Rusty Novotny, MD

Rusty Novotny, MD

Neurology, Epilepsy

On staff since July 2009

Children's Title: Director, Epilepsy; Alvord, Gerlich and Rhodes Family Endowed Chair in Pediatric Epilepsy

Academic Title: Professor of Neurology and Pediatrics

Research Center: Center for Integrative Brain Research


  • Esther Enumclaw, Washington 04.20.16

    I was diagnosed with epilepsy when I was about 11. I had never heard of it before and had no idea what it was. When I first had it I didn't know how to cope with it. After working with him for a while, I decided to start medication. He has helped me and my family through my entire journey through epilepsy - all of my different tests, working with my medication, helping through a relapse and now I can say that I've been over a year seizure-free.

  • Jennifer Seattle, WA 07.31.15

    Dr. Novotny is thorough, analytical, intelligent and compassionate. We have a child with complex needs and he thinks through every decision carefully and with thoughtfulness. He is not afraid to answer questions and does so with respect and clear information. We are very impressed with his professionalism and are very thankful we found him!

  • Suzie Kennewick, WA 03.25.13

    I highly recommend Dr. Novotny. He oversaw our son's brain surgery - a focal cortical resection for focal cortical dysplasia which was causing Infantile Spasms. Dr. Novotny is extremely knowledgeable about Infantile Spasms, Adreno-Cortico-Tropic Hormone (ACTH) and its potential benefits and negative side effects. If you live in the Pacific Northwest and Alaska, your best choice for a neurologist is Dr. Novotny. The quality of your child's outcome can depend greatly on having a qualified neurologist who knows what kinds of medical risks to take, when to take them, and when the negative effects of medication are outweighing the risks. I would trust Dr. Novotny with my child's life. He is very thorough, and does not overlook anything. He also does a very complete assessment, and pays attention to the parents' concerns.

  • kim Everett, WA 03.30.11

    Dr. Novotny and his staff have been very easy to approach about any concerns or questions I have about my daughter. He is kind, and knowledgeable, and always takes the time to sit and explain any information to you. I never feel like a question is irrelevant.


Board Certification(s)

Neurology with Special Qualifications in Child Neu

Medical/Professional School

St Louis University School of Medicine Academic Records, St Louis


Pediatrics, UC - Davis School of Medicine, Sacramento
Child Neurology, Stanford University Medical Center, Stanford


Clinical Neurophysiology, Stanford University Medical Center, Stanford
Neurology, Yale University, New Haven

Clinical Interests

clinical neurophysiology and epilepsy surgery in children; neuro-metabolic disorders, developmental neuroimaging; and multimodal neuroimaging in pediatric epilepsy

Research Focus Area

Neuroscience / Neurodevelopment

Awards and Honors

Award Name Award Description Awarded By Award Date
SEATTLE MAGAZINE TOP DOCTOR - 2016 Seattle Magazine 2016
SEATTLE MAGAZINE TOP DOCTOR - 2015 Seattle Magazine 2015
U.S. News Top Doctor U.S. News and World Report 2012
Seattle Magazine Top Doctor - 2012 Seattle Magazine Top Doctor - 2012 Seattle Magazine 2012
 Ad-Hoc reviewer NIH Study section - NIDA NIDA Jan. 1, 2009
S. Weir Mitchell Award Award to Best Manuscript from Junior Investigator American Academy of Neurology 1985


  • Friedman D, Fahlstrom R, EPGP Investigators
    Racial and ethnic differences in epilepsy classification among probands in the Epilepsy Phenome/Genome Project (EPGP).
    24139856 Epilepsy research , 2013 Dec. : 107(3)306-10
  • Addis L, Chiang T, Clarke T, Hardison H, Kugler S, Mandelbaum DE, Novotny E, Wolf S, Strug LJ, Pal DK
    Evidence for linkage of migraine in Rolandic epilepsy to known 1q23 FHM2 and novel 17q22 genetic loci.
    24286483 Genes, brain, and behavior , 2013 Nov. 28
  • Widdess-Walsh P, Dlugos D, Fahlstrom R, Joshi S, Shellhaas R, Boro A, Sullivan J, Geller E, EPGP Investigators
    Lennox-Gastaut syndrome of unknown cause: phenotypic characteristics of patients in the Epilepsy Phenome/Genome Project.
    24116958 Epilepsia , 2013 Nov. : 54(11)1898-904
  • Epi4K Consortium, Epilepsy Phenome/Genome Project, Allen AS, Berkovic SF, Cossette P, Delanty N, Dlugos D, Eichler EE, Epstein MP, Glauser T, Goldstein DB, Han Y, Heinzen EL, Hitomi Y, Howell KB, Johnson MR, Kuzniecky R, Lowenstein DH, Lu YF, Madou MR, Marson AG, Mefford HC, Esmaeeli Nieh S, O'Brien TJ, Ottman R, Petrovski S, Poduri A, Ruzzo EK, Scheffer IE, Sherr EH, Yuskaitis CJ, Abou-Khalil B, Alldredge BK, Bautista JF, Berkovic SF, Boro A, Cascino GD, Consalvo D, Crumrine P, Devinsky O, Dlugos D, Epstein MP, Fiol M, Fountain NB, French J, Friedman D, Geller EB, Glauser T, Glynn S, Haut SR, Hayward J, Helmers SL, Joshi S, Kanner A, Kirsch HE, Knowlton RC, Kossoff EH, Kuperman R, Kuzniecky R, Lowenstein DH, McGuire SM, Motika PV, Novotny EJ, Ottman R, Paolicchi JM, Parent JM, Park K, Poduri A, Scheffer IE, Shellhaas RA, Sherr EH, Shih JJ, Singh R, Sirven J, Smith MC, Sullivan J, Lin Thio L, Venkat A, Vining EP, Von Allmen GK, Weisenberg JL, Widdess-Walsh P, Winawer MR
    De novo mutations in epileptic encephalopathies.
    23934111 Nature , 2013 Sept. 12 : 501(7466)217-21 PMCID: PMC3773011
  • Shain C, Ramgopal S, Fallil Z, Parulkar I, Alongi R, Knowlton R, Poduri A, EPGP Investigators
    Polymicrogyria-associated epilepsy: a multicenter phenotypic study from the Epilepsy Phenome/Genome Project.
    23750890 Epilepsia , 2013 Aug. : 54(8)1368-75 PMCID: PMC3851304
  • EPGP Collaborative, Abou-Khalil B, Alldredge B, Bautista J, Berkovic S, Bluvstein J, Boro A, Cascino G, Consalvo D, Cristofaro S, Crumrine P, Devinsky O, Dlugos D, Epstein M, Fahlstrom R, Fiol M, Fountain N, Fox K, French J, Freyer Karn C, Friedman D, Geller E, Glauser T, Glynn S, Haut S, Hayward J, Helmers S, Joshi S, Kanner A, Kirsch H, Knowlton R, Kossoff E, Kuperman R, Kuzniecky R, Lowenstein D, McGuire S, Motika P, Nesbitt G, Novotny E, Paolicchi J, Parent J, Park K, Poduri A, Risch N, Sadleir L, Scheffer I, Shellhaas R, Sherr E, Shih JJ, Shinnar S, Singh R, Sirven J, Smith M, Sullivan J, Thio LL, Venkat A, Vining E, von Allmen G, Weisenberg J, Widdess-Walsh P, Winawer M
    The epilepsy phenome/genome project.
    23818435 Clinical trials (London, England) , 2013 Aug. : 10(4)568-86
  • Friedman SD, Baker LD, Borson S, Jensen JE, Barsness SM, Craft S, Merriam GR, Otto RK, Novotny EJ, Vitiello MV
    Growth hormone-releasing hormone effects on brain -aminobutyric acid levels in mild cognitive impairment and healthy aging.
    23689947 JAMA neurology , 2013 July : 70(7)883-90 PMCID: PMC3764915
  • Poliachik SL, Poliakov AV, Jansen LA, McDaniel SS, Wray CD, Kuratani J, Saneto RP, Ojemann JG, Novotny EJ Jr
    Tissue localization during resective epilepsy surgery.
    23724842 Neurosurgical focus , 2013 June : 34(6)E8
  • Nesbitt G, McKenna K, Mays V, Carpenter A, Miller K, Williams M, EPGP Investigators
    The Epilepsy Phenome/Genome Project (EPGP) informatics platform.
    22579394 International journal of medical informatics , 2013 Apr, : 82(4)248-59 PMCID: PMC3655424
  • Winawer MR, Connors R, EPGP Investigators
    Evidence for a shared genetic susceptibility to migraine and epilepsy.
    23294289 Epilepsia , 2013 Feb. : 54(2)288-95 PMCID: PMC3566298
  • Weaver KE, Chaovalitwongse WA, Novotny EJ, Poliakov A, Grabowski TG, Ojemann JG
    Local functional connectivity as a pre-surgical tool for seizure focus identification in non-lesion, focal epilepsy.
    23641233 Frontiers in neurology , 2013 : 443 PMCID: PMC3640210
  • Ishak GE, Poliakov AV, Poliachik SL, Saneto RP, Novotny EJ Jr, McDaniel S, Ojemann JG, Shaw DW, Friedman SD
    Tract-based spatial statistical analysis of diffusion tensor imaging in pediatric patients with mitochondrial disease: widespread reduction in fractional anisotropy of white matter tracts.
    22499843 AJNR. American journal of neuroradiology , 2012 Oct. : 33(9)1726-30
  • Ojemann JG, Hersonskey TY, Abeshaus S, Geyer JR, Saneto RP, Novotny EJ, Kollros P, Leary S, Holmes MD
    Epilepsy surgery after treatment of pediatric malignant brain tumors.
    22835666 Seizure : the journal of the British Epilepsy Association , 2012 Oct. : 21(8)624-30
  • Wray CD, Blakely TM, Poliachik SL, Poliakov A, McDaniel SS, Novotny EJ, Miller KJ, Ojemann JG
    Multimodality localization of the sensorimotor cortex in pediatric patients undergoing epilepsy surgery.
    22681317 Journal of neurosurgery. Pediatrics , 2012 July : 10(1)1-6 PMCID: PMC3576481
  • Wray CD, McDaniel SS, Saneto RP, Novotny EJ Jr, Ojemann JG
    Is postresective intraoperative electrocorticography predictive of seizure outcomes in children?
    22546034 Journal of neurosurgery. Pediatrics , 2012 May : 9(5)546-51
  • Khanna PC, Poliakov AV, Ishak GE, Poliachik SL, Friedman SD, Saneto RP, Novotny EJ Jr, Ojemann JG, Shaw DW
    Preserved interhemispheric functional connectivity in a case of corpus callosum agenesis.
    21553342 Neuroradiology , 2012 Feb. : 54(2)177-9
  • Strug LJ, Addis L, Chiang T, Baskurt Z, Li W, Clarke T, Hardison H, Kugler SL, Mandelbaum DE, Novotny EJ, Wolf SM, Pal DK
    The genetics of reading disability in an often excluded sample: novel loci suggested for reading disability in Rolandic epilepsy.
    22815793 PloS one , 2012 : 7(7)e40696 PMCID: PMC3399896
  • Wray CD, Kraemer DL, Yang T, Poliachik SL, Ko AL, Poliakov A, Hebb AO, Novotny EJ, Ojemann JG
    Freehand placement of depth electrodes using electromagnetic frameless stereotactic guidance.
    22044370 Journal of neurosurgery. Pediatrics , 2011 Nov. : 8(5)464-7
  • Negishi M, Martuzzi R, Novotny EJ, Spencer DD, Constable RT
    Functional MRI connectivity as a predictor of the surgical outcome of epilepsy.
    21801165 Epilepsia , 2011 Sept. : 52(9)1733-40 PMCID: PMC3169719
  • Killory BD, Bai X, Negishi M, Vega C, Spann MN, Vestal M, Guo J, Berman R, Danielson N, Trejo G, Shisler D, Novotny EJ Jr, Constable RT, Blumenfeld H
    Impaired attention and network connectivity in childhood absence epilepsy.
    21421063 NeuroImage , 2011 Mar.
  • Berman R, Negishi M, Vestal M, Spann M, Chung MH, Bai X, Purcaro M, Motelow JE, Danielson N, Dix-Cooper L, Enev M, Novotny EJ, Constable RT, Blumenfeld H
    Simultaneous EEG, fMRI, and behavior in typical childhood absence seizures.
    20608963 Epilepsia , 2010 Oct. : 2011-22
  • Bai X, Vestal M, Berman R, Negishi M, Spann M, Vega C, Desalvo M, Novotny EJ, Constable RT, Blumenfeld H
    Dynamic time course of typical childhood absence seizures: EEG, behavior, and functional magnetic resonance imaging.
    20427649 The Journal of neuroscience : the official journal of the Society for Neuroscience , 2010 Apr, 28 : 5884-93
  • Zaveri HP, Pincus SM, Goncharova II, Novotny EJ, Duckrow RB, Spencer DD, Blumenfeld H, Spencer SS
    Background intracranial EEG spectral changes with anti-epileptic drug taper.
    20075002 Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology , 2010 Mar. : 121(3)311-7
  • Zaveri HP, Pincus SM, Goncharova II, Novotny EJ, Duckrow RB, Spencer DD, Blumenfeld H, Spencer SS
    Background intracranial EEG spectral changes with anti-epileptic drug taper.
    20075002 Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology , 2010 Mar. : 311-7
  • Goncharova II, Zaveri HP, Duckrow RB, Novotny EJ, Spencer SS
    Spatial distribution of intracranially recorded spikes in medial and lateral temporal epilepsies.
    19674048 Epilepsia , 2009 Dec. : 2575-85
  • Zaveri HP, Pincus SM, Goncharova II, Novotny EJ, Duckrow RB, Spencer DD, Spencer SS
    A decrease in EEG energy accompanies anti-epileptic drug taper during intracranial monitoring.
    19632096 Epilepsy research , 2009 Oct. : 153-62
  • Strug LJ, Clarke T, Chiang T, Chien M, Baskurt Z, Li W, Dorfman R, Bali B, Wirrell E, Kugler SL, Mandelbaum DE, Wolf SM, McGoldrick P, Hardison H, Novotny EJ, Ju J, Greenberg DA, Russo JJ, Pal DK
    Centrotemporal sharp wave EEG trait in rolandic epilepsy maps to Elongator Protein Complex 4 (ELP4).
    19172991 European journal of human genetics : EJHG , 2009 Sept. : 1171-81
  • Spencer SS, Goncharova II, Duckrow RB, Novotny EJ, Zaveri HP
    Interictal spikes on intracranial recording: behavior, physiology, and implications.
    18479398 Epilepsia , 2008 Nov. : 1881-92
  • Dion MH, Novotny EJ Jr, Carmant L, Cossette P, Nguyen DK
    Lamotrigine therapy of epilepsy with Angelman's syndrome.
    17326790 Epilepsia , 2007 Mar. : 593-6
  • Shetty-Alva N, Novotny EJ, Shetty T, Kuo PH
    Positron emission tomography in Rasmussen's encephalitis.
    17275663 Pediatric neurology , 2007 Feb. : 112-4
  • Pearl PL, Capp PK, Novotny EJ, Gibson KM
    Inherited disorders of neurotransmitters in children and adults.
    16298354 Clinical biochemistry , 2005 Dec. : 1051-8
  • McNally KA, Paige AL, Varghese G, Zhang H, Novotny EJ Jr, Spencer SS, Zubal IG, Blumenfeld H
    Localizing value of ictal-interictal SPECT analyzed by SPM (ISAS).
    16146441 Epilepsia , 2005 Sept. : 1450-64
  • Safriel Y, Pol-Rodriguez M, Novotny EJ, Rothman DL, Fulbright RK
    Reference values for long echo time MR spectroscopy in healthy adults.
    15956513 AJNR. American journal of neuroradiology , 2005 June : 1439-45
  • Trübel H, Herman P, Kampmann C, Huth R, Maciejewski PK, Novotny E, Hyder F
    A novel approach for selective brain cooling: implications for hypercapnia and seizure activity.
    15185071 Intensive care medicine , 2004 Sept. : 1829-33
  • Blumenfeld H, McNally KA, Vanderhill SD, Paige AL, Chung R, Davis K, Norden AD, Stokking R, Studholme C, Novotny EJ Jr, Zubal IG, Spencer SS
    Positive and negative network correlations in temporal lobe epilepsy.
    15084494 Cerebral cortex (New York, N.Y. : 1991) , 2004 Aug. : 892-902
  • Lai JC, White BK, Buerstatte CR, Haddad GG, Novotny EJ Jr, Behar KL
    Chronic hypoxia in development selectively alters the activities of key enzymes of glucose oxidative metabolism in brain regions.
    12718448 Neurochemical research , 2003 June : 933-40
  • Nguyen D, Singh S, Zaatreh M, Novotny E, Levy S, Testa F, Spencer SS
    Hypothalamic hamartomas: seven cases and review of the literature.
    12791326 Epilepsy & behavior : E&B , 2003 June : 246-58
  • Trübel HK, Novotny E, Lister G
    Outcome of coma in children.
    12806258 Current opinion in pediatrics , 2003 June : 283-7
  • Motamedi M, Nguyen DK, Zaatreh M, Singh SP, Westerveld M, Thompson JL, Mattson R, Blumenfeld H, Novotny E, Spencer SS
    Levetiracetam efficacy in refractory partial-onset seizures, especially after failed epilepsy surgery.
    12558576 Epilepsia , 2003 Feb. : 211-4
  • Novotny EJ Jr, Fulbright RK, Pearl PL, Gibson KM, Rothman DL
    Magnetic resonance spectroscopy of neurotransmitters in human brain.
    12891651 Annals of neurology , 2003 : S25-31
  • Pearl PL, Novotny EJ, Acosta MT, Jakobs C, Gibson KM
    Succinic semialdehyde dehydrogenase deficiency in children and adults.
    12891657 Annals of neurology , 2003 : S73-80
  • Zaatreh MM, Spencer DD, Thompson JL, Blumenfeld H, Novotny EJ, Mattson RH, Spencer SS
    Frontal lobe tumoral epilepsy: clinical, neurophysiologic features and predictors of surgical outcome.
    12102675 Epilepsia , 2002 July : 727-33
  • Butchko HH, Stargel WW, Comer CP, Mayhew DA, Benninger C, Blackburn GL, de Sonneville LM, Geha RS, Hertelendy Z, Koestner A, Leon AS, Liepa GU, McMartin KE, Mendenhall CL, Munro IC, Novotny EJ, Renwick AG, Schiffman SS, Schomer DL, Shaywitz BA, Spiers PA, Tephly TR, Thomas JA, Trefz FK
    Aspartame: review of safety.
    12180494 Regulatory toxicology and pharmacology : RTP , 2002 Apr, : S1-93
  • Spencer SS, Katz A, Ebersole J, Novotny E, Mattson R
    Ictal EEG changes with corpus callosum section.
    8504788 Epilepsia , 1993 May : 34(3)568-73

Research Funding

Grant Title Grantor Amount Award Date
Early Onset Epilepsy Consoortium Pediatric Epilepsy Research Foundation June 1, 2013 - May 31, 2014