Profile

Serge Barcy, PhD

Serge Barcy, PhD

Infectious Disease

Academic Title: Research Assistant Professor

Research Center: Center for Global Infectious Disease Research

Overview

Medical/Professional School

University Libre de Bruxelles, Bruxelles, Belgium
University Libre de Bruxelles, Bruxelles, Belgium

Fellowship

University Libre de Bruxelles, Bruxelles, Belgium
University of Washington, Seattle

Research Description

Dr. Barcy's research focuses on characterizing the effector mechanisms involved in the immune control of chronic viral infection. As an immunologist, he has acquired significant expertise and research experience in immunology, with emphasis on innate and acquired immune control of pathogenic and nonpathogenic infections. His contributions to various preclinical models of infectious diseases (HPV-16/18, HSV-1/2, KSHV/HHV-8) consist mainly in the discovery and preclinical development of therapeutics (antigenic epitopes, immune evasion mechanisms) for the treatment of infectious diseases, immune regulation, and tumor immunotherapy.

Awards and Honors

Award Name Award Description Awarded By Award Date
WaNPRC/ITHS Career Development Award 2010

Publications

  • Gantt S | Gachelet E | Carlsson J | Barcy S | Casper C | Lagunoff M
    Nelfinavir impairs glycosylation of herpes simplex virus 1 envelope proteins and blocks virus maturation.
    PMC4325974 Advances in virology , 2015 - 2015 : 2015687162
  • Staheli JP | Dyen MR | Lewis P | Barcy S
    Discovery and biological characterization of two novel pig-tailed macaque homologs of HHV-6 and HHV-7.
    PMC4312206 Virology , 2014 Dec. - 2014 Dec. : 471-473126-40
  • Gutierrez KD, Morris VA, Wu D, Barcy S, Lagunoff M
    Ets-1 is required for the activation of VEGFR3 during latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells.
    23552426 Journal of virology , 2013 June : 87(12)6758-6768 PMCID: PMC3676105
  • Bruce AG, Bielefeldt-Ohmann H, Barcy S, Bakke AM, Lewis P, Tsai CC, Murnane RD, Rose TM
    Macaque homologs of EBV and KSHV show uniquely different associations with simian AIDS-related lymphomas.
    23055934 PLoS pathogens , 2012 : 8(10)e1002962 PMCID: PMC3464224
  • Barcy S, De Rosa SC, Vieira J, Diem K, Ikoma M, Casper C, Corey L
    Gamma delta+ T cells involvement in viral immune control of chronic human herpesvirus 8 infection.
    18292568 Journal of immunology (Baltimore, Md. : 1950) , 2008 Mar. : 180(5)3417-25
  • Barcy S, Huang ML, Corey L, Koelle DM
    Longitudinal analysis of herpes simplex virus-specific CD4+ cell clonotypes in infected tissues and blood.
    15897986 The Journal of infectious diseases , 2005 June : 191(12)2012-21 PMCID: PMC1382294
  • Koelle DM, Barcy S, Huang ML, Ashley RL, Corey L, Zeh J, Ashton S, Buchwald D
    Markers of viral infection in monozygotic twins discordant for chronic fatigue syndrome.
    12173124 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2002 Sept. : 35(5)518-25
  • Sabath DE, Barcy S, Koelle DM, Zeh J, Ashton S, Buchwald D
    Cellular immunity in monozygotic twins discordant for chronic fatigue syndrome.
    11920301 The Journal of infectious diseases , 2002 Mar. : 185(6)828-32
  • Barcy S and Corey L
    Herpes simplex inhibits the capacity of lymphoblastoid B cell lines to stimulate CD4+ T cells
    11342647 J Immunol , 2001 : 166(10)6242-6249
  • Posavad CM, Huang ML, Barcy S, Koelle DM, and Corey L
    Long term persistence of herpes simplex virus-specific CD8+ CTL in persons with frequently recurring genital herpes
    10878394 J Immunol , 2000 : 165(2)1146-1152
  • Barcy S, Wettendorff M, Leo O, Urbain J, Kruger M, Ceuppens JL, and de Boer M
    FcR cross-linking on monocytes results in impaired T cell stimulatory capacity
    7537534 Int Immunol , 1995 : 7(2)179-189
  • van Gool SW, Barcy S, Devos S, Vandenberghe P, Ceuppens JL, Thielemans K, and de Boer M
    CD80 (B7-1) and CD86 (B7-2): potential targets for immunotherapy?
    8525052 Res Immunol , 1995 : 146(3)183-196
  • Kwekkeboom J, de Rijk D, Kasran A, Barcy S, de Groot C, and de Boer M
    Helper effector function of human T cells stimulated by anti-CD3 mAb can be enhanced by co-stimulatory signals and is partially dependent on CD40-CD40 ligand interaction
    7510232 Eur J Immunol , 1994 : 24(3)508-517
  • DeBoer, Mark and Barcy, Serge
    PATENT: New methods and compounds for the selective modulation of antigen-specific T-cell responsiveness
    WO/1995/032734

Presentations

Presentations Title Event Location Date
Neutralizing antibodies against cell to cell mediated virus transmission Uganda Programs Research-in-Progress meeting Seattle, WA Jan. 24, 2013
KSHV virus spread by cell to cell mediated transmission Herpesviruses Group Meeting Seattle, WA Oct. 9, 2012
Discovery of novel herpesviruses homologues in nonhuman primates Infectious Diseases Research Conference Seattle, WA March 6, 2012
Discovery of novel homologues of HHV6 and HHV7 in pig-tailed macaques STRIDE All Investigators Meeting Seattle, WA Nov. 17, 2011

Research Funding

Grant Title Grantor Amount Award Date
Oral pathogenesis and host interactions of KSHV infection - P01 DE021954 (Rose) NIH/NIDCR $993,231 annual directs June 1, 2011 - April 30, 2016