Profile

Suzanne Skoda-Smith, MD

Suzanne Skoda-Smith, MD

Immunology

On staff since August 2008

Academic Title: Associate Professor, Assistant Program Director of the UWSOM Allergy and Immunology Fellowship Training Program

Research Center: Center for Immunity and Immunotherapies

"I was on my way home from a conference when I heard my name shouted out. I turned to discover the parents of a young boy I had done a bone marrow transplant on for severe combined immunodeficiency disease several years earlier. His parents were security agents, working the late shift at the airport. I remembered they had lost their young daughter to the same disease. After a gigantic bear hug from both of them, I got to see their sons Little League picture and learned that he is a talented skateboarder as well. I flew home feeling that what I have learned as an immunologist was put to good use."

Suzanne Skoda-Smith, MD, is attending physician at Seattle Childrens Hospital and associate professor in the Department of Pediatrics at the University of Washington School of Medicine. She is clinical director for the Division of Immunology at Seattle Childrens Hospital and associate director of the University of Washington Allergy and Immunology Fellowship Training Program.

She received her undergraduate degree in immunology at University of California at Berkeley, attended University of Miami School of Medicine, completed residency at University of Florida, and received her fellowship training at the University of Alabama at Birmingham. Her focus is on translational therapies for primary immunodeficiency, including hematopoetic cell transplantation, gene therapy and improved supportive care. Dr. Skoda-Smith is a member of the Non-Malignant Transplant Board which is held jointly with members of the Seattle Cancer Care Alliance and Fred Hutchinson Cancer Research Center. As a member of the Center for Immunity and Immunotherapies, as well as the American Society of Gene and Cell Therapy, she participates in clinical trials dedicated to improving treatment for people with primary immune deficiency.

Overview

Board Certification(s)

Pediatrics
Allergy and Immunology

Medical/Professional School

University of Miami - Jackson Memorial Medical Center, Miami

Residency

Pediatrics, University of Florida, Gainsville

Fellowship

Allergy and Immunology, Children's Hospital of Alabama, Birmingham

Clinical Interests

Primary Immunodeficiency Diseases, Hematopoetic Stem Cell Transplantation for Immunodeficiency, Secondary Immunodeficiency associated with Solid Organ Transplantation Clinical care for patients with primary immunodeficiencies

Research Description

My clinical research has been focused on the delivery of care and new therapies to patients with primary immunodeficiency diseases, particularly those needing hematopoetic stem cell transplantation. I am particularly interested in how to bring the promise of new therapies currently in the laboratory setting, to reality in the clinical care arena. I also interface with clinicians skilled in the care of solid organ transplant patients who experience secondary immunodeficiency as a consequence of their transplant therapies.

Research Focus Area

Translational Research, Solid Organ Transplantation, Stem Cell Transplantation

Awards and Honors

Award Name Award Description Awarded By Award Date
SEATTLE MAGAZINE TOP DOCTOR - 2014 Seattle Magazine 2014
K30, Masters Candidate in the Advanced Postgraduate Program in Clinical Investigation University of Florida 2000 - 2001
Dixon Post-Doctorate Fellowship 1995 - 1997
National Research Service Award (NRSA) Training Grant University of Alabama at Birmingham 1994 - 1995
AΩA 1990
Medical School Trustee Scholarship Univeristy of Miami 1986 - 1990

Publications

  • Ortiz MV, Skoda-Smith S, Rauen KA, Allan RW, Slayton WB
    Juvenile myelomonocytic leukemia in a 16-year-old with Noonan syndrome: case report.
    Journal of pediatric hematology/oncology , 2012 Oct. : 34(7)569-72
  • Lundgren IS, Englund JA, Burroughs LM, Torgerson TR, Skoda-Smith S
    Outcomes and duration of Pneumocystis jiroveci pneumonia therapy in infants with severe combined immunodeficiency.
    The Pediatric infectious disease journal , 2012 Jan. : 31(1)95-7
  • Lundgren IS, Englund JA, Burroughs LM, Torgerson TR, Skoda-Smith S
    Outcomes and Duration of Pneumocystis jiroveci Pneumonia Therapy in Infants With Severe Combined Immunodeficiency.
    The Pediatric infectious disease journal , 2011 Aug.
  • Borte M, Bernatowska E, Ochs HD, Roifman CM, Vivaglobin Study Group
    Efficacy and safety of home-based subcutaneous immunoglobulin replacement therapy in paediatric patients with primary immunodeficiencies.
    Clinical and experimental immunology , 2011 June : 164(3)357-64
  • Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders J, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD, Woolfrey AE
    Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
    The Journal of allergy and clinical immunology , 2010 July
  • Suzanne Skoda-Smith, MD
    Postgrafting Immune Suppression Combined with Nonmyeloablative
  • Skoda-Smith S, Torgerson TR, Ochs HD
    Subcutaneous immunoglobulin replacement therapy in the treatment of patients with primary immunodeficiency disease.
    Therapeutics and clinical risk management , 2010 Feb. 2 : 61-10
  • Skoda-Smith S, Torgerson TR, Ochs HD
    Subcutaneous immunoglobulin replacement therapy in the treatment of patients with primary immunodeficiency disease.
    Therapeutics and clinical risk management , 2010 Feb. : 1-10
  • Ochs HD, Gupta S, Kiessling P, Nicolay U, Berger M, Subcutaneous IgG Study Group
    Safety and efficacy of self-administered subcutaneous immunoglobulin in patients with primary immunodeficiency diseases.
    Journal of clinical immunology , 2006 May : 26(3)265-73
  • Suzanne Skoda-Smith, MD
    Using the pneumococcal conjugate vaccine PCV7 (Prevnar) to evaluate the functional antibody response in adults with recurrent sinopulmonary infections.
  • Araya CE, González-Peralta RP, Skoda-Smith S, Dharnidharka VR
    Systemic Epstein-Barr virus infection associated with membranous nephropathy in children.
    Clinical nephrology , 2006 Mar. : 65(3)160-4
  • Suzanne Skoda-Smith, MD
    Systemic Epstein-Barr virus infection-associated membranous nephropathy.
  • Suzanne Skoda-Smith, MD
    A new kindred with X-lined lympho-proliferative disease
  • Ochs HD, Pinciaro PJ, Octagam Study Group
    Octagam 5%, an intravenous IgG product, is efficacious and well tolerated in subjects with primary immunodeficiency diseases.
    Journal of clinical immunology , 2004 May : 24(3)309-14
  • Lejkowski M, Maheshwari A, Calhoun DA, Christensen RD, Skoda-Smith S, Dabrow S
    Persistent perianal abscess in early infancy as a presentation of autoimmune neutropenia.
    Journal of perinatology : official journal of the California Perinatal Association , 2003 July : 23(5)428-30
  • Lejkowski M, Maheshwari A, Calhoun DA, Christensen RD, Skoda-Smith S, Dabrow S
    Persistent perianal abscess in early infancy as a presentation of autoimmune neutropenia.
    Journal of perinatology : official journal of the California Perinatal Association , 2003 July : 428-30
  • Suzanne Skoda-Smith, MD
    Profiling the non-adherent adolescent heart transplant recipient.
  • Ballow M, Berger M, Bonilla FA, Buckley RH, Cunningham-Rundles CH, Fireman P, Kaliner M, Ochs HD, Skoda-Smith S, Sweetser MT, Taki H, Lathia C
    Pharmacokinetics and tolerability of a new intravenous immunoglobulin preparation, IGIV-C, 10% (Gamunex, 10%).
    Vox sanguinis , 2003 Apr, : 202-10
  • Chun HJ, Zheng L, Ahmad M, Wang J, Speirs CK, Siegel RM, Dale JK, Puck J, Davis J, Hall CG, Skoda-Smith S, Atkinson TP, Straus SE, Lenardo MJ
    Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.
    Nature , 2002 Sept. 26 : 419(6905)395-9
  • Chun HJ, Zheng L, Ahmad M, Wang J, Speirs CK, Siegel RM, Dale JK, Puck J, Davis J, Hall CG, Skoda-Smith S, Atkinson TP, Straus SE, Lenardo MJ
    Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.
    Nature , 2002 Sept. : 395-9
  • Aranda JM Jr, Scornik JC, Normann SJ, Lottenberg R, Schofield RS, Pauly DF, Miles M, Hill JA, Sleasman JW, Skoda-Smith S
    Anti-CD20 monoclonal antibody (rituximab) therapy for acute cardiac humoral rejection: a case report.
    Transplantation , 2002 Mar. 27 : 73(6)907-10
  • Aranda JM Jr, Scornik JC, Normann SJ, Lottenberg R, Schofield RS, Pauly DF, Miles M, Hill JA, Sleasman JW, Skoda-Smith S
    Anti-CD20 monoclonal antibody (rituximab) therapy for acute cardiac humoral rejection: a case report.
    Transplantation , 2002 Mar. : 907-10
  • Suzanne Skoda-Smith, MD
    Impact of lymphoproliferative disorders after pediatric liver transplant: a single center ten-year experience.
  • Skoda-Smith S, Douglas VK, Mehta P, Graham-Pole J, Wingard JR
    Treatment of post-transplant lymphoproliferative disease with induction chemotherapy followed by haploidentical peripheral blood stem cell transplantation and Rituximab.
    Bone marrow transplantation , 2001 Feb. : 329-32
  • Suzanne Skoda-Smith, MD
    Pharmacokinetics of a novel IVIG preparation.
  • Suzanne Skoda-Smith, MD
    Distinct T-cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of Zap-70.
  • Elder ME, Skoda-Smith S, Kadlecek TA, Wang F, Wu J, Weiss A
    Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70.
    Journal of immunology (Baltimore, Md. : 1950) , 2001 Jan. : 656-61
  • Suzanne Skoda-Smith, MD
    Donor leukocyte infusions after bone marrow transplantation in children: series from a single institution and review of the literature.
    International Journal of Pediatric Hematology/Oncology 7 , 2001 : 71-79
  • Suzanne Skoda-Smith, MD
    Current management in child neurology
    Vasculitis , 2001
  • Dharnidharka VR, Schowengerdt K, Skoda-Smith S
    Failure of combined costimulatory blockade in animal transplant model.
    Nature medicine , 2000 Feb. : 115
  • Suzanne Skoda-Smith, MD
    Adoptive immunotherapy in children compared to adults.
  • Mehta P, Kedar A, Graham-Pole J, Skoda-Smith S, Wingard JR
    Thalidomide in children undergoing bone marrow transplantation: series at a single institution and review of the literature.
    Pediatrics , 1999 Apr, : e44
  • Skoda-Smith S, Mroczek-Musulman E, Galliani C, Atkinson TP, Watts RG
    Alpha 1-antitrypsin deficiency in a child with X-linked lymphoproliferative disease.
    Archives of pathology & laboratory medicine , 1997 Sept. : 121(9)996-9
  • Skoda-Smith S, Mroczek-Musulman E, Galliani C, Atkinson TP, Watts RG
    Alpha 1-antitrypsin deficiency in a child with X-linked lymphoproliferative disease.
    Archives of pathology & laboratory medicine , 1997 Sept. : 996-9
  • Suzanne Skoda-Smith, MD
    Reversed phosphorylation T-cell receptor subunits following stimulation of lymphocytes from an immunodeficient patient.
  • Sleasman JW, Aleixo LF, Morton A, Skoda-Smith S, Goodenow MM
    CD4+ memory T cells are the predominant population of HIV-1-infected lymphocytes in neonates and children.
    AIDS (London, England) , 1996 Nov. : 1477-84
  • Suzanne Skoda-Smith, MD
    Angioedema following dust mite exposure presenting as suspected food allergy.
  • Suzanne Skoda-Smith, MD
    Rituximab Administration in Second Trimester of Pregnancy for Kidney Transplant Rejection Results in Suppression of Neonatal B-Cell Development
  • Suzanne Skoda-Smith, MD
    Anti-CD20 monoclonal antibody for the treatment of post-transplant lymphoproliferative disease in a pediatric heart transplant recipient.

Presentations

Presentations Title Event Location Date
From 1952 to 2012: The Impact and Evolution of Diagnostics in Allergy and Immunology 6th Annual Alvin D. Wert Lecture in Pediatric Allergy, OHSU Portland, OR Dec. 8, 2011
Identifying Primary Immunodeficiencies: Present and Future Legacy Continuing Medical Education: Current Topics in Pediatrics Conference Portland, OR Nov. 19, 2011
Parent Education Meeting for Persons and Families Living with Primary Immunodeficiency Diseases Immune Deficiency Foundation Seattle, WA Sept. 10, 2011
RASopathies and Other Shard Conditions Hematology/Oncology Friday AM Research Conference Seattle, WA May 13, 2011
Non-Malignant Review Board Presentation Seattle Cancer Care Alliance Seattle, WA Sept. 2009
Severe Combined Immunodeficiency Disease Advance Oncology Day, Seattle Children's Hospital Seattle, WA Feb. 23, 2009
Primary Immunodeficiency for the Hematologist/Oncologist Primary Immunodeficiency for the Hematologist-Oncologist Research Seminar, Seattle Children's Hospital Seattle, WA 2009
Severe Combined Immunodeficiency Disease Advanced Oncology Day, Seattle Children's Hospital Seattle, WA Jan. 1, 2009
Morbid/Mortality discussion on recent SCID patient Fred Hutchinson Cancer Research Center Seattle, WA Nov. 14, 2008
Clinical Approach to Children with Immune Deficiency Disease 15th Annual Care of the Sick Child Conference Orlando, FL Nov. 2007
Antibiotic and Antifungal Therapy in Primary Immune Deficiency Immune Deficiency Foundation 3rd National Conference Orlando, FL June 2005
Peripheral Blood Stem Cell Transplantation for Severe Combined Immunodeficiency Disease Children's Hospital of Cincinnati, Division of Pediatric Hematology and Oncology Cincinnati, OH Jan. 2002
Clues in the Diagnosis of Primary Immunodeficiency American College of Osteopathic Pediatricians Spring Convention Naples, FL June 2001
Emerging Infectious Diseases 29th Annual Florida Pediatric Alumni Association Meeting Amelia Island, GA April 1998
Invited speaker Immune Deficiency Foundation regional conferences 1998 - 2005

Research Funding

Grant Title Grantor Amount Award Date
Lentiviral Gene Therapy of X-linked Agammaglobulinemia NIH/NIAID $ Sept. 23, 2009
Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome NIH/NIAID $ March 1, 2008 - Feb. 28, 2013