K
    IPEX Syndrome
  • Scharenberg AM, Hannibal MC, Torgerson T, Ochs HD, Rawlings DJ, Pagon RA, Bird TD, Dolan CR, Stephens K
    Common Variable Immune Deficiency Overview
  • Yu LS, Versteeg F, Kinoshita M, Yuan B, Bishop N, Torgerson T, Topaz S, Kolff WJ
    Soft artificial ventricles for infants and adults, with or without a clamshell.
    ASAIO transactions / American Society for Artificial Internal Organs , 1990 July : 36(3)M238-42

Presentations

Presentations Title Event Location Date
IPEX 44. American Autoimmune Related Diseases Association Scientific Colloquium Baltimore, MD Jan. 1, 2009
Insights into FOXP3 and STAT3 transcription factor biology from human disease 43. Stanford University Immunology Program Seminar Series Palo Alto, CA Jan. 1, 2009
New mutations affecting innate immunity 42. American College of Rheumatology Annual Meeting Philadelphia, PA Jan. 1, 2009
Immunology dysregulation, polyendocrinopathy, enteropathy, x-linked and forkhead box P3 41. American College of Rheumatology Annual Meeting Philadelphia, PA Jan. 1, 2009
New tricks from old transcription factors: FOXP3 and STAT3 in human Immunodeficiency disorders 40. Duke University Medical Center Immunology Seminar Series Durham, NC Jan. 1, 2009
The association between autoimmunity and immunodeficiency disorders-tragic stories of indifference and disloyalty 39. Duke University Medical Center Pediatric Grand Rounds Durham, NC Jan. 1, 2009
Immune dysregulation syndromes: single gene defects associated with severe autoimmunity 38. 5th Annual Sudhir Gupta Endowed Chair in Molecular Immunology Symposium Newport Beach, CA Jan. 1, 2009
Immunology 101 & Treatment Options for PIDD 37. Immune Deficiency Foundation Lake Buena Vista, FL Jan. 1, 2009
Basic Immunology 36. Immune Deficiency Foundation Lake Buena Vista, FL Jan. 1, 2009
The naturally occurring splice variant of FOXP3 lacking Exon 2 is not sufficient to maintain immune homeostasis and prevent IPEX in vivo in humans. 35. Federation of Clinical Immunology Societies San Francisco, CA Jan. 1, 2009
Functional consequences of FOXP3 and STAT3 mutations identified in IPEX and Hyper IgE syndrome. Northwestern University Feinberg School of Medicine Chicago, IL Jan. 1, 2009
Recent scientific advances to promote early diagnosis of PID: current issues and potential solutions. Latin American Symposium Sao Paulo, Brazil Jan. 1, 2009
Our daily war on terror: how the immune System protects our bodies from invaders and a look at interesting ways in which this breaks down. Idaho State University Pocatello, ID Jan. 1, 2009
Failure of immune tolerance. 31. American Academy of Allergy, Asthma & Immunology, Annual Meeting Washington, D.C. Jan. 1, 2009
When less is more: the conundrum of autoimmunity in immunodeficiency syndromes. 30. Immune Deficiency Foundation, Le Bien Visiting Professor Program Hershey, PA Jan. 1, 2009

Research Funding

Grant Title Grantor Amount Award Date
Developmental and Genetic Defects of Immunity NIH/NICHD $228,926 March 1, 2004 - Aug. 31, 2010