Dr. Suzanne Skoda Smith | Seattle Children's Hospital

Suzanne Skoda-Smith, MD

On staff since August 2008

Academic Title: Associate Professor, Assistant Program Director of the UWSOM Allergy and Immunology Fellowship Training Program

Research Center: Center for Immunity and Immunotherapies

"I was on my way home from a conference when I heard my name shouted out. I turned to discover the parents of a young boy I had done a bone marrow transplant on for severe combined immunodeficiency disease several years earlier. His parents were security agents, working the late shift at the airport. I remembered they had lost their young daughter to the same disease. After a gigantic bear hug from both of them, I got to see their son’s Little League picture and learned that he is a talented skateboarder as well. I flew home feeling that what I have learned as an immunologist was put to good use."

Suzanne Skoda-Smith, MD, is attending physician at Seattle Children’s Hospital and associate professor in the Department of Pediatrics at the University of Washington School of Medicine. She is clinical director for the Division of Immunology at Seattle Children’s Hospital and associate director of the University of Washington Allergy and Immunology Fellowship Training Program.

She received her undergraduate degree in immunology at University of California at Berkeley, attended University of Miami School of Medicine, completed residency at University of Florida, and received her fellowship training at the University of Alabama at Birmingham. Her focus is on translational therapies for primary immunodeficiency, including hematopoetic cell transplantation, gene therapy and improved supportive care. Dr. Skoda-Smith is a member of the Non-Malignant Transplant Board which is held jointly with members of the Seattle Cancer Care Alliance and Fred Hutchinson Cancer Research Center. As a member of the Center for Immunity and Immunotherapies, as well as the American Society of Gene and Cell Therapy, she participates in clinical trials dedicated to improving treatment for people with primary immune deficiency.

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Overview
Awards and Honors
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Overview

Board Certification(s): Pediatrics
Allergy and Immunology
Medical/Professional School: University of Miami - Jackson Memorial Medical Center, Miami
Residency: University of Florida, Gainsville, Pediatrics
Fellowship: Children's Hospital of Alabama, Birmingham, Allergy and Immunology
Clinical Interests: Primary Immunodeficiency Diseases, Hematopoetic Stem Cell Transplantation for Immunodeficiency, Secondary Immunodeficiency associated with Solid Organ Transplantation Clinical care for patients with primary immunodeficiencies
Research Description: My clinical research has been focused on the delivery of care and new therapies to patients with primary immunodeficiency diseases, particularly those needing hematopoetic stem cell transplantation. I am particularly interested in how to bring the promise of new therapies currently in the laboratory setting, to reality in the clinical care arena. I also interface with clinicians skilled in the care of solid organ transplant patients who experience secondary immunodeficiency as a consequence of their transplant therapies.
Research Focus Area: Translational Research, Solid Organ Transplantation, Stem Cell Transplantation

Awards and Honors

Award Name	Awarded By	Award Date
K30, Masters Candidate in the Advanced Postgraduate Program in Clinical Investigation	University of Florida	2000 - 2001
Dixon Post-Doctorate Fellowship		1995 - 1997
National Research Service Award (NRSA) Training Grant	University of Alabama at Birmingham	1994 - 1995
AΩA		1990
Medical School Trustee Scholarship	Univeristy of Miami	1986 - 1990

Publications

Outcomes and Duration of Pneumocystis jiroveci Pneumonia Therapy in Infants With Severe Combined Immunodeficiency.
The Pediatric infectious disease journal , 2011 Aug 3:

Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
The Journal of allergy and clinical immunology , 2010 Jul 17:

Subcutaneous immunoglobulin replacement therapy in the treatment of patients with primary immunodeficiency disease.
Therapeutics and clinical risk management , 2010 Feb 2: 1-10

Persistent perianal abscess in early infancy as a presentation of autoimmune neutropenia.
Journal of perinatology : official journal of the California Perinatal Association , 2003 Jul-Aug: 428-30

Pharmacokinetics and tolerability of a new intravenous immunoglobulin preparation, IGIV-C, 10% (Gamunex, 10%).
Vox sanguinis , 2003 Apr: 202-10

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.
Nature , 2002 Sep 26: 395-9

Anti-CD20 monoclonal antibody (rituximab) therapy for acute cardiac humoral rejection: a case report.
Transplantation , 2002 Mar 27: 907-10

Treatment of post-transplant lymphoproliferative disease with induction chemotherapy followed by haploidentical peripheral blood stem cell transplantation and Rituximab.
Bone marrow transplantation , 2001 Feb: 329-32

Donor leukocyte infusions after bone marrow transplantation in children: series from a single institution and review of the literature.
International Journal of Pediatric Hematology/Oncology 7 , 2001: 71-79

Current management in child neurology
Vasculitis , 2001:

Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70.
Journal of immunology (Baltimore, Md. : 1950) , 2001 Jan 1: 656-61

Failure of combined costimulatory blockade in animal transplant model.
Nature medicine , 2000 Feb: 115

Thalidomide in children undergoing bone marrow transplantation: series at a single institution and review of the literature.
Pediatrics , 1999 Apr: e44

Alpha 1-antitrypsin deficiency in a child with X-linked lymphoproliferative disease.
Archives of pathology & laboratory medicine , 1997 Sep: 996-9

CD4+ memory T cells are the predominant population of HIV-1-infected lymphocytes in neonates and children.
AIDS (London, England) , 1996 Nov: 1477-84

Presentations

Presentations Title	Event	Location	Date
Identifying Primary Immunodeficiencies: Present and Future	Legacy Continuing Medical Education: Current Topics in Pediatrics Conference	Portland, OR	Nov. 19, 2011
Parent Education Meeting for Persons and Families Living with Primary Immunodeficiency Diseases	Immune Deficiency Foundation	Seattle, WA	Sept. 10, 2011
RASopathies and Other Shard Conditions	Hematology/Oncology Friday AM Research Conference	Seattle, WA	2011
Primary Immunodeficiency for the Hematologist/OncologistPrimary Immunodeficiency for the Hematologist-Oncologist	Research Seminar, Seattle Children’s Hospital	Seattle, WA	Sept. 1, 2009
Non-Malignant Review Board Presentation	Seattle Cancer Care Alliance	Seattle, WA	Sept. 1, 2009
Severe Combined Immunodeficiency Disease	Advanced Oncology Day, Seattle Children’s Hospital	Seattle, WA	Jan. 1, 2009

Research Funding

Grant Title	Grantor	Amount	Award Date
Lentiviral Gene Therapy of X-linked Agammaglobulinemia	NIH/NIAID	$, $	Sept. 23, 2009
Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome	NIH/NIAID	$, $	March 1, 2008 - Feb. 28, 2013

Suzanne Skoda-Smith, MD

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